Rehabilitation combining language and metacognitive training for chronic vascular aphasia
Official title: Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
Run by University Hospital, Toulouse · NCT06930131 · Data updated 2026-11-12
This study is testing a new rehab program that combines language and thinking skills training to see if it helps people with chronic vascular aphasia improve their communication after a stroke.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 18 (estimated) |
| Sponsor | University Hospital, Toulouse Academic / other |
| Locations | 1 site (Toulouse) |
| Status | Recruiting |
| Started | February 21, 2025 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT06930131 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals who have experienced their first cerebral infarction and are in the chronic phase of recovery, with mild to moderate aphasia.
✕Probably not a fit
Patients with pre-existing cognitive impairments, severe psychiatric conditions, or those unable to undergo MRI may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effects of a combined rehabilitation approach that integrates linguistic and metacognitive training for patients with chronic vascular aphasia following a stroke. It aims to improve language performance and enhance functional cerebral connectivity networks, potentially benefiting both verbal and non-verbal communication skills. The study is a prospective, randomized controlled, open-label, single-centre trial conducted at the University Hospital of Toulouse. Participants will undergo semantic rehabilitation to address word-finding difficulties associated with aphasia.
Why it matters
Potential benefit: If successful, this approach could significantly enhance communication abilities and overall quality of life for patients with chronic vascular aphasia.
How similar studies have gone: While studies have explored linguistic and metacognitive training separately, this combined approach is novel and has not been previously assessed in post-stroke aphasic patients.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * First cerebral infarction * Chronic phase (\> 3 months) * Patient affiliated to a health insurance scheme * Usual french language * Severity score measures using the Boston Diagnostic Aphasia Examination battery scale corresponding to the mild or moderate level (score greater than or equal to 2) Exclusion Criteria: * Contraindication to undergoing brain MRI * Cognitive impairment pre-existing stroke (CQI code \> 3.4) (Law et al., 1995) * Chronic alcohol or drug abuse * Unstabilised psychiatric illness * Uncorrected sensory deficits * Diagnosed as having a progressive general pathology
Where it's running
-
University Hospital of Toulouse
Toulouse, France Recruiting
Study contacts
- Study coordinator: Lola DANET
- Email: danet.l@chu-toulouse.fr
- Phone: 05 61 77 76 86
Similar studies
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Digital speech-therapy app Zenicom for subacute post-stroke aphasia in Korean speakers
This trial will try the Zenicom digital speech-therapy app alongside conventional therapy to see if it helps Korean adults with aphasia after a recent (within 3 months) stroke.
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This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
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TMS plus language therapy to improve word-finding after left-hemisphere stroke
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.