Electrical Field Guided TMS and Constraint Induced Language Therapy for Subacute Post-Stroke Aphasia
Official title: Electrical Field Guided TMS and Constraint Induced Language Therapy to TreatPost-Stroke Aphasia in the Subacute Stage
Funded at University of Pennsylvania · NIH-11362269 · Data updated 2026-11-12
This study tests a targeted brain stimulation plus speech therapy approach to help people with language loss after a recent stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 7, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $672,187 |
| NIH project number | 5R01DC021060-03 |
| Project ID | NIH-11362269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with subacute aphasia due to recent stroke who can participate in a structured therapy program and brain stimulation sessions.
✕Less likely to help
Individuals with aphasia from non-stroke causes, very severe impairments, or contraindications to brain stimulation may not benefit.
What this research studies
In this study, people with aphasia after a recent stroke will receive a personalized form of brain stimulation called continuous Theta Burst Stimulation together with a modified speech therapy program. Participants are randomly assigned to receive real stimulation with therapy or a sham (placebo) stimulation with therapy, over 10 treatment days. Researchers will measure language ability before, right after treatment, and several months later, and will look for brain network changes that relate to response. The goal is to determine if this combined approach improves language function and to understand why it works in the subacute period.
Why it matters
Potential benefit: If successful, patients may regain more language ability after a stroke and improve communication in daily life.
How similar studies have gone: Previous small studies suggest potential benefits in chronic aphasia; this trial tests efficacy in the subacute stage with rigorous design.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Coslett, H Branch — University of Pennsylvania
- Study coordinator: Coslett, H Branch
Related research
Other NIH-funded projects on the same topics.
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Predicting language recovery after stroke using AI
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Neural signals of getting speech back after stroke
This grant studies how the brain changes as people recover speech after a stroke, to help predict and improve language recovery.
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How the brain recovers language after a stroke
This research follows people with aphasia after stroke to find brain and behavior signs that predict who will regain speech and language.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.