Condition

Heart Diseases clinical trials and research

• 55Clinical trials
• 5NIH research projects
• 45Countries

Newest Heart Diseases clinical trials

All recruiting trials (55)

• TRIFORMIS RESILIA heart valve real-world results in tricuspid disease

  A real-world, observational study to see how the Edwards TRIFORMIS RESILIA tricuspid heart valve performs in adults needing tricuspid valve replacement.

  Recruiting Edwards Lifesciences · Carmel, Indiana · NCT07684313

• Women-Focused Education in Cardiac Rehab

  This pilot test checks if a women-focused education program added to standard cardiac rehab is feasible and helps women improve heart-health knowledge, quality of life, and healthy behaviors.

  Recruiting University Health Network, Toronto · Barrie, Ontario and 2 other locations · NCT07550036

• Transitioning people with recurrent pericarditis to KPL-387 monotherapy dosing and administration

  This trial will try switching people with well-controlled recurrent pericarditis from their current therapies to KPL-387 alone for up to 16 weeks to see if symptoms and inflammation stay controlled and the drug is tolerable.

  Recruiting at 48 sites Phase 2 Kiniksa Pharmaceuticals International, plc · Phoenix, Arizona and 47 other locations · NCT07288216

• Coronary CT angiography–guided calcium modification during PCI for calcified coronary artery disease

  This study will see if using CT angiography to plan calcium treatment before stenting helps people with flow-limiting, calcified coronary artery disease have better stent results and faster procedures compared with the usual ultrasound-guided PCI while keeping similar safety.

  Recruiting at 10 sites Fundación EPIC · Boston, Massachusetts and 14 other locations · NCT07286578

• Freesolve resorbable magnesium scaffold vs. Xience stent for up to two new heart artery lesions

  This trial tests whether the Freesolve resorbable magnesium scaffold works as well as the Xience drug-eluting stent for treating up to two new coronary artery lesions in adults.

  Recruiting at 3 sites Teleflex · Washington D.C., District of Columbia and 2 other locations · NCT07258290

• Wearable cardiac monitoring for early arrhythmia detection and remote management

  This project will try a smartwatch-based system to spot arrhythmias early and help manage adults with chronic or recently treated heart problems.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07174206

• Angiography versus electrogram guidance for Bachmann bundle pacemaker lead placement

  This study will try two ways to guide placement of an atrial pacemaker wire in the Bachmann bundle for people getting a permanent pacemaker or ICD to see which method leads to more successful placement.

  Recruiting Geisinger Clinic · Wilkes-Barre, Pennsylvania · NCT07110922

• Whole milk versus skim milk effects on cholesterol and blood sugar

  This trial will test whether drinking whole milk or skim milk for two months at a time changes cholesterol and insulin resistance in adults who regularly drink milk.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07087184

• Heart assessment to check repeat-stroke risk in people with atrial fibrillation

  This project will test whether detailed heart examinations can find which people with atrial fibrillation who just had an ischemic stroke are at high risk of having another stroke.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06954610

• Predicting depression in patients after heart surgery

  This study is trying to see if a new tool can help predict which patients might develop depression after heart surgery, so they can get help sooner.

  Recruiting University of Zurich · Zurich and 1 other locations · NCT06706323

• Comparing heart imaging techniques for coronary artery disease

  This study is testing if a new heart imaging method can better identify problems in patients suspected of having coronary artery disease compared to a traditional imaging technique.

  Recruiting Semmelweis University · Budapest, Budapest · NCT06670768

• Rigid plate versus wire closure of the breastbone after open-heart surgery for high-risk adults

  This trial tests whether using a rigid sternal plate instead of traditional wire closure lowers wound complications and pain after open-heart surgery in adults at higher risk for sternal problems.

  Recruiting University Hospitals Cleveland Medical Center · Cleveland, Ohio · NCT06660186

• Natural history of PKP2-related arrhythmogenic cardiomyopathy

  This project will collect past and ongoing health information to see how PKP2-related arrhythmogenic cardiomyopathy progresses in people managed with standard care.

  Recruiting at 2 sites Rocket Pharmaceuticals Inc. · Boston, Massachusetts and 2 other locations · NCT06644742

• Short-term high-dose rosuvastatin effects on coronary plaque using photon-counting CT

  This trial tests whether a short course of intensified rosuvastatin (40 mg) changes coronary plaque composition and flow on photon‑counting coronary CT in statin‑naive adults with stable chest pain and mild atherosclerosis.

  Recruiting Semmelweis University · Budapest, Budapest · NCT06603363

• Registry for Abbott's heart devices

  This study is collecting information to see how safe and effective Abbott's heart devices are for patients getting them implanted in real-life hospital settings.

  Recruiting at 27 sites Abbott Medical Devices · Los Angeles, California and 35 other locations · NCT06590467

• Improving digital participation among Black and non-White Hispanic adults with heart and metabolic conditions

  This project will test whether decentralized, smartphone-based methods plus extra digital or social support help Black and non-White Hispanic adults with heart and cardiometabolic conditions stay enrolled and complete clinical research activities.

  Recruiting University of Miami · Miami, Florida · NCT06587204

• Preventing transthyretin amyloidosis in young carriers of a genetic variant

  This study is testing if a medication called acoramidis can help prevent transthyretin amyloidosis in young adults who carry a specific genetic variant that puts them at risk for the disease.

  Recruiting at 104 sites Phase 3 Eidos Therapeutics, a BridgeBio company · La Jolla, California and 103 other locations · NCT06563895

• Single versus dual antiplatelet therapy after drug-coated balloon angioplasty in elderly or high-bleeding-risk patients

  This study tests whether taking one antiplatelet medicine is as safe and causes less bleeding than taking two medicines for people aged 75 or older, or adults at high bleeding risk, after drug-coated balloon angioplasty for coronary artery disease.

  Recruiting Fondazione Ricerca e Innovazione Cardiovascolare ETS · Milan, MI · NCT06535568

• Evaluating a heart pump for patients with advanced heart failure

  This study is testing if a heart pump can help people with advanced heart failure feel better compared to standard medication, while also checking if certain pressure readings can help find the right patients for this treatment.

  Recruiting at 68 sites Abbott Medical Devices · Phoenix, Arizona and 69 other locations · NCT06526195

• Using fibrinolysis inhibitors after heart surgery to reduce blood transfusions

  This study is testing if using a medication to prevent blood clots during and after heart surgery can help reduce the need for blood transfusions in patients.

  Recruiting Saint Petersburg State University, Russia · Saint Petersburg and 1 other locations · NCT06493227

• Comparing inspiratory muscle training and Baduanjin exercises for heart health

  This study tests whether breathing exercises or a special exercise program can help people with hypertrophic cardiomyopathy improve their lung function, exercise ability, and overall quality of life.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT06490250

• Comparing CT and DSA for selecting LAA occluder sizes in heart procedures

  This study is testing whether using CT or DSA imaging helps doctors choose the right size of heart device for patients with atrial fibrillation who need a specific procedure.

  Recruiting First Affiliated Hospital of Shantou University Medical College · Foshan, Guangdong and 4 other locations · NCT06455644

• Using echocardiography to improve heart care in nursing homes

  This study tests if using echocardiograms in nursing homes can help improve heart care and reduce hospital visits for residents with heart disease.

  Recruiting Nantes University Hospital · Nantes, Loire-Atlantique · NCT06445231

• Continuous diluted Lumason infusion versus undiluted Lumason bolus for clearer left‑ventricle ultrasound images

  This will test whether a continuous, diluted Lumason infusion gives clearer left‑ventricle ultrasound images than the standard undiluted Lumason bolus in adults whose left ventricle is hard to visualize.

  Recruiting at 4 sites Phase 3 Bracco Diagnostics, Inc · West Hills, California and 5 other locations · NCT06400004

• Culturally tailored smartphone program to boost physical activity in African American women

  This study tests a smartphone program called Smart Walk to see if it can help African American women be more active and lower their risk of heart disease and diabetes.

  Recruiting Phase 2 Arizona State University · Phoenix, Arizona · NCT06337708

• Using a smartphone device to record 12-lead ECGs for heart attack diagnosis

  This study is testing a smartphone device that records heart activity to see if it can help doctors quickly diagnose heart attacks in adults who come to the emergency room with chest pain.

  Recruiting at 2 sites AliveCor · Rochester, Minnesota and 3 other locations · NCT06271577

• Evaluating a non-invasive method for cardiac resynchronization therapy

  This study tests a new non-invasive device to see how well cardiac resynchronization therapy works for people with heart failure and left bundle branch block during their treatment.

  Recruiting Oslo University Hospital · Oslo · NCT05868616

• Assessing heart disease and diabetes risk in women during and after pregnancy

  This study is trying to see how pregnancy complications like pre-eclampsia affect women's chances of developing heart disease and diabetes later on, by following women who are trying to get pregnant and comparing them to those who aren't.

  Recruiting at 3 sites Cambridge University Hospitals NHS Foundation Trust · Cambridge and 6 other locations · NCT05856318

• Optimizing beta-blocker use in older adults with heart failure

  This study is trying to see if a personalized approach to adjusting beta-blocker medication can help older adults with heart failure feel more confident in their treatment and manage their condition better.

  Recruiting Phase 4 Weill Medical College of Cornell University · New York, New York · NCT05585125

• Collection of blood samples to study pediatric heart disease

  This study is collecting blood samples from kids with congenital heart disease to see if they can create special cells that help researchers understand and treat heart problems in children better.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT05550324

• Digital healthcare application for cardiac patients

  This study tests a digital health app called VIRTUES to see if it can help people with heart conditions manage their health better, especially those living in rural areas without easy access to clinics.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT05452356

• Registry of South Asians with Coronary Plaque Assessment

  This study is trying to understand why South Asians are at a higher risk for heart disease by looking at their coronary plaque and collecting health information from them and others.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05367297

• Catheter ablation for consecutive atrial tachycardia after AF or heart surgery

  This trial will test whether a focused, minimal-area catheter ablation guided by ultra-high-density mapping or a standard broader ablation better prevents recurrent atrial tachycardia in people who develop AT after prior atrial fibrillation ablation or cardiac surgery.

  Recruiting at 6 sites Evangelical Hospital Düsseldorf · Hamburg, Free and Hanseatic City of Hamburg and 5 other locations · NCT05239364

• Monitoring the safety and performance of Occlutech medical devices for heart procedures

  This study is testing how safe and effective Occlutech medical devices are for heart procedures by collecting feedback from doctors using them in everyday practice.

  Recruiting at 28 sites Occlutech International AB · Erlangen and 35 other locations · NCT05174442

• Follow-up of patients treated with TricValve® for heart valve issues

  This study follows patients who have had treatment for severe tricuspid regurgitation using the TricValve® system to see how well the valve is working over the next five years.

  Recruiting at 12 sites P+F Products + Features GmbH · Sankt Pölten, Lower Austria and 27 other locations · NCT05114850

• Evaluating the effectiveness and safety of Synergy XD and Megatron stents

  This study is testing how well and safely the Synergy XD and Megatron stents work for people with coronary artery disease compared to other stents in real-life situations.

  Recruiting at 19 sites Asan Medical Center · Anyang and 22 other locations · NCT05044273

• Investigating heart disease risk factors in psoriasis patients

  This study is trying to see if certain heart-related markers can help predict heart disease risk in people with psoriasis.

  Recruiting Herlev and Gentofte Hospital · Hellerup, Copenhagne · NCT04950218

• Registry to evaluate the safety of a new venous cannula for patients with heart failure

  This study is testing the safety of a new venous cannula for patients with heart failure who are using a special heart pump to see how well it works and if it has any risks.

  Recruiting Berlin Heart GmbH · Munich · NCT04782232

• Personalized dietary responses for better health

  This study is testing how different foods affect people's health based on their unique responses, and it's for individuals taking part in the ZOE testing program.

  Recruiting at 2 sites Zoe Global Limited · Needham, Massachusetts and 1 other locations · NCT04735835

• Collection and storage of human biological samples for research

  This study is about collecting and storing biological samples from people with different health conditions to help researchers find better ways to prevent, diagnose, and treat diseases.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT04706481

• Evaluating a new type of vascular graft for heart surgery in children

  This study is testing a new type of heart surgery graft for children to see if it is safe and works well for their needs.

  Recruiting Phase 2 Nationwide Children's Hospital · Columbus, Ohio · NCT04467671

• Registry for patients referred to cardio-oncology

  This study is collecting information from cancer patients who are referred for heart health checks to see how cancer treatments might affect their hearts.

  Recruiting European Georges Pompidou Hospital · Paris · NCT04407780

• Identifying Risk Factors for Heart Toxicity from Immune Checkpoint Inhibitors

  This study is trying to find out what factors might increase the risk of heart problems in people receiving immune checkpoint inhibitors for cancer treatment.

  Recruiting Groupe Hospitalier Pitie-Salpetriere · Paris · NCT04294771

• Study on chronic kidney disease in American Indian populations

  This study looks at chronic kidney disease and heart problems in American Indians to see what makes their health different and to gather important health information for future research.

  Recruiting at 2 sites University of New Mexico · Phoenix, Arizona and 2 other locations · NCT04185844

• Comparing single and multiple arterial grafts in women with heart disease

  This study is testing whether using one or more artery grafts during heart surgery can lead to better health outcomes and quality of life for women with heart disease.

  Recruiting at 116 sites Weill Medical College of Cornell University · Los Angeles, California and 145 other locations · NCT04124120

• Comparing non-invasive blood pressure monitoring with invasive methods after cardiac surgery

  This study is testing a new non-invasive blood pressure monitor to see if it gives accurate readings compared to traditional invasive methods right after heart surgery.

  Recruiting Biobeat Technologies Ltd. · Ramat Gan · NCT04071015

• Understanding health trends in Puerto Rico

  This study is trying to understand health trends in Puerto Rico by looking at diet, mental health, and heart health in adults aged 30-75 over time.

  Recruiting Harvard School of Public Health (HSPH) · San Juan · NCT03794531

• A digital platform for understanding genetic risks of heart diseases

  This study tests whether giving people information about their genetic risk for heart disease can help them make better health choices and improve their lifestyles.

  Recruiting Scripps Translational Science Institute · La Jolla, California · NCT03277365

• Single versus multiple arterial grafts for coronary bypass

  This trial will test whether using two or more arterial grafts instead of a single arterial graft during planned coronary artery bypass surgery for people with coronary artery disease leads to fewer deaths, strokes, heart attacks, or repeat procedures.

  Recruiting at 58 sites Weill Medical College of Cornell University · Boulder, Colorado and 58 other locations · NCT03217006

• Registry to improve outcomes after heart and chest surgeries

  This study is collecting information from patients who have heart and chest surgeries to see how different factors affect their recovery and overall outcomes.

  Recruiting CMC Ambroise Paré · Neuilly-sur-Seine, Île-de-France Region · NCT03209674

• Using the Carillon Mitral Contour System to treat heart failure with mild functional mitral regurgitation

  This study is testing if the Carillon Mitral Contour System can help people with heart failure and mild mitral regurgitation feel better compared to a similar procedure without the device.

  Recruiting at 61 sites Cardiac Dimensions Pty Ltd · Gilbert, Arizona and 91 other locations · NCT03142152

• Registry and biobank for arrhythmogenic ventricular cardiomyopathy

  This study is trying to gather information and samples from people with arrhythmogenic ventricular cardiomyopathy and their families to better understand the genetic causes of the condition and improve early diagnosis for those at risk.

  Recruiting at 2 sites Mayo Clinic · Rochester, Minnesota and 1 other locations · NCT03049254

• Preventing heart events in diabetic patients using specific medications

  This study tests whether high doses of certain heart medications can help prevent heart problems in people with Type 2 diabetes who don’t already have heart disease.

  Recruiting at 13 sites Phase 4 Medical University of Vienna · Mödling, Lower Austria and 20 other locations · NCT02817360

• Collecting tissue samples to study inflammation after heart surgery

  This study is collecting tissue samples from heart surgery patients to see how inflammation affects recovery and to find markers that could help understand heart disease better.

  Recruiting RWTH Aachen University · Aachen, North Rhine-Westphalia · NCT02488876

• Studying how genetic testing can improve medication use in patients

  This study is trying to see if using genetic testing can help doctors choose the right medications for patients with heart diseases, inflammatory bowel diseases, and autoimmune diseases to improve their treatment outcomes.

  Recruiting University of Chicago · Chicago, Illinois · NCT01280825

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How mechanical stress on heart muscle cells affects heart health

  Researchers are looking at how physical pressure on heart muscle cells changes their electrical signals and contractions, which could help people with high blood pressure or weakened hearts.

  NIH research University of California at Davis · Davis, United States · NIH-11307656

• Systems Genomics to Understand Congenital Heart Disease in People

  A patient-focused project will use genetics and computer data analysis to uncover why congenital heart disease happens and how it leads to health problems from infancy to adulthood.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11268906

• How mechanical load affects heart function and diseases

  This study is looking at how the pressure and strain on heart muscle cells affect their function, which could help us understand and treat heart problems like arrhythmias and heart failure better.

  NIH research University of California at Davis · Davis, United States · NIH-11045773

• Improving heart disease risk prediction for diverse populations

  This study is working to create better tools for predicting the risk of heart disease by looking at both your genes and other health factors, especially for people from different backgrounds, so that everyone can get fairer and more accurate health care.

  NIH research J. David Gladstone Institutes · San Francisco, United States · NIH-10864740

• Understanding how certain molecules affect recovery after heart surgery in children

  This study is looking at how certain molecules released during heart surgery for kids with congenital heart diseases affect their recovery and overall health, with the goal of finding better ways to help them heal.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10669290

Related topics

Quick answers

How many Heart Diseases clinical trials are recruiting right now?

55, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 45 countries. The most sites are in United States (27 trials), Germany (11 trials), United Kingdom (11 trials), Spain (9 trials), France (8 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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