Understanding the impact of mood disorders and treatment responses

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to gather systematic data on individuals receiving treatment for mood disorders, specifically depression and bipolar disorder, to better understand their experiences and responses to treatment. Participants, aged 18 and older, will undergo weekly interviews and questionnaires over a period of up to 12 weeks, with the possibility of extension based on treatment needs. The study focuses on identifying predictors of treatment response and biomarkers associated with antidepressant efficacy, utilizing clinical ratings and neurobiological assessments. The ultimate goal is to enhance treatment strategies and predict medication effectiveness for individuals at risk of suicide.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

* Signed consent for Protocol 01-M-0254: The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers
* Age 18 years or older
* Able to provide informed consent
* Able to read and write English

EXCLUSION CRITERIA:

* Unstable medical conditions in the opinion of the investigator that would preclude participation in outpatient or inpatient treatment.
* Pregnancy
* Participation in the Protocol 01-M-0254: The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers, as a healthy volunteer.
* Participants with a history of DSM-IV substance or alcohol abuse or dependence, or DSM-5 substance use disorder (except for caffeine, nicotine, or cannabis), or moderate to severe alcohol use disorder, within the preceding three months. In addition, participants who are currently using drugs (except for caffeine, nicotine, or cannabis) must not have used illicit substances or known drugs of abuse in the two weeks prior to consent and must have a negative drug urine test (except for prescribed benzodiazepines or stimulants) prior to enrolling in the study. Cannabis use is exclusionary if the use is daily, or if participants are unable to abstain during the study, or if function of daily life is impaired by use as determined by a clinician.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Elizabeth D Ballard, Ph.D. — National Institute of Mental Health (NIMH)
• Study coordinator: Kelly T Hurst, Ph.D.
• Email: moodresearch@mail.nih.gov
• Phone: (877) 646-3644

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Testing a new drug for treatment-resistant depression

  This study is testing a new drug called HNK to see if it can help people with treatment-resistant depression feel better when other medications haven't worked.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06511908

• Nebulized ketamine treatment for major depression in hospitalized patients

  This study is testing if breathing in ketamine can help people with moderate to severe depression feel better while they are in the hospital.

  Recruiting Phase 3 Maimonides Medical Center · Brooklyn, New York · NCT06752759

• Effects of Dexmedetomidine on cognitive recovery after cardiac surgery

  This study is testing if a medication called Dexmedetomidine can help people recover their thinking skills better after having heart surgery.

  Recruiting at 3 sites Phase 4 Sunnybrook Health Sciences Centre · Vancouver, British Columbia and 7 other locations · NCT04289142

• Mindfulness‑augmented brain stimulation for treatment‑resistant depression

  This trial will test whether combining fast brain stimulation (iTBS) with a digital mindfulness program helps people with treatment‑resistant depression reduce symptoms and improve thinking.

  Recruiting Phase 2 University of California, San Diego · San Diego, California · NCT07512284

• Combining the Youth-Nominated Support Team with CBT for Black adolescents at acute suicide risk

  This project will test whether adding a computer-assisted Youth-Nominated Support Team to Cognitive Behavioral Therapy for Suicide Prevention helps Black adolescents (ages 12-17) who come to an urban emergency setting with suicidal thoughts or self-injury.

  Recruiting at 2 sites University of Michigan · Detroit, Michigan and 1 other locations · NCT07506460

• Longitudinal look at how lasting TMS benefits can be predicted for depression

  This study follows people with major depressive disorder who responded to prior rTMS to see what factors predict how long their response lasts.

  Recruiting Hospital Center Guillaume Régnier · Rennes · NCT07684911

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.