Aerobic exercise plus targeted speech exercises to improve reading after stroke

Improving Reading Competence in Aphasia with Combined Aerobic Exercise and Phono-Motor Treatment

NIH-funded research Kessler Foundation, INC. · NIH-11285474

Short bouts of aerobic exercise done before focused speech-based reading work may help people with post-stroke aphasia read more accurately and regain independence.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionKessler Foundation, INC. NIH-funded
Lab location1 site (East Hanover, UNITED STATES)
Project IDNIH-11285474 on NIH RePORTER

What this research studies

If you join, you would do a supervised bout of aerobic activity (like cycling or walking) immediately before intensive, therapist-guided phonological reading exercises. The team will track your reading skills over time and may measure brain blood flow and oxygenation to see whether exercise boosts the brain's response to therapy. The approach is based on the idea that exercise temporarily increases cerebral blood flow and makes the brain more ready to re-learn sound–letter connections. Sessions are delivered repeatedly over weeks to try to produce lasting improvements in reading.

Who could benefit from this research

Good fit: Adults with chronic post-stroke aphasia who have persistent reading difficulties and are medically cleared to perform moderate aerobic exercise are ideal candidates.

Not a fit: People who cannot safely perform aerobic exercise due to severe cardiac, respiratory, or mobility limitations, or those without phonological-based reading impairments, may not benefit from this combined approach.

Why it matters

Potential benefit: If successful, this approach could produce bigger and more lasting gains in reading ability for people with post-stroke aphasia, improving daily communication and independence.

How similar studies have performed: Early and pilot studies suggest aerobic exercise can increase brain blood flow and may enhance language therapy, but combining exercise specifically with phono-motor reading treatment is a newer approach.

Where this research is happening

East Hanover, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.