A tool for managing stress and improving quality of life in cancer patients

My Wellbeing Guide, Technology Facilitated Behavioral Intervention for Depression Among Diverse Patients in Ambulatory Oncology

Not applicable Interventional Northwestern University · NCT05369429

This study is testing an online program called My Wellbeing Guide to see if it can help cancer patients feel less depressed and improve their quality of life.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment6516 (estimated)
Ages18 Years and up
SexAll
SponsorNorthwestern University Academic / other
Locations1 site (Chicago, Illinois)
Trial IDNCT05369429 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of My Wellbeing Guide, a psychosocial eHealth intervention designed to reduce depressive symptoms in cancer patients. The intervention employs cognitive behavioral therapy strategies delivered through an online application over a 7-week period, featuring animated videos, interactive activities, and written content. Participants will be randomized into either the intervention or a control group, with assessments conducted at baseline, post-intervention, and at 6- and 12-month follow-ups. The study aims to address the high prevalence of depression among cancer patients and improve their overall quality of life.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with a confirmed diagnosis of cancer and elevated depressive symptoms.

Not a fit: Patients without internet access or those who do not meet the eligibility criteria will not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly reduce depressive symptoms and enhance the quality of life for cancer patients.

How similar studies have performed: Other studies have shown success with similar eHealth interventions for managing depression in various populations, indicating potential for this approach in oncology.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

a) having been reached out to by the study team for recruitment; (b) planned treatment and follow-up within the NM or UHealth healthcare system; (c) ≥ 18 years of age; (d) medical chart confirmed diagnosis of a solid or hematological malignancy; (e) elevated depressive symptoms on the PROMIS CAT (score \> or = 55) within the last 3 months; (f) access to the internet; (g) willingness to be randomized; (h) able to read English or Spanish; (i) patients must have signed informed consent prior to registration on study

Exclusion Criteria:

Note: The investigators will not include any vulnerable populations in this study.

Where this trial is running

Chicago, Illinois

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions CancerAnxietyDepressive SymptomseHealthWellbeing
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.