Condition

Primary Progressive Aphasia clinical trials and research

• 13Clinical trials
• 24NIH research projects
• 4Countries

Newest Primary Progressive Aphasia clinical trials

All recruiting trials (13)

• Stimulating the aging brain with brain and sensory stimulation for language), wait

  This study tests whether transcranial alternating current stimulation (tACS) and multisensory stimulation can improve verbal short-term memory in people with Primary Progressive Aphasia.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT07650188

• Predicting disease progression in dementia using biomarkers and modeling

  This study is trying to create a tool that helps predict how dementia will progress in people with mild cognitive impairment and different types of dementia, like Alzheimer's and Lewy Body Disease, by looking at brain scans, body fluids, and mental tests.

  Recruiting University Health Network, Toronto · North York, Ontario and 3 other locations · NCT06529744

• Educational support program for bilingual individuals with progressive aphasia and their caregivers

  This study is testing a support program for bilingual people with progressive aphasia and their caregivers to see if it helps them communicate better and cope with the challenges of the condition.

  Recruiting Early Phase 1 University of Texas at Austin · Austin, Texas · NCT06511752

• Evaluating speech therapy for Primary Progressive Aphasia

  This study is testing if speech therapy and a special app can help adults with mild to moderate Primary Progressive Aphasia communicate better.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT06191198

• Effects of speech-language intervention on bilingual speakers with primary progressive aphasia

  This study tests if special speech therapy designed for bilingual people can help those with primary progressive aphasia communicate better in both of their languages.

  Recruiting at 2 sites University of Texas at Austin · Austin, Texas and 2 other locations · NCT05741853

• Improving language skills in people with aphasia

  This study is testing a new language treatment for people with aphasia to see if it helps them improve their speaking and understanding skills.

  Recruiting University of Arizona · Tucson, Arizona · NCT05443633

• Using brain stimulation to improve language in patients with primary progressive aphasia

  This study is testing if using brain stimulation along with language therapy can help people with primary progressive aphasia improve their naming and spelling skills.

  Recruiting at 3 sites Phase 2 Johns Hopkins University · Baltimore, Maryland and 2 other locations · NCT05386394

• Semantic rehabilitation for patients with primary progressive semantic aphasia

  This study is testing a personalized speech therapy program to see if it can help people with primary progressive semantic aphasia improve their understanding and use of words.

  Recruiting University Hospital, Toulouse · Toulouse · NCT04957537

• Improving language function in patients with Primary Progressive Aphasia

  This study is testing whether a new treatment that combines brain stimulation with language therapy can help people with Primary Progressive Aphasia improve their language skills.

  Recruiting University of Arizona · Tucson, Arizona · NCT04920318

• Using electrical stimulation to improve language function in patients with logopenic variant PPA

  This study is testing if a special type of brain stimulation can help people with logopenic variant Primary Progressive Aphasia improve their language skills when combined with a language therapy.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT03887481

• Understanding two types of progressive speech disorders

  This study is trying to tell apart two types of speech disorders in people with progressive speech problems to better understand their causes and what they might mean for future health.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03313011

• Investigating brain changes in patients with progressive apraxia of speech

  This study is trying to see how changes in the brain affect speech difficulties over time in people with progressive apraxia of speech.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT01818661

• Understanding language changes in primary progressive aphasia

  This study is trying to understand how language skills change in people with primary progressive aphasia to help raise awareness and support future treatments.

  Recruiting Northwestern University · Chicago, Illinois · NCT00537004

NIH-funded research (24)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Communication Bridge: Improving language therapy for people with primary progressive aphasia

  A proven language-therapy program called Communication Bridge helps people with primary progressive aphasia improve and maintain how they communicate with others.

  NIH research University of Chicago · Chicago, United States · NIH-11601788

• Bilingualism and language resilience in Hispanic people with primary progressive aphasia

  Researchers compare different bilingual experiences to see how they relate to language decline and thinking skills in Hispanic adults with primary progressive aphasia.

  NIH research University of Texas at Austin · Austin, United States · NIH-11491123

• Communication Bridge helps people with primary progressive aphasia talk more clearly

  Aimed at people with primary progressive aphasia, this project tests a speech-language and psychosocial program delivered by telepractice to improve daily communication and quality of life.

  NIH research University of Chicago · Chicago, United States · NIH-11412609

• Transcranial current therapy for language in progressive aphasia

  A world-class team is testing a painless brain-stimulation method to help people with primary progressive aphasia say more words and names.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11399300

• Improving communication support for people with primary progressive aphasia

  This project improves and delivers an evidence-based speech and communication program to help people with primary progressive aphasia and their care partners, including through telehealth.

  NIH research University of Chicago · Chicago, United States · NIH-11398724

• Primary Progressive Aphasia: How speech and language decline happens and progresses

  This grant studies a brain disease called primary progressive aphasia to understand why speech and language slip up over time.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11395213

• Noninvasive brain stimulation to improve word‑finding in primary progressive aphasia

  This project uses gentle, noninvasive brain stimulation (tDCS) to try to help people with primary progressive aphasia who have trouble finding words.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11378070

• Why one side of the brain loses language in primary progressive aphasia

  It looks at how different brain diseases cause one-sided language loss in people with primary progressive aphasia and which imaging, fluid, and genetic signs go along with each cause.

  NIH research Northwestern University · Chicago, United States · NIH-11372834

• Longitudinal brain imaging in a form of speech-language degeneration (nfvPPA)

  A Mayo Clinic study follows people with non-fluent/agrammatic primary progressive aphasia over time to map brain changes using advanced imaging and blood biomarkers.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11350994

• Early language and thinking changes in older African American adults and primary progressive aphasia

  This project looks for early changes in speech and thinking by recording natural speech and measuring pupil responses in older African American adults at risk for dementia.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11289462

• Bilingualism and language resilience in Hispanic adults with primary progressive aphasia

  This project will learn how different bilingual experiences affect thinking and language skills in Hispanic adults with primary progressive aphasia.

  NIH research University of Texas at Austin · Austin, United States · NIH-11285140

• Imaging TDP-43 changes in primary progressive aphasia and genetic frontotemporal dementia

  This project aims to find brain imaging markers of the TDP-43 protein in people with primary progressive aphasia and inherited frontotemporal dementia so doctors can better tell these cases apart from tau-related disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11265593

• Verdiperstat for semantic variant primary progressive aphasia (svPPA) linked to TDP‑43

  Adults with semantic variant primary progressive aphasia (svPPA) will receive Verdiperstat or placebo to find safe doses and look for early signs it affects disease markers.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11179299

• Communication Bridge: improving communication for people with primary progressive aphasia

  We are trying a speech and caregiver-focused program delivered by telepractice to help people living with primary progressive aphasia communicate better in everyday life.

  NIH research University of Chicago · Chicago, United States · NIH-11174374

• Understanding brain changes in a type of aphasia

  This project looks at brain changes over time in people with a specific type of language disorder called non-fluent/agrammatic primary progressive aphasia.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11137609

• Gentle electrical brain stimulation to help word-finding in primary progressive aphasia

  This project combines gentle electrical brain stimulation with speech exercises to help people with primary progressive aphasia (PPA) find words more easily.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11124741

• Exploring how bilingualism affects cognitive health in Hispanics with language disorders

  This study is looking at how being bilingual might help Hispanic individuals with primary progressive aphasia, a type of dementia that affects language, by exploring how their language skills and experiences can influence their brain's ability to stay strong against decline.

  NIH research University of Texas at Austin · Austin, United States · NIH-11082935

• How bilingualism affects cognitive health in Hispanics with language disorders

  This study is looking at how being bilingual might help Hispanic people with primary progressive aphasia, a type of dementia that affects language, by exploring how their language skills and experiences can influence their brain's ability to cope with the condition.

  NIH research University of Texas at Austin · Austin, United States · NIH-10990995

• Dynamic brain imaging of speech in progressive aphasia

  A study test uses advanced brain imaging to understand how speech changes in people with primary progressive aphasia.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10985021

• Personalized prognosis and care for primary progressive aphasia

  This project will use brain scans and molecular imaging to help predict how language skills will change over time for people with primary progressive aphasia.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10973968

• Testing a new treatment for a type of progressive language disorder linked to brain degeneration.

  This study is looking at how safe and helpful a new medication called Verdiperstat is for people with semantic variant primary progressive aphasia (svPPA), and if you join, you might receive either the medication or a placebo without knowing which one, to help researchers learn more about treating this condition.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10893644

• How primary progressive aphasia changes language, thinking, and the brain over time

  Following people with primary progressive aphasia to track changes in speech, thinking, brain scans, and biological markers over time.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10795771

• Using noninvasive brain stimulation to improve language function in patients with primary progressive aphasia

  This study is exploring how a gentle brain stimulation technique called tDCS can help people with primary progressive aphasia, a condition that affects language skills in those with Alzheimer's or frontotemporal dementia, by boosting their brain's ability to communicate better.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10670952

• Improving diagnosis and outcomes for primary progressive aphasia

  This study is looking at ways to better understand and diagnose primary progressive aphasia (PPA), a condition that affects how people communicate, by using advanced brain imaging techniques, so that doctors can provide better care and support for those living with PPA.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10634041

Related topics

Quick answers

How many Primary Progressive Aphasia clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (11 trials), Canada (2 trials), France (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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