Condition

Depressive Symptoms clinical trials and research

• 55Clinical trials
• 26NIH research projects
• 18Countries

Newest Depressive Symptoms clinical trials

All recruiting trials (55)

• Morning Activation to Boost Mood After Stroke

  A six-week behavioral program is tested to see if it helps mood and daily functioning in adults who had a stroke and feel depressed or slow to get going in the morning.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07719517

• Sleep More, Stress Less with Neuralli Mood

  This 90-day, open-label study tests whether daily Neuralli Mood capsules can help adults feel less stressed, sleep better, and improve mood and burnout symptoms.

  Recruiting Efforia, Inc · New York, New York · NCT07717385

• Blended Baduanjin and Green Tea Program for Depressive Symptoms in Older Adults

  This study tests whether a 12-week combo of gentle Baduanjin exercise and green tea consumption can help reduce depressive symptoms and improve gut health and quality of life in Hong Kong’s community-dwelling adults aged 65–84.

  Recruiting Hong Kong Baptist University · Kwun Tong · NCT07687940

• Metformin added to antidepressants for depression with obesity in Pakistani adults

  This study tests whether adding metformin to antidepressant therapy helps reduce depressive symptoms and BMI in adults with depression and overweight/obesity in Pakistan.

  Recruiting at 2 sites Riphah International University · Rawalpindi, Punjab Province and 1 other locations · NCT07654179

• rTMS with aerobic exercise for older adults with mild cognitive impairment and depressive symptoms

  This trial tests whether rTMS alone or rTMS plus stationary cycling can improve thinking skills and mood in older adults with MCI and depression.

  Recruiting Cheng-Hsin General Hospital · Taipei, Taipei City · NCT07652775

• Subanesthetic Ketamine for Depressive Symptoms in ICU Patients

  This study tests whether a short course of low-dose ketamine can help reduce depressive symptoms in adults who are in the ICU.

  Recruiting at 2 sites Phase 2 Hospital Italiano de Buenos Aires · Jacksonville, Florida and 1 other locations · NCT07639359

• Baricitinib for Depression and Cognition in Experienced Male Football Players

  In this Phase 2 study, adult male football players with depression and inflammation will try baricitinib to see if reducing inflammation helps their depressive and cognitive symptoms.

  Recruiting at 3 sites Phase 2 Emory University · Atlanta, Georgia and 2 other locations · NCT07608796

• Rise & Thrive: a community-engagement program to help youth manage stress and depressive symptoms

  A group-based program tests whether community engagement activities can help Black and/or Hispanic/Latine youth aged 15-20 see reductions in depressive symptoms.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT07554326

• Mindfulness‑augmented brain stimulation for treatment‑resistant depression

  This trial will test whether combining fast brain stimulation (iTBS) with a digital mindfulness program helps people with treatment‑resistant depression reduce symptoms and improve thinking.

  Recruiting Phase 2 University of California, San Diego · San Diego, California · NCT07512284

• Timed smartphone support to boost social connections for people waiting for outpatient psychotherapy

  This project tests whether a smartphone-based just-in-time support program can reduce daily depressive symptoms and increase received social support for adults waiting for outpatient psychotherapy.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT07471529

• VR-enhanced progressive muscle relaxation for chronic symptoms after burn injury

  This will try progressive muscle relaxation with and without virtual reality to see if it helps adult burn survivors reduce chronic pain, itch, anxiety, sleep problems, or fatigue.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07317271

• Sleep-hygiene education to improve sleep quality and mood in menopausal women.

  This trial will try sleep-hygiene education based on the IMB model to see if it improves sleep quality and reduces depressive symptoms in menopausal women with poor sleep.

  Recruiting Ankara Yildirim Beyazıt University · Ankara · NCT07299903

• Psychological well-being, depression, and quality of life in adults with type 2 diabetes

  This project will see if psychological well-being and depressive symptoms are linked to health-related quality of life in adults with type 2 diabetes attending an outpatient clinic.

  Recruiting National Taiwan University Hospital · Taipei · NCT07241325

• Strength and Pain-Coping Through Resilience and Knowledge for Older Adults

  The SPARK program tests a home-based, nurse-delivered intervention to help adults 50 and older with pain, depressive symptoms, and mobility limits see if their pain and mood improve.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07228520

• Our Voices Matter: racial-justice activism program to reduce depression in Black and Latinx youth

  This program tests whether participating in racial-justice activism can reduce depressive symptoms and stress-related physical risk in Black and Latinx youth ages 15-20.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT07216326

• Developing a gamified app to help 8–12-year-olds with depression manage everyday stressors

  This project will ask children ages 8–12 with increased depressive symptoms and their parents about daily stressors and coping to help design a gamified app that tries to teach emotion regulation.

  Recruiting Ludwig-Maximilians - University of Munich · München, Bavaria · NCT07159347

• Video-feedback program to boost Latine parents' racial-ethnic socialization skills

  This project will try a video-feedback parenting program for Latine parents of 10–14-year-olds to build skills, confidence, and reduce stress when talking about racial-ethnic issues.

  Recruiting Penn State University · Harrisburg, Pennsylvania · NCT07055906

• Music therapy songwriting to improve university students' social connections and mental health

  This project will try songwriting-based music therapy to see if it helps university students aged 18–40 with moderate depression, anxiety, or stress feel better and connect more with others.

  Recruiting The University of Hong Kong · Hong Kong · NCT07024979

• Lifestyle changes to prevent memory problems in older adults with depression

  This trial will test whether a Mediterranean-style diet, regular supervised exercise, or weekly cognitive training can help prevent memory decline and improve mood in people aged 50–80 with depressive symptoms or major depression but no cognitive impairment.

  Recruiting IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia · NCT07009223

• Trauma-Focused Therapy for Refugee Minors with PTSD in Greece

  This study is testing if a special therapy for trauma can help unaccompanied refugee teens in Greece with PTSD feel better compared to the usual treatment they receive.

  Recruiting Panteion University · Athens · NCT06975280

• Engaging Latinx youth with suicidal behavior through a new treatment model

  This study is testing a new treatment model for Latinx youth who have suicidal thoughts or behaviors, to see if adding community health workers can help them and their families feel more supported and engaged.

  Recruiting Bradley Hospital · Providence, Rhode Island · NCT06882798

• Mindfulness app for pre-service teachers' mental health

  This study is testing a mindfulness app to see if it can help future teachers manage anxiety and depression during their last year of training.

  Recruiting University of Alabama, Tuscaloosa · Tuscaloosa, Alabama · NCT06745934

• Predicting depression in patients after heart surgery

  This study is trying to see if a new tool can help predict which patients might develop depression after heart surgery, so they can get help sooner.

  Recruiting University of Zurich · Zurich and 1 other locations · NCT06706323

• Using virtual reality and brain stimulation to help cancer patients with depression

  This study is testing whether using virtual reality and brain stimulation can help cancer patients with depression feel better compared to regular treatments.

  Recruiting at 2 sites University Hospital of Ferrara · Ferrara, FE and 1 other locations · NCT06589544

• Remote tai chi and qigong for older adults with HIV

  This study will test whether twice-weekly, 12-week remote tai chi/qigong classes reduce depressive symptoms in people aged 50–75 living with HIV compared with a matched health education class.

  Recruiting Florida International University · Miami, Florida · NCT06586619

• Mobile app for treating depression in cancer survivors

  This study tests if a mobile app called 'Moodivate' can help cancer survivors who are feeling depressed feel better over 12 weeks.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06582784

• Mindfulness intervention led by social workers for older adults

  This study is testing if a mindfulness program led by social workers can help older adults with mild to moderate depression feel better, especially when they have peer supporters with them.

  Recruiting at 8 sites The University of Hong Kong · Eastern District and 12 other locations · NCT06528132

• MRI-guided low-voltage brain stimulation for depression in Parkinson's disease

  This tests whether MRI-guided low-voltage transcranial direct current stimulation (mgTDCS) can reduce depression and apathy and improve working memory in adults with Parkinson's disease.

  Recruiting University of South Alabama · Mobile, Alabama · NCT06467695

• Understanding the impact of mood disorders and treatment responses

  This study is trying to learn more about how people with depression and bipolar disorder respond to treatment by talking to them weekly for up to 12 weeks to improve future care and predict how well medications might work.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06462196

• Behavioral Activation to prevent and treat depression in older adults

  This study is testing if a short therapy called Behavioral Activation can help older adults in Sweden prevent and treat depression while comparing it to their usual care.

  Recruiting Sormland County Council, Sweden · Eskilstuna, Sörmland · NCT06415838

• Telephone coaching using graphic narratives for dementia caregivers

  This study is testing if telephone coaching with graphic stories can help reduce depression and improve the well-being of caregivers taking care of people with dementia.

  Recruiting The Hong Kong Polytechnic University · Hong Kong SAR · NCT06413849

• Improving sleep to prevent depression and anxiety in at-risk adolescents

  This study is testing if a short therapy for sleep problems can help prevent depression and anxiety in teens aged 12 to 18 who are at risk because of their family history.

  Recruiting University of Calgary · Calgary, Alberta · NCT06358495

• Exploring how dog presence and oxytocin affect trust towards therapists

  This study is testing whether having a dog present during therapy and using an oxytocin nasal spray can help people with depression feel more trust towards their therapists.

  Recruiting Phase 2/3 University of Basel · Basel, Canton of Basel-City · NCT06248710

• Using bright light therapy to help reduce depressive symptoms in adults with intellectual disabilities

  This study tests if bright light therapy can help reduce depression in adults with intellectual disabilities and improve their quality of life.

  Recruiting Erasmus Medical Center · Rotterdam · NCT06215235

• Oh Happy Day Class – Digital Connections for Depression in African Americans

  A mobile app delivers six weekly depression-therapy classes to African American adults to see if it helps reduce depressive symptoms.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06206226

• Preventing depression and suicide in adolescents in special schools

  This study is testing a new program to help prevent depression and suicide in teenagers at special education schools in the Netherlands.

  Recruiting Ggz Oost Brabant · Boekel, Noordoost Brabant · NCT06203899

• Supplementation therapy for anxiety and depression in autistic individuals

  This study is testing if a supplement called PEA can help reduce anxiety and depression in young adults with Level 1 Autism Spectrum Disorder who haven't found relief with other treatments.

  Recruiting University of Udine · Udine, UD · NCT06187090

• Web-based intervention for managing cancer pain in Asian American breast cancer survivors

  This study is testing a new online program to help Asian American breast cancer survivors manage their pain and depression better.

  Recruiting Vanderbilt University · Nashville, Tennessee · NCT06085313

• Expressive writing intervention for sexual minority veterans

  This study tests whether a short writing program can help reduce feelings of depression and anxiety in sexual minority veterans by allowing them to express their thoughts and emotions about their experiences.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT05897021

• Auricular acupuncture for treating depression during the Covid-19 pandemic

  This study is testing if auricular acupuncture can help university students with moderate depression feel better during the Covid-19 pandemic.

  Recruiting Universidade do Sul de Santa Catarina · Palhoça, Santa Catarina · NCT05855421

• A program to support mental health in American Indian and Alaska Native communities

  This study is testing a new program designed to help pregnant women and caregivers in American Indian and Alaska Native communities improve their mental health and coping skills.

  Recruiting at 3 sites Johns Hopkins Bloomberg School of Public Health · Chinle, Arizona and 2 other locations · NCT05836090

• Parent training intervention for preventing childhood mental health problems

  This study is testing a new parent training program to see if it can help prevent mental health problems in children aged 4 to 12 years compared to regular care.

  Recruiting Norwegian Center for Child Behavioral Development · Oslo · NCT05800522

• MAYA mobile CBT for middle-aged and older adults with anxiety or depression

  This trial will test whether the MAYA iPhone app helps people age 40 and older with anxiety or depression learn CBT coping skills through brief, twice-weekly sessions.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT05754151

• Support program for women recovering from ovarian cancer

  This study is testing a new online support program for women who have finished treatment for ovarian cancer to see if it improves their quality of life compared to standard care.

  Recruiting at 2 sites Baylor College of Medicine · Dallas, Texas and 2 other locations · NCT05752448

• Parent-led treatment for children with trauma symptoms

  This study is testing a new parent-led treatment for children aged 7-12 with trauma symptoms to see if it helps them feel better compared to regular care.

  Recruiting at 2 sites Norwegian Center for Violence and Traumatic Stress Studies · Asker and 1 other locations · NCT05734547

• Exploring profiles in adults with binge eating disorder

  This study is trying to see if different emotional and thinking patterns in adults with binge eating disorder can help predict how well they respond to treatment over time.

  Recruiting at 2 sites Aarhus University Hospital · Aarhus, Central Jutland and 2 other locations · NCT05726721

• Using RxWell to Reduce Opioid Use After Knee or Hip Surgery

  This study is testing whether a digital tool called RxWell can help people with mood disorders who are having knee or hip surgery reduce their opioid use and improve their mental health after the operation.

  Recruiting at 3 sites University of Pittsburgh · Monroeville, Pennsylvania and 2 other locations · NCT05658796

• Using machine learning to improve digital mental health interventions

  This study is testing if using machine learning can help find the best digital mental health program for people with anxiety and depression to improve their care and results.

  Recruiting Boston University Charles River Campus · Boston, Massachusetts · NCT05567640

• Mind-Body Skills Group for Graduate Students

  This study is testing an 8-week program that teaches medical graduate students relaxation and mindfulness techniques to see if it helps improve their mental health and reduce anxiety and depression.

  Recruiting Weill Medical College of Cornell University · White Plains, New York · NCT05447689

• Using rTMS to treat depression in military personnel with mild TBI

  This study is testing two different types of brain stimulation to see if they can help military personnel and veterans with mild brain injuries feel less depressed.

  Recruiting at 3 sites Henry M. Jackson Foundation for the Advancement of Military Medicine · Palo Alto, California and 2 other locations · NCT05426967

• A tool for managing stress and improving quality of life in cancer patients

  This study is testing an online program called My Wellbeing Guide to see if it can help cancer patients feel less depressed and improve their quality of life.

  Recruiting Northwestern University · Chicago, Illinois · NCT05369429

• A study on caregiver stress and sleep patterns in dementia caregivers

  This study is testing a new program to help family caregivers of dementia patients feel better and sleep more soundly by improving their morning energy and reducing feelings of sadness.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05219955

• Using psilocybin to treat depression in people with mild cognitive impairment or early Alzheimer's disease

  This study is testing if psilocybin can help improve mood and quality of life for people with mild cognitive impairment or early Alzheimer's disease who are feeling depressed.

  Recruiting Early Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT04123314

• EMDR combined with gentle brain stimulation (tDCS) for fibromyalgia

  This project will test whether adding non-invasive brain stimulation (tDCS) to EMDR helps people with fibromyalgia who also have trauma-related symptoms, depression, or anxiety.

  Recruiting Parc de Salut Mar · Barcelona, Catalonia · NCT04084795

• Understanding health trends in Puerto Rico

  This study is trying to understand health trends in Puerto Rico by looking at diet, mental health, and heart health in adults aged 30-75 over time.

  Recruiting Harvard School of Public Health (HSPH) · San Juan · NCT03794531

NIH-funded research (26)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms

  A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11609950

• Real-time brain training to reduce depressive symptoms with feedback from fMRI

  A study tests a new real-time brain feedback therapy that uses cloud-based pattern reading from MRI to help adults with depression reduce negative attention biases.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11406020

• Cultural variation in how spousal depressive symptoms relate to Alzheimer's and physical health

  A study looking at how a spouse’s depression levels might influence Alzheimer's progression and overall health across diverse cultural groups.

  NIH research Michigan State University · East Lansing, United States · NIH-11332792

• How short-term cannabis use and withdrawal affect teen mood and suicidal thoughts

  Teens who use cannabis daily and have recent depression or suicidal thoughts will use a smartphone app that records their mood and cannabis use to link moments of use or withdrawal with increases in sadness or suicidal thinking.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11323622

• Depression and brain changes linked to memory decline in mild cognitive impairment

  This project looks at whether depression in people with mild cognitive impairment is tied to tau protein build-up, lower brain blood flow, and faster memory decline.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11317190

• How depression and aging together affect memory and thinking

  This work looks at whether depression and getting older combine to harm memory and thinking in adults from Black, Mexican American, and non-Hispanic White backgrounds.

  NIH research University of Texas at Austin · Austin, United States · NIH-11303413

• A mind-body program to help knee OA with obesity and depression

  A multi-site study is testing GetHealthy-OA, a mind-body program designed for people who have knee osteoarthritis along with obesity and depressive symptoms.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11290455

• Investigating how racial discrimination and vitamin D levels affect preterm birth in Black women

  This study is looking at how experiences of racial discrimination, feelings of depression, and low vitamin D levels might affect the risk of preterm birth in Black women, by examining blood samples to find out how these factors work together during pregnancy.

  NIH research University of Texas Arlington · Arlington, United States · NIH-11228745

• iManageAYA: a smartphone program to help young cancer survivors with depressive symptoms

  This project will create and refine a mobile app to help adolescent and young adult cancer survivors manage depressive symptoms on-demand.

  NIH research East Carolina University · Greenville, United States · NIH-11171724

• How maternal depression affects infant self-regulation

  This study looks at how feelings of depression in mothers during and after pregnancy can affect their babies' ability to manage their emotions and behaviors, helping us understand how to support both moms and their little ones better.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11162159

• A digital mindfulness program to help cancer survivors with depression

  This study is testing a daily mindfulness program delivered through text messages to help cancer survivors who have finished treatment feel less depressed, making it easy for them to fit into their everyday lives.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11136759

• How spousal depression affects Alzheimer's disease and health across cultures

  This study looks at how a spouse's feelings of depression can affect the health and thinking abilities of people with Alzheimer's disease, and it aims to help us understand these effects better across different cultures.

  NIH research Michigan State University · East Lansing, United States · NIH-11129427

• Understanding how social experiences affect mental health in adolescent girls

  This study looks at how daily social interactions, both online and in person, affect the mental health of girls aged 13-17, especially those who are at higher risk for issues like depression and self-harm, to help find ways to support them better.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11124028

• Understanding how cannabis use affects depression and suicidal thoughts in adolescents

  This study is looking at how using cannabis might affect feelings of sadness and thoughts about suicide in teens aged 12 to 18, by checking in with them through their smartphones over two weeks to see how their mood changes with their cannabis use.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11123455

• How age and depression affect memory in diverse adults

  This study is looking at how age and depression affect memory problems in adults from different racial backgrounds, aiming to help us understand how these issues might lead to cognitive decline and Alzheimer's disease.

  NIH research University of Texas at Austin · Austin, United States · NIH-11098712

• Understanding how inflammation and mitochondrial issues affect depression in people with acute HIV infection

  This study is looking at how inflammation and problems with energy production in cells might be linked to feelings of depression in people who have just been diagnosed with HIV, especially for those who also use certain stimulants, to help find better ways to support their mental health during treatment.

  NIH research Florida International University · Miami, United States · NIH-11085515

• Exploring how childhood hardships affect adult depression in rural Uganda

  This study looks at how tough experiences in childhood, like abuse or neglect, affect depression in adults living in rural Uganda, and it aims to find better ways to help people with their mental health based on what they went through when they were younger.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11071548

• Exploring how depression affects brain health and cognitive decline in older adults with mild cognitive impairment.

  This study is looking at how depression might affect brain health in older adults with mild cognitive impairment, helping us understand if and how it could speed up memory problems and possibly lead to dementia.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11054506

• How social media affects depression and body image in teenagers

  This study is looking at how using social media affects teenagers, especially how comparing themselves to others online might make them feel sad or unhappy about their bodies, and it involves tracking their social media use and feelings through a special app.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11045859

• Real-time brain feedback to break stuck negative attention in depression

  This approach gives people with major depression real-time brain-guided feedback to help reduce persistent negative attention and mood symptoms.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10950399

• Developing a mobile app to help young cancer survivors manage depression

  This study is testing a new mobile app that helps young people who have survived cancer manage feelings of sadness, making it easier for them to find support and resources whenever they need it.

  NIH research East Carolina University · Greenville, United States · NIH-10930145

• Understanding how depression affects young people with autism

  This study is looking at how the brains of teenagers with autism and depression work differently, so we can find better ways to help them feel better.

  NIH research Emma Pendleton Bradley Hospital · Riverside, UNITED STATES · NIH-10893042

• A program using social media to help mothers with postpartum depression improve parenting skills

  This study is looking at a social media program that helps new moms dealing with postpartum depression improve their parenting skills and support their baby's growth, while also offering online treatment for their depression to see if it makes a positive difference for both moms and their little ones.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10877888

• An internet program to help prevent and reduce depression in pregnant and postpartum women

  This study is testing a friendly online program called 'Mamma Mia' that helps pregnant and new moms manage feelings of sadness, making it easier for them to feel supported and in control during this special time.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10810691

• Investigating biomarkers of depression after acute illness

  This study is looking at how people might feel depressed after having a stroke, and it wants to find out if certain chemicals in the body can help predict who might experience these feelings, so we can create better ways to help them feel better.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10558617

• The impact of migraine and depression on new mothers' quality of life.

  This study looks at how migraines and feelings of depression can impact the lives of new moms, especially those who might be facing extra challenges, and it aims to find ways to help them feel better and enjoy their time with their babies.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10488056

Related topics

Quick answers

How many Depressive Symptoms clinical trials are recruiting right now?

55, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (28 trials), Hong Kong (5 trials), Italy (3 trials), Switzerland (3 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Early Phase 1: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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