Neural signals of getting speech back after stroke
Official title: Neural Correlates of Recovery from Aphasia After Stroke
Funded at Vanderbilt University Medical Center · NIH-11381219 · Data updated 2026-11-12
This grant studies how the brain changes as people recover speech after a stroke, to help predict and improve language recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | June 1, 2014 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $514,164 |
| NIH project number | 5R01DC013270-12 |
| Project ID | NIH-11381219 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with acute post-stroke aphasia who are enrolled within the first hours to days after a stroke and followed over time.
✕Less likely to help
Patients without aphasia or those not pursuing recovery-focused rehabilitation may not directly benefit.
What this research studies
The project follows people with aphasia after stroke to map how language improves over the first year. It uses brain imaging, language tests, and patient information to identify which factors help recovery. The researchers have already built a large dataset and plan to enroll 240 more participants over four years to expand understanding. The goal is to translate findings into better, more personalized care for people with aphasia.
Why it matters
Potential benefit: If successful, the work could lead to personalized therapies and better timing for language rehabilitation after stroke.
How similar studies have gone: Previous work has shown predictable patterns of aphasia recovery and the importance of specific brain regions; this renewal seeks to extend and translate those insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: De Riesthal, Michael R — Vanderbilt University Medical Center
- Study coordinator: De Riesthal, Michael R
Related research
Other NIH-funded projects on the same topics.
-
Neural signals linked to recovery from aphasia after stroke
This grant follows people who recently had a stroke and aphasia to understand why some recover language abilities better than others.
-
Computational modeling of language in bilingual adults after stroke and with neurodegenerative conditions
A computer-based study will model how bilingual Spanish-English speakers experience language changes after stroke and with neurodegenerative disorders, to inform better care for affected patients.
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Restoring speech with a brain implant for stroke-related aphasia
A study at UC Davis aims to help people who have language trouble after a stroke by using a tiny brain implant to turn brain signals into spoken words.
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Predicting language recovery after stroke using AI
A new AI-based project uses brain scans and personal data to forecast how aphasia may progress after a stroke, with the goal of guiding personalized treatment.
-
How the brain recovers language after a stroke
This research follows people with aphasia after stroke to find brain and behavior signs that predict who will regain speech and language.
-
Electrical Field Guided TMS and Constraint Induced Language Therapy for Subacute Post-Stroke Aphasia
This study tests a targeted brain stimulation plus speech therapy approach to help people with language loss after a recent stroke.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.