MRI-guided low-voltage brain stimulation for depression in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional protocol compares active fMRI-model guided transcranial direct current stimulation (mgTDCS) to a sham (zero-amp) control in adults with Parkinson's disease who have elevated depressive symptoms. Participants complete baseline and post-intervention EEG recordings, self-report mood and apathy measures, and neuropsychological tests of working memory. Treatment is delivered with BIOPAC Stimsola devices across 15 sessions over 4–5 weeks, each session consisting of two 13-minute stimulations separated by 20 minutes of rest. An age-matched non-Parkinson's depressed control group is included to determine whether effects are specific to Parkinson's or generalize to depression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 19 to 65 years in age.
* Parkinson's Group must have a physician dx of Parkinson's Disease
* Must meet exhibit elevated levels of depression on the Beck Depression Inventory (scores of 20 or above).
* Must be willing and able to travel of the Psychology Department for EEG and tDCS sessions.
* Participants who have undergone surgery for Deep Brain Stimulation implantation may be enrolled if advised to and monitored by their physician.
* Read and understand spoken English.

Exclusion Criteria:

* No history of or being treated for epilepsy or other seizure disorders.
* No history of penetrating head wounds or TBI greater than mild TBI.
* No history of atypical Parkinson's

Where it's running

• University of South Alabama
  Mobile, Alabama, United States Recruiting

Study contacts

• Principal investigator: John Shelley-Tremblay, PhD — 2514606883
• Study coordinator: John F Shelley-Tremblay, PhD
• Email: jstremblay@southalabama.edu
• Phone: 2514606883

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.