Exploring the effects of TMS on language processing in stroke and aphasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of Transcranial Magnetic Stimulation (TMS) on individuals who have experienced a stroke and suffer from aphasia, as well as healthy participants. It employs a randomized, within-subject design to assess the effects of TMS on semantic and phonological language processes, both in isolation and in interaction with other cognitive functions. The study aims to identify how TMS can influence language processing by targeting specific brain regions associated with these functions, based on prior neuroimaging and neuropsychological research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with left hemisphere stroke
* Consent date \>= 1 month after stroke onset
* Right-handed
* Fluent in English
* 18 years of age or older

Exclusion Criteria:

* Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
* Non-decisional per decisionality questionnaire or other clinical assessment
* Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)
* A chronic medical condition that is not treated or is unstable
* Presence of

  1. cardiac stimulators or pacemakers or intracardiac lines
  2. neurostimulators
  3. medication infusion device
  4. any other implants near the scalp (e.g., cochlear implants) or in the eye
  5. metal in the body
* Pregnancy
* History of skull fractures, or skin diseases
* History of ongoing or unmanaged seizures or a family history of epilepsy
* Presence of factors that potentially decrease seizure thresholds
* On pro-convulsant medications
* Untreated Sleep deprivation or insomnia
* Ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)
* History of dyslexia or other developmental learning disabilities

Where it's running

• Medical College of Wisconsin
  Milwaukee, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Priyanka Shah-Basak, PhD — Medical College of Wisconsin
• Study coordinator: Sidney Schoenrock
• Email: sschoenrock@mcw.edu
• Phone: 414-955-7579

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• TMS plus language therapy to improve word-finding after left-hemisphere stroke

  Researchers will try excitatory transcranial magnetic stimulation combined with semantic feature analysis language therapy to improve word-finding in adults with aphasia after left-hemisphere stroke.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT06974279

• Identifying brain recovery markers in stroke patients with aphasia

  This study is trying to find out how brain recovery affects language skills in stroke patients with aphasia to help improve their treatment and recovery.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06471127

• Tailoring rTMS for Post-Stroke Aphasia Based on Language Profile

  A non-drug brain stimulation approach is tested to see if customizing rTMS targets improves language recovery in people with aphasia after a left-brain stroke.

  Recruiting University of South Carolina · Columbia, South Carolina · NCT07608588

• tDCS in Rehab for Stroke-Related Aphasia: A Practical Implementation

  This study tests whether a 20-minute anodal tDCS session paired with speech therapy can be integrated into routine inpatient and outpatient rehab for people who recently had a stroke and now have aphasia.

  Recruiting Casa Colina Hospital and Centers for Healthcare · Pomona, California · NCT07535788

• Decoding Mandarin speech features from brain-surface signals

  This project will try to decode imagined Mandarin speech, including lexical tones, from high-density brain-surface (ECoG) signals in adult patients who are having clinically indicated cortical electrode placement.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07460037

• Digital speech-therapy app Zenicom for subacute post-stroke aphasia in Korean speakers

  This trial will try the Zenicom digital speech-therapy app alongside conventional therapy to see if it helps Korean adults with aphasia after a recent (within 3 months) stroke.

  Recruiting at 3 sites Phase 2 Seoul National University Bundang Hospital · Seongnam-si and 2 other locations · NCT07397923

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.