Condition

Aphasia clinical trials and research

• 41Clinical trials
• 107NIH research projects
• 1New in 30 days
• 12Countries

Newest Aphasia clinical trials

All recruiting trials (41)

• See how language and general thinking networks help aphasia recovery

  This study tests whether language and general cognitive networks contribute to language recovery after stroke in people with aphasia.

  Recruiting Boston University Charles River Campus · Boston, Massachusetts · NCT07926347

• Aphasia rehabilitation with tDCS as added to speech therapy

  We are testing whether adding non-invasive brain stimulation (tDCS) to speech therapy helps people with Broca's aphasia after stroke more than speech therapy alone.

  Recruiting at 3 sites Phase 2/3 University of South Carolina · Charleston, South Carolina and 2 other locations · NCT07688551

• Tailoring rTMS for Post-Stroke Aphasia Based on Language Profile

  A non-drug brain stimulation approach is tested to see if customizing rTMS targets improves language recovery in people with aphasia after a left-brain stroke.

  Recruiting University of South Carolina · Columbia, South Carolina · NCT07608588

• LEXURE digital language therapy for post-stroke aphasia

  This trial will test whether using the LEXURE app helps adults with post-stroke aphasia improve language more than workbook-based practice.

  Recruiting at 8 sites Nunaps Inc · Ansan, Gyeonggi-do and 11 other locations · NCT07570264

• tDCS in Rehab for Stroke-Related Aphasia: A Practical Implementation

  This study tests whether a 20-minute anodal tDCS session paired with speech therapy can be integrated into routine inpatient and outpatient rehab for people who recently had a stroke and now have aphasia.

  Recruiting Casa Colina Hospital and Centers for Healthcare · Pomona, California · NCT07535788

• New tools to measure language, gestures, and everyday communication in people with aphasia

  This project will test new ways to measure language, gestures, and everyday communication skills in adults with aphasia after stroke.

  Recruiting IRCCS San Camillo, Venezia, Italy · Venice, VE · NCT07518576

• Decoding Mandarin speech features from brain-surface signals

  This project will try to decode imagined Mandarin speech, including lexical tones, from high-density brain-surface (ECoG) signals in adult patients who are having clinically indicated cortical electrode placement.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07460037

• Adding gestures to speech to help Cantonese speakers with aphasia name words

  This study will test whether combining hand gestures with speech therapy helps Cantonese-speaking people with aphasia name words better than speech-only therapy.

  Recruiting Hong Kong University · Hong Kong · NCT07455162

• Digital speech-therapy app Zenicom for subacute post-stroke aphasia in Korean speakers

  This trial will try the Zenicom digital speech-therapy app alongside conventional therapy to see if it helps Korean adults with aphasia after a recent (within 3 months) stroke.

  Recruiting at 3 sites Phase 2 Seoul National University Bundang Hospital · Seongnam-si and 2 other locations · NCT07397923

• High-intensity exercise to improve recovery after post-stroke aphasia

  This tests whether a 12-week high-intensity group exercise program helps people with post-stroke aphasia improve physical fitness, language, thinking, and mood compared with low-intensity exercise.

  Recruiting at 4 sites University of California, Berkeley · Berkeley, California and 3 other locations · NCT07281313

• Semantic Feature Analysis with versus without Metacognitive Strategy Training for adults with aphasia

  This trial will test whether adding metacognitive strategy training to semantic feature analysis helps adults with acquired aphasia name pictures more accurately and speak with more informative content.

  Recruiting Phase 2 Teachers College, Columbia University · New York, New York · NCT07036406

• Aphasia ID cards to help service workers understand people with aphasia

  This project will test whether showing service workers an aphasia identification card helps them better understand people with aphasia.

  Recruiting University of Massachusetts, Amherst · Springfield, Massachusetts · NCT06990997

• TMS plus language therapy to improve word-finding after left-hemisphere stroke

  Researchers will try excitatory transcranial magnetic stimulation combined with semantic feature analysis language therapy to improve word-finding in adults with aphasia after left-hemisphere stroke.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT06974279

• Using Transcranial Magnetic Stimulation and Language Therapy to Improve Speech After Stroke

  This study is testing if combining a brain stimulation technique with speech therapy can help people who have had a stroke improve their speech during the early recovery phase.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06968663

• Examining the link between motor skills and Turkish language abilities in stroke patients

  This study is testing how well motor skills and trunk control affect the Turkish language abilities of people who have had a stroke.

  Recruiting Izmir Bakircay University · Izmir · NCT06946082

• Rehabilitation combining language and metacognitive training for chronic vascular aphasia

  This study is testing a new rehab program that combines language and thinking skills training to see if it helps people with chronic vascular aphasia improve their communication after a stroke.

  Recruiting University Hospital, Toulouse · Toulouse · NCT06930131

• Using Transcranial Magnetic Stimulation and Language Therapy to Improve Mild Aphasia

  This study is testing whether combining brain stimulation with speech therapy can help people with mild aphasia after a stroke improve their speaking and understanding skills.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06842745

• Understanding reading difficulties in stroke survivors and older adults

  This study looks at how reading problems, called alexia, affect stroke survivors and older adults to see how their brains work and how we can help them better.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT06700005

• Educational support program for bilingual individuals with progressive aphasia and their caregivers

  This study is testing a support program for bilingual people with progressive aphasia and their caregivers to see if it helps them communicate better and cope with the challenges of the condition.

  Recruiting Early Phase 1 University of Texas at Austin · Austin, Texas · NCT06511752

• Identifying brain recovery markers in stroke patients with aphasia

  This study is trying to find out how brain recovery affects language skills in stroke patients with aphasia to help improve their treatment and recovery.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06471127

• Using non-invasive nerve stimulation to improve language recovery in stroke survivors with aphasia

  This study is testing if a new non-invasive treatment using nerve stimulation can help stroke survivors with long-term language difficulties improve their communication skills when combined with speech therapy.

  Recruiting Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield · NCT06403475

• Community choir singing for people with chronic post-stroke aphasia

  This study tests if a 12-week choir singing program can help people with long-term speech difficulties after a stroke communicate better and feel more connected compared to regular care.

  Recruiting University of Ottawa · Tampa, Florida and 3 other locations · NCT06368323

• Investigating cognitive functioning in adults with aphasia and the general population

  This study is trying to see how thinking skills in adults with aphasia compare to those in the general population by testing memory, learning, and language abilities.

  Recruiting Laboratory of Psychological and Educational Tests · Gdansk, Pomeranian Voivodeship · NCT06365658

• Recursive self-feedback to help speech after a stroke in aphasia

  Researchers are testing whether stroke survivors with aphasia can improve their everyday speech by listening to and correcting their own spoken responses using tablet-based, self-guided feedback.

  Recruiting University of South Florida · Tampa, Florida · NCT06323629

• Combining exercise with targeted therapy to improve reading after stroke

  This study is testing if combining exercise with reading therapy can help stroke survivors improve their reading skills and overall quality of life.

  Recruiting Kessler Foundation · West Orange, New Jersey · NCT06213272

• Exploring motor imagery abilities in individuals with aphantasia

  This study is testing if a brain stimulation treatment can help people with aphantasia improve their ability to imagine movements compared to those who can visualize normally.

  Recruiting Hôpital le Vinatier · Bron · NCT06140940

• Using brain stimulation to improve language skills after stroke

  This study is testing whether a type of brain stimulation can help people with language problems after a stroke improve their speaking and understanding skills.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06092814

• Using brain stimulation to improve language recovery in stroke patients with aphasia

  This study is testing whether a new brain stimulation technique can help stroke survivors with aphasia improve their language skills when combined with speech therapy.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT06048159

• Telemedicine therapy for improving language skills in stroke patients with aphasia

  This study is testing two different online language therapies for stroke patients with aphasia to see which one helps improve their speaking and naming skills better.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05845047

• Effects of speech-language intervention on bilingual speakers with primary progressive aphasia

  This study tests if special speech therapy designed for bilingual people can help those with primary progressive aphasia communicate better in both of their languages.

  Recruiting at 2 sites University of Texas at Austin · Austin, Texas and 2 other locations · NCT05741853

• Evaluating new treatment methods for word-finding difficulties in stroke-related aphasia

  This study is testing new ways to help people with stroke-related language difficulties improve their word-finding skills through online treatment sessions.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05653466

• Improving naming treatment for people with aphasia after stroke

  This study tests new ways to help people with aphasia after a stroke improve their naming skills and use them in daily life.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05653440

• Exploring the effects of TMS on language processing in stroke and aphasia

  This study tests whether Transcranial Magnetic Stimulation (TMS) can help improve language skills in people who have had a stroke and struggle with aphasia, as well as in healthy individuals.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT05425615

• Training to improve sentence production in people with aphasia

  This study is testing a new way to help people with aphasia improve their ability to create and understand sentences using special training techniques.

  Recruiting Purdue University · West Lafayette, Indiana · NCT05415501

• Understanding speech difficulties in people with aphasia after a stroke

  This study is trying to understand how brain activity affects speech difficulties in people with aphasia after a stroke, to see if new training methods can help them speak better.

  Recruiting The University of Texas at Dallas · Irvine, California and 2 other locations · NCT04742894

• Telerehabilitation for aphasia treatment

  This study tests whether a new online therapy for people with aphasia after a stroke works better than traditional in-person therapy.

  Recruiting University of South Carolina · Columbia, South Carolina · NCT04682223

• Intensive rehabilitation for speech and language recovery after stroke

  This study is testing whether a two-week intensive speech and language therapy program can help people with speech difficulties after a stroke improve their communication and quality of life.

  Recruiting Karolinska Institutet · Uppsala · NCT04604444

• Enhancing speech-language treatment for stroke patients with aphasia using brain stimulation

  This study is testing if adding brain stimulation to speech therapy can help stroke survivors with aphasia improve their language skills better than just therapy alone.

  Recruiting University of New Mexico · Albuquerque, New Mexico · NCT04432883

• Using brain stimulation to improve language recovery in stroke patients with aphasia

  This study is testing if a new brain stimulation technique can help stroke patients with aphasia recover their language skills better than regular therapy alone.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT04375722

• Using brain stimulation to improve language skills in people with chronic aphasia after a stroke

  This study is testing if a brain stimulation treatment combined with speech therapy can help improve language skills in people who have chronic aphasia after a stroke.

  Recruiting City University of New York · New York, New York · NCT04142866

• Using escitalopram to enhance language therapy for stroke patients with aphasia

  This study is testing if taking escitalopram can help stroke patients with aphasia improve their language skills better when combined with speech therapy.

  Recruiting at 3 sites Phase 2 Johns Hopkins University · Baltimore, Maryland and 2 other locations · NCT03843463

NIH-funded research (newest 40 of 107)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Communication Bridge: Improving language therapy for people with primary progressive aphasia

  A proven language-therapy program called Communication Bridge helps people with primary progressive aphasia improve and maintain how they communicate with others.

  NIH research University of Chicago · Chicago, United States · NIH-11601788

• Neural signals linked to recovery from aphasia after stroke

  This grant follows people who recently had a stroke and aphasia to understand why some recover language abilities better than others.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11565238

• Bilingualism and language resilience in Hispanic people with primary progressive aphasia

  Researchers compare different bilingual experiences to see how they relate to language decline and thinking skills in Hispanic adults with primary progressive aphasia.

  NIH research University of Texas at Austin · Austin, United States · NIH-11491123

• Functional reorganization of language and general brain networks in aphasia

  This project studies how language areas and general brain networks work together to help people recover language after a stroke, by looking at brain activity and responses to language tasks.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11465093

• eSANA: revealing and improving AAC use after stroke for aphasia

  A project to explore how people with aphasia after a stroke can best use augmentative and alternative communication (AAC) during early rehabilitation.

  NIH research University of South Florida · Tampa, United States · NIH-11454006

• Cortical Organization of Syntax in Aphasia

  A patient-facing study to understand how brain injury affects sentence structure and help people with aphasia communicate more clearly.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11448593

• Music-based intervention to help people with aphasia recover language and thinking skills after stroke

  A Purdue-led study tests whether listening to music can help adults with aphasia after a stroke improve language and thinking abilities.

  NIH research Purdue University · West Lafayette, United States · NIH-11443727

• Communication Bridge helps people with primary progressive aphasia talk more clearly

  Aimed at people with primary progressive aphasia, this project tests a speech-language and psychosocial program delivered by telepractice to improve daily communication and quality of life.

  NIH research University of Chicago · Chicago, United States · NIH-11412609

• Computational modeling of language in bilingual adults after stroke and with neurodegenerative conditions

  A computer-based study will model how bilingual Spanish-English speakers experience language changes after stroke and with neurodegenerative disorders, to inform better care for affected patients.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11402621

• tDCS plus speech therapy to improve language in people with aphasia

  A large, patient-facing study will test whether adding transcranial direct current stimulation to speech therapy helps people with aphasia after a stroke communicate better.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11400528

• Transcranial current therapy for language in progressive aphasia

  A world-class team is testing a painless brain-stimulation method to help people with primary progressive aphasia say more words and names.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11399300

• Improving communication support for people with primary progressive aphasia

  This project improves and delivers an evidence-based speech and communication program to help people with primary progressive aphasia and their care partners, including through telehealth.

  NIH research University of Chicago · Chicago, United States · NIH-11398724

• Brain aging and aphasia after stroke

  We’re learning how aging affects language problems after a stroke and how brain aging markers might help predict and improve care for people with aphasia.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11398021

• Restoring speech with a brain implant for stroke-related aphasia

  A study at UC Davis aims to help people who have language trouble after a stroke by using a tiny brain implant to turn brain signals into spoken words.

  NIH research University of California at Davis · Davis, United States · NIH-11397115

• Primary Progressive Aphasia: How speech and language decline happens and progresses

  This grant studies a brain disease called primary progressive aphasia to understand why speech and language slip up over time.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11395213

• Retrieval Practice for Aphasia Rehab: How to help people with aphasia learn better

  Aphasia patients could benefit from a learning approach called retrieval practice that helps improve word retrieval and language skills.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11393830

• Cerebellar stimulation to help speech after stroke

  A Johns Hopkins study tests whether applying gentle electrical stimulation to the cerebellum, when paired with speech therapy, can improve language skills in people who have aphasia after a stroke.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11393141

• Predicting language recovery after stroke using AI

  A new AI-based project uses brain scans and personal data to forecast how aphasia may progress after a stroke, with the goal of guiding personalized treatment.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11387931

• Neural signals of getting speech back after stroke

  This grant studies how the brain changes as people recover speech after a stroke, to help predict and improve language recovery.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11381219

• Noninvasive brain stimulation to improve word‑finding in primary progressive aphasia

  This project uses gentle, noninvasive brain stimulation (tDCS) to try to help people with primary progressive aphasia who have trouble finding words.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11378070

• Why one side of the brain loses language in primary progressive aphasia

  It looks at how different brain diseases cause one-sided language loss in people with primary progressive aphasia and which imaging, fluid, and genetic signs go along with each cause.

  NIH research Northwestern University · Chicago, United States · NIH-11372834

• ANCHOR: Helping people with aphasia stay connected with friends

  A small, early-stage study will test whether a three-session, therapist-guided program plus a supportive online platform can help people with aphasia stay connected with friends during early rehabilitation.

  NIH research Bowling Green State University · Bowling Green, United States · NIH-11371983

• How the brain recovers language after a stroke

  This research follows people with aphasia after stroke to find brain and behavior signs that predict who will regain speech and language.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11364679

• Electrical Field Guided TMS and Constraint Induced Language Therapy for Subacute Post-Stroke Aphasia

  This study tests a targeted brain stimulation plus speech therapy approach to help people with language loss after a recent stroke.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11362269

• Neurocognitive factors behind speech problems in aphasia after stroke

  This NIH grant aims to understand why some people have trouble forming fluent sentences after a stroke and how brain timing and spelling-related processes contribute to those difficulties.

  NIH research Univ of Maryland, College Park · College Park, United States · NIH-11355623

• Longitudinal brain imaging in a form of speech-language degeneration (nfvPPA)

  A Mayo Clinic study follows people with non-fluent/agrammatic primary progressive aphasia over time to map brain changes using advanced imaging and blood biomarkers.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11350994

• High-intensity exercise to improve language after stroke

  This project looks at whether a tailored high-intensity exercise program can help people with aphasia after stroke improve their speaking, thinking, and well-being.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11332836

• Early language and thinking changes in older African American adults and primary progressive aphasia

  This project looks for early changes in speech and thinking by recording natural speech and measuring pupil responses in older African American adults at risk for dementia.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11289462

• Aerobic exercise plus targeted speech exercises to improve reading after stroke

  Short bouts of aerobic exercise done before focused speech-based reading work may help people with post-stroke aphasia read more accurately and regain independence.

  NIH research Kessler Foundation, INC. · East Hanover, UNITED STATES · NIH-11285474

• Bilingualism and language resilience in Hispanic adults with primary progressive aphasia

  This project will learn how different bilingual experiences affect thinking and language skills in Hispanic adults with primary progressive aphasia.

  NIH research University of Texas at Austin · Austin, United States · NIH-11285140

• Tracking brain changes to improve recovery from aphasia after a stroke

  This study is looking at how brain scans can help us understand and improve language recovery for people with aphasia after a stroke, so if you've experienced this, your participation could help find better ways to support your healing.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11276826

• Imaging TDP-43 changes in primary progressive aphasia and genetic frontotemporal dementia

  This project aims to find brain imaging markers of the TDP-43 protein in people with primary progressive aphasia and inherited frontotemporal dementia so doctors can better tell these cases apart from tau-related disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11265593

• Adaptive computer practice to improve word-finding in aphasia

  This project uses computer programs that change practice difficulty to help people with aphasia find words more easily and keep those gains over time.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11260184

• Better tests of how people with aphasia pay attention to sounds

  This project uses a short hearing-based attention test to help tailor therapy for people with aphasia after stroke.

  NIH research Purdue University · West Lafayette, United States · NIH-11251312

• Brain-wave testing to pinpoint listening challenges in aphasia

  This project uses EEG while people with aphasia listen to natural speech to identify which sound and word cues their brains track.

  NIH research University of Houston · Houston, United States · NIH-11249235

• Understanding how sleep affects language recovery after a stroke

  This study is looking at how sleep affects language recovery in people with aphasia after a stroke, to see if improving sleep can help make language therapy more effective.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11243713

• Improving language recovery in stroke patients with brain network techniques

  This study is looking at how we can help people with aphasia, a language problem that can happen after a stroke, by using special techniques to boost the brain's language networks, so they can improve their speaking and communication skills.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11243305

• Prefrontal brain stimulation to ease post-stroke fatigue and help language and attention in aphasia

  This project uses gentle electrical stimulation to the front of the brain to help people with aphasia after stroke feel less tired and improve attention and language.

  NIH research Syracuse University · Syracuse, United States · NIH-11231739

• Using a portable, clinic-friendly brain scan to map language after stroke

  This project compares a quiet, clinic-friendly brain scanner (fNIRS) with MRI to map language areas and track changes during rehabilitation for people with post-stroke aphasia.

  NIH research Veterans Health Administration · Pittsburgh, United States · NIH-11220708

• Verdiperstat for semantic variant primary progressive aphasia (svPPA) linked to TDP‑43

  Adults with semantic variant primary progressive aphasia (svPPA) will receive Verdiperstat or placebo to find safe doses and look for early signs it affects disease markers.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11179299

Related topics

Quick answers

How many Aphasia clinical trials are recruiting right now?

41, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (30 trials), France (2 trials), South Korea (2 trials), Turkey (Türkiye) (1 trial), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 2/3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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