Understanding how inflammation and mitochondrial issues affect depression in people with acute HIV infection
Official title: Probing the Proteome: Depressive Symptoms, Inflammation and Mitochondrial Perturbations in Acute HIV Infection
Funded at Florida International University · NIH-11085515 · Data updated 2026-11-12
This study is looking at how inflammation and problems with energy production in cells might be linked to feelings of depression in people who have just been diagnosed with HIV, especially for those who also use certain stimulants, to help find better ways to support their mental health during treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $45,516 |
| NIH project number | 1R36MH139364-01 |
| Project ID | NIH-11085515 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute HIV infection, particularly those who may also use amphetamine-type stimulants.
✕Less likely to help
Patients who are not experiencing acute HIV infection or do not have depressive symptoms may not benefit from this research.
What this research studies
This research investigates the relationship between inflammation, mitochondrial dysfunction, and depressive symptoms in individuals experiencing acute HIV infection. It aims to identify molecular mechanisms that could predict long-term depressive symptoms during antiretroviral therapy, particularly considering the effects of amphetamine-type stimulant use. By analyzing biological markers and their impact on emotional health, the study seeks to provide insights that could improve treatment strategies for those affected by both HIV and depression.
Why it matters
Potential benefit: If successful, this research could lead to better management of depressive symptoms in patients with acute HIV infection, improving their overall quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the links between inflammation, mitochondrial dysfunction, and mental health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Chavez, Jennifer Vanessa — Florida International University
- Study coordinator: Chavez, Jennifer Vanessa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.