LEXURE digital language therapy for post-stroke aphasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, randomized, evaluator-blinded confirmatory trial comparing a digital therapeutic (LEXURE) to a workbook-based active comparator in people with post-stroke aphasia. Eligible adults (≥19 years) at least 3 months after ischemic or hemorrhagic stroke with an Aphasia Quotient of 26–90 will be randomized 1:1. The LEXURE group will do ~30-minute digital training sessions five times weekly for 10 weeks while the control group will follow matched workbook tasks on the same schedule. Primary outcomes use the K-WAB/PK-WAB-R scored by independent, blinded assessors to measure language change and safety over the intervention period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosed with hemorrhagic or ischemic stroke
2. At least 3 months have elapsed since stroke onset
3. History of aphasia resulting from stroke
4. Aphasia Quotient (AQ) score between 26 and 90 (inclusive) on the Korean version of the Western Aphasia Battery (K-WAB) or the Paradise Korean version of the Western Aphasia Battery-Revised (PK-WAB-R)
5. Adults aged 19 years or older
6. Native Korean speakers
7. Able to use the investigational device or perform workbook-based training without difficulty
8. Willing to participate voluntarily and provide written informed consent

Exclusion Criteria:

1. Diagnosed with language impairment due to causes other than stroke (e.g., traumatic brain injury, brain tumor, or neurodegenerative disease)
2. History of language impairment due to developmental disorders
3. Currently receiving speech-language therapy or participating in another clinical trial related to language function
4. Currently receiving medication for severe psychiatric disorders (e.g., bipolar disorder, major depressive disorder, schizophrenia, alcohol dependence, or substance abuse)
5. Illiterate individuals
6. Individuals deemed unsuitable for participation in this study by the investigator
7. Severe cognitive impairment that would interfere with understanding or performing the study interventions

Where it's running

• Inje University Busan Paik Hospita
  Busan, South Korea Recruiting
• Hallym University Chuncheon Sacred Heart Hospital
  Chuncheon, South Korea Recruiting
• Keimyung University Dongsan Hospital
  Daegu, South Korea Recruiting
• Chonnam National University Hospital
  Gwangju, South Korea Recruiting
• Inje University Ilsan Paik Hospital
  Ilsan, South Korea Recruiting
• Asan Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Suekyung Jung
• Email: skjung@nunaps.com
• Phone: +82-2-488-6542

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Tailoring rTMS for Post-Stroke Aphasia Based on Language Profile

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• tDCS in Rehab for Stroke-Related Aphasia: A Practical Implementation

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• New tools to measure language, gestures, and everyday communication in people with aphasia

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• Decoding Mandarin speech features from brain-surface signals

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  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07460037

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.