Using non-invasive nerve stimulation to improve language recovery in stroke survivors with aphasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the feasibility, safety, and tolerability of Transcutaneous Vagus Nerve Stimulation (tVNS) in individuals with chronic aphasia following a stroke. tVNS is a non-invasive technique that stimulates a branch of the vagus nerve through the skin of the ear, potentially aiding language recovery when combined with computer-based Speech and Language Therapy (SLT). The study aims to assess whether this approach can enhance communication abilities in stroke survivors who have experienced aphasia for more than six months. The findings may support the development of larger randomized controlled trials in the future.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Supratentorial stroke at least 6 months prior to recruitment
* Aphasia (with word finding difficulties)
* Ability to engage in the programme (support can be provided for cognitive or receptive difficulties)
* Sufficient vision to engage in the computer-based SLT programme

Exclusion Criteria:

* Implanted devices (e.g. pacemaker) or implanted stimulation devices
* Currently receiving a programme of Speech and Language Therapy (SLT)
* Damage to the vagus nerve
* Symptomatic bradycardia/ 2nd or 3rd heart block
* Pregnancy
* Unable to speak English
* Severe deafness (despite using hear aids)

Where it's running

• Sheffield Teaching Hospitals NHS Foundation Trust
  Sheffield, United Kingdom Recruiting

Study contacts

• Principal investigator: Dr Ali Ali — Sheffield Teaching Hospitals NHS Foundation Trust
• Study coordinator: Dr Ali Ali
• Email: ali.ali@sheffield.ac.uk
• Phone: 01142159114

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.