Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 18 to 89

Semantic Feature Analysis with versus without Metacognitive Strategy Training for adults with aphasia

Official title: Comparing the Effectiveness of Traditional Semantic Feature Analysis (SFA) Versus SFA Plus Metacognitive Strategy Training (SFA+MST) for People With Acquired Aphasia

Run by Teachers College, Columbia University · NCT07036406 · Data updated 2026-11-12

This trial will test whether adding metacognitive strategy training to semantic feature analysis helps adults with acquired aphasia name pictures more accurately and speak with more informative content.

Quick facts

PhasePhase 2
Study typeInterventional
Ages18 Years to 89 Years
SexAll
Enrollment40 (estimated)
SponsorTeachers College, Columbia University
Academic / other
Locations1 site (New York, New York)
StatusRecruiting
StartedJuly 28, 2025
Main results expectedDecember 2026
Study endsJuly 2027
Registry record updatedJune 25, 2026
Trial IDNCT07036406 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are English-speaking adults aged 18–89 who are at least six months post-onset from a single acute event (e.g., left-hemisphere stroke), with normal or corrected hearing and vision and no progressive neurological disease.

Probably not a fit

People with neurodegenerative disease, severe motor speech disorders, significant psychiatric or substance-abuse history, uncorrected hearing or vision problems, or those outside the 18–89 age range are unlikely to be eligible or to benefit from these specific interventions.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 2 interventional trial compares two two-month therapy protocols—traditional Semantic Feature Analysis (SFA) and SFA combined with Metacognitive Strategy Training (SFA+MST)—in adults with chronic acquired aphasia. Participants complete 5–7 pre-treatment assessment sessions of picture naming and spontaneous speech tasks, then receive one of the two treatments. Primary outcomes are picture naming accuracy, use of naming strategies during picture naming, percent of informative content, and rate of informative content during spontaneous speech. Investigators will compare group-level changes to determine whether adding metacognitive training yields larger effects and better generalization to everyday communication.

Why it matters

Potential benefit: If successful, adding metacognitive strategy training could produce larger gains in naming and more informative spontaneous speech for people with chronic aphasia.

How similar studies have gone: Traditional SFA has established evidence for improving naming, while combining SFA with metacognitive strategy training is a newer approach with limited but promising preliminary support.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Have aphasia due to a single acute event (e.g., left-hemisphere stroke, traumatic brain injury)
* Be at least six-months post aphasia-onset,
* Be a proficient English speaker,
* Have normal or corrected to normal hearing (i.e., hearing aids) and vision (i.e., eyeglasses),
* Have no history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug/alcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems

Exclusion Criteria:

* A history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug/alcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems,
* Children under the age of 18,
* Adults over the age of 89,
* Uncorrected hearing and vision.

Where it's running

  • Teachers College, Columbia University
    New York, New York, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.