Evaluating new treatment methods for word-finding difficulties in stroke-related aphasia
Official title: Integrating Complementary Learning Principles in Aphasia Rehabilitation Via Adaptive Modeling (Sub-study 2: Adaptive Trial Scheduling)
Run by University of Pittsburgh · NCT05653466 · Data updated 2026-11-12
This study is testing new ways to help people with stroke-related language difficulties improve their word-finding skills through online treatment sessions.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 32 (estimated) |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Status | Recruiting |
| Started | December 6, 2023 |
| Main results expected | January 31, 2027 |
| Study ends | January 31, 2028 |
| Registry record updated | December 11, 2025 |
| Trial ID | NCT05653466 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with chronic aphasia following a left hemisphere stroke who have access to high-speed internet and can participate in telehealth.
✕Probably not a fit
Patients with significant language comprehension impairments or other neurological diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to improve treatment for anomia, a common language disorder resulting from stroke, by comparing adaptive trial scheduling to non-adaptive approaches. A total of 32 participants with chronic aphasia will be enrolled in a randomized crossover design, receiving different treatment conditions over a year via telehealth. Each participant will undergo assessments and treatment sessions designed to enhance long-term retention and practical use of naming abilities in daily life. The study will evaluate the effectiveness of these novel treatment approaches in a real-world clinical context.
Why it matters
Potential benefit: If successful, this study could lead to more effective rehabilitation strategies for individuals with aphasia, improving their communication abilities and quality of life.
How similar studies have gone: While there have been studies on aphasia treatment, the specific adaptive trial scheduling approach being evaluated in this study is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Existing diagnosis of chronic (\>6 months) aphasia subsequent to left hemisphere stroke. * Impaired performance on 2/8 sections of the Comprehensive Aphasia Test. * Must have access to a high-speed internet connection and be able to participate in telehealth. Exclusion Criteria: * History of other acquired or progressive neurological disease. * Significant language comprehension impairments * Unmanaged drug / alcohol dependence. * Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.
Where it's running
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Language Rehab and Cognition Lab, Department of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh
Pittsburgh, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: William Evans, PhD — University of Pittsburgh
- Study coordinator: Alyssa Kelly, M.A., CCC-SLP
- Email: ank155@pitt.edu
- Phone: 412-648-3274
Similar studies
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This trial will try the Zenicom digital speech-therapy app alongside conventional therapy to see if it helps Korean adults with aphasia after a recent (within 3 months) stroke.
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This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.