Understanding speech difficulties in people with aphasia after a stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the neural mechanisms underlying vocal sensorimotor impairments in individuals with aphasia resulting from chronic left hemisphere strokes. It aims to identify objective biomarkers through behavioral assessments, EEG, and fMRI to better understand the role of auditory feedback in speech production and control. By comparing individuals with aphasia to age- and gender-matched healthy controls, the study seeks to refine treatment strategies and improve recovery outcomes for patients. The intervention involves visual feedback training to enhance speech motor output.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A total of 50 individuals with aphasia due to chronic left hemisphere stroke (\> 6 months post-stroke) and 50 age- and gender-matched healthy control subjects will be recruited in this study. The general inclusion criteria for all subjects include: age range 21-75 years, right-handed, and native speaker of English. The aphasic subjects have previously undergone neuro-psychological speech/language testing and have been diagnosed with one type of aphasia (e.g., Broca's, Wernicke's, conduction or anomic). Subjects in the control group will meet the inclusion criteria with having normal voice, speech, language, and hearing function and no history of neurological and psychiatric disorder. We expect that a significant proportion of aphasic patients will show symptoms associated with Apraxia of Speech (AOS) or dysarthria; however, these patients will not be excluded unless their deficits will preclude them from performing the experimental tasks.

Exclusion Criteria:

* Subjects with moderate to severe hearing, memory, and/or cognitive impairments will be excluded for both groups. In addition, subjects with history of peripheral laryngeal disorders (e.g., paresis or vocal fold paralysis) will be excluded. Subjects will undergo safety screening and will be excluded if there are any factors counter-indicative for EEG and/or MRI scanning.

Where it's running

• The University of Texas at Dallas
  Richardson, Texas, United States Recruiting
• University of California Irvine
  Irvine, California, United States Not yet recruiting
• University of South Carolina
  Columbia, South Carolina, United States Not yet recruiting

Study contacts

• Study coordinator: Roozbeh Behroozmand, PhD
• Email: roozbeh.behroozmand@utdallas.edu
• Phone: 9728833062

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• LEXURE digital language therapy for post-stroke aphasia

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• tDCS in Rehab for Stroke-Related Aphasia: A Practical Implementation

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• New tools to measure language, gestures, and everyday communication in people with aphasia

  This project will test new ways to measure language, gestures, and everyday communication skills in adults with aphasia after stroke.

  Recruiting IRCCS San Camillo, Venezia, Italy · Venice, VE · NCT07518576

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.