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Clinical trials and research at University of Texas Southwestern Medical Center

• 160Clinical trials
• 4Countries

Newest trials

All recruiting trials (newest 150 of 160)

• Tirzepatide for methamphetamine use disorder (phase 2)

  This phase 2 trial tests whether weekly tirzepatide injections can help adults with moderate to severe methamphetamine use disorder reduce use and improve outcomes compared with placebo.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Los Angeles, California and 3 other locations · NCT07825857

• Do beverage cues drive craving in adults with AUD

  In adults with alcohol use disorder, this study tests whether different non-alcoholic beverage cues can trigger cravings differently when people see and smell them without drinking.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07788716

• How foot braces might help people with ataxia walk better

  This study tests whether wearing foot orthoses at home can improve gait and balance for adults with cerebellar ataxia.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07720700

• Personalized Ultrafractionated Stereotactic Radiotherapy with Perioperative FLOT for GEJ and Esophageal Cancer

  This trial tests adding a personalized, ultra-fractionated radiotherapy boost (PULSAR) to standard perioperative FLOT chemotherapy for patients with esophageal or gastroesophageal junction cancer to see if it can be used safely.

  Recruiting Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07700420

• Hemophilia A: comparing long-acting FVIII replacement vs non-FVIII therapy in kids

  This study tests whether children with moderate to severe Hemophilia A on long-acting FVIII or non-FVIII therapies form clots differently and develop small joint bleeds or early joint changes.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07692217

• Adaptive dosing of immune therapy for hepatocellular carcinoma

  This trial tests whether changing the dosing schedule of nivolumab plus ipilimumab can help people with hepatocellular carcinoma who have Child-Pugh B liver disease.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07689175

• High-dose bilateral tDCS for older adults with late-life depression

  This study tests whether high-dose, bilateral transcranial direct current stimulation can help people aged 60 or older with late-life depression who are on stable antidepressants.

  Recruiting Phase 1/2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07657234

• FOCUS Bipolar: Families Opening Conversations for Understanding Signs

  This project tests a family-centered screening approach to help identify early signs of bipolar disorder in youth who have a parent with bipolar disorder.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07622927

• Return of Cardiovascular Information: How Details Help or Hinder Change

  This study tests whether presenting personal heart risk information in a detailed vs. a simpler format helps people in Dallas change their health habits.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07613853

• Vagus nerve gene therapy (scAAV9/JeT-GAN) for giant axonal neuropathy

  This Phase 1 test delivers a gene therapy (scAAV9/JeT-GAN) directly into the vagus nerve to see if it can help people with confirmed giant axonal neuropathy who previously received intrathecal AAV/GAN.

  Recruiting Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07543991

• Using an automated CSF drainage device to help people with suspected iNPH

  This study tests whether the Intellidrop automated CSF drainage system can safely manage small fluid removals in older adults with suspected iNPH who are being evaluated for shunt therapy.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07494812

• PrEP Linkage With Immediate Medications in the Emergency Department

  This study tests starting PrEP right in the Parkland Memorial Hospital ED and linking patients to ongoing PrEP care to see if it increases PrEP uptake in Dallas.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07462611

• THIO and Cadonilimab for Resectable Liver Cancer

  This early-phase trial tests whether cadonilimab alone, ateganosine alone, or both together can safely help patients with resectable hepatocellular carcinoma.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07446257

• Parent–Adolescent Relationships, Heart Rate Variability, and Emotional Regulation in Teens with Depression

  This study looks at whether teen sleep heart rate variability relates to emotional regulation and the quality of parent–teen relationships in adolescents with depression, using a Fitbit at night for a week.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07430774

• How reducing tremor affects stigma in people with essential tremor

  This study will see if lowering hand tremor with focused ultrasound thalamotomy reduces stigma-related distress and social problems in adults with essential tremor.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07430761

• Video-guided vs direct laryngoscopy for less invasive surfactant delivery in extremely preterm infants

  This trial tests whether using video laryngoscopy helps give surfactant on the first try more often than direct laryngoscopy in extremely preterm babies needing surfactant.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07426016

• How Acetadote might affect metabolism in newly diagnosed glioblastoma

  This early-phase trial tests whether Acetadote can change brain tumor metabolism in adults with a new glioblastoma diagnosis.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07387666

• Text reminders to help parents keep teens safe after a suicide-related ED visit

  This study tests whether sending parents text messages can help them reduce their teen’s access to lethal means and increase safety practices after a suicide-related emergency visit.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07383714

• Phosphate assessment in people with chronic kidney disease

  This study will test how increasing dietary phosphate over three weeks affects blood and urine markers in adults with and without stage 3–4 chronic kidney disease.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07368946

• Adrenalectomy versus semaglutide for metabolic health in mild autonomous cortisol secretion

  We are testing whether removing the adrenal gland or treating with semaglutide better improves insulin resistance and other metabolic measures in adults with mild autonomous cortisol secretion, and comparing semaglutide effects to matched adults without adrenal tumors.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07361874

• Ventilation Feedback in EMS Resuscitation (ventilation during CPR)

  This trial tests whether real-time visual feedback helps EMS rescuers deliver the right amount of air during CPR in simulated OHCA.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07352709

• Pediatric Epilepsy Brain Mapping and Memory Study

  This study tests how the pediatric brain supports memory and decision-making using intracranial electrodes in kids with drug-resistant epilepsy.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07350551

• Outcomes for children with obesity in the Get Up & Go healthy lifestyle program

  This project will try whether the Get Up & Go family healthy lifestyle program helps children ages 6–14 with BMI at or above the 85th percentile improve health and activity measures compared with a waitlisted group.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07342855

• PSA-response–based androgen deprivation and nodal coverage for early salvage radiotherapy (RANGER)

  This trial tests whether using early PSA response to decide who gets extra pelvic radiotherapy and a short course of hormone therapy can treat men with rising PSA after prostatectomy while sparing others from unnecessary treatment.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07313241

• Unlocking PrEP: Peer health coaches to expand PrEP access during re-entry

  This project will try adding peer health coaches at a Dallas re-entry program to increase PrEP awareness and uptake among people with a history of justice involvement.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07292792

• Deucravacitinib added to current PsA treatment for difficult-to-control disease

  This study tests whether adding deucravacitinib to a patient’s existing Psoriatic Arthritis treatment can improve symptoms and quality of life for adults with hard-to-control disease.

  Recruiting Phase 4 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07280702

• Tailored exercise training for adults with HFpEF

  This program will test remote, personalized exercise and lifestyle plans to see if they help adults with HFpEF or at risk of it improve how much they can exercise and their muscle health.

  Recruiting Phase 2/3 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07223242

• Venous Compression for Fontan Patients

  This study tests whether wearing lower-extremity compression garments can increase exercise stroke volume in people with Fontan circulation.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07220226

• TTR stabilizers and blood transthyretin amyloid aggregates in ATTR-CM patients

  This research will test whether TTR-stabilizing drugs like tafamidis or acoramidis lower blood levels of transthyretin amyloid aggregates over time in people with ATTR-CM.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07196839

• Maximizing laser therapy success for Port-Wine Birthmarks in kids

  This study tests different laser treatment sequences to see which approach clears Port-Wine Stains in children with fewer sessions and less need for anesthesia.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT07183644

• Teen Recovery: Inspiration, Support, and Empowerment program

  This pilot will test whether an online peer-led recovery and support program helps 15–18-year-olds recently discharged from psychiatric care reduce suicidal thoughts, depression, anxiety, and re-hospitalization.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07170657

• Personalized PULSAR radiotherapy for advanced small cell lung cancer and brain metastases

  This trial will try personalized PULSAR radiotherapy schedules to see if they are safe and helpful for adults with extensive-stage small cell lung cancer who need thoracic radiation and for adults with 1–5 brain metastases.

  Recruiting Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07139990

• DynamiCare-based program to support re-entry for stimulant users at risk for HIV

  This study tests whether adding the DynamiCare mobile app plus patient navigation helps people released from justice settings who use stimulants to start HIV care (ART/PrEP) and reduce stimulant use.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · New Haven, Connecticut and 1 other locations · NCT07136363

• Non-invasive intracranial pressure monitoring with a skull-mounted sensor

  Researchers will try a small skull-mounted sensor to see if it records intracranial pressure waveforms like invasive monitors in adults who are having craniotomy, lumbar puncture, or shunt adjustment procedures.

  Recruiting University of Texas Southwestern Medical Center · Coppell, Texas · NCT07113353

• Sickle Cell Kidney Sample Bank

  This project will collect blood and urine from adults with sickle cell disease or sickle cell trait to see if linked samples and medical records can help researchers learn how kidney disease starts and progresses.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT07064174

• Recovery Through Inspiration, Support, and Empowerment for Young Adults

  This pilot will try peer-led one-on-one and small-group recovery support for 18–27-year-olds recently discharged from acute psychiatric care to help reduce suicidal thoughts, depression, anxiety, and rehospitalizations.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07051200

• How a large simulated burn affects cooling down after exercise in hot conditions

  This project will test whether covering 60% of the body to simulate a burn makes healthy adults take longer to cool down after exercising in the heat.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07050264

• Using CYTALUX (pafolacianine) with a near-infrared camera to help find cancer during surgery

  This trial will test whether a single injection of CYTALUX (pafolacianine) helps surgeons see gastrointestinal, foregut, pancreatic, hepatobiliary, esophageal, and gynecologic cancers during surgery using a special near-infrared camera.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07039526

• Single polypill combining aspirin, a P2Y12 inhibitor, and a statin after acute coronary syndrome

  This trial tests whether giving adults who had an acute coronary syndrome a single combined pill with aspirin, a P2Y12 inhibitor, and a high-intensity statin helps them stick to their medicines and lowers complications after discharge.

  Recruiting at 4 sites Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas and 3 other locations · NCT07032389

• Triple HIV/HBV/HCV screening alert in primary care

  Doctors in primary care will test a new EMR alert that suggests screening for HIV, HBV, and HCV when ordering blood tests for adults.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07031219

• SalSA vs LISA: Surfactant Delivery in Preterm Infants

  This study tests whether giving surfactant through SALSA (a supraglottic airway) is safer and more effective than the LISA thin-catheter method in babies born at 29-36 weeks who need help breathing.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07030270

• How heat and humidity affect core temperature during work-rest cycles in burn survivors

  This project will test whether heat and humidity change core body temperature during repeated 30-minute exercise and rest cycles in adults who had major burns (≥20% body surface) and in non-burned controls.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06966336

• Cooling methods to lower heat stress in heart failure

  This trial will test whether increasing skin wetness or wearing a water-saturated T-shirt can slow the rise in core temperature and reduce heart stress during heat-wave conditions in people with congestive heart failure.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06961929

• D-mannose to prevent recurrent urinary tract infections in post-menopausal women.

  This trial will test whether taking 2 g of D-mannose daily prevents recurrent urinary tract infections in post‑menopausal women.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06940622

• Leg heating for pregnant women with overweight or obesity

  This trial will try repeated leg heating to improve blood vessel function and lower the risk of high blood pressure in pregnant women with overweight or obesity.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06932250

• 9-week dietitian-led program for adults with spinal cord injury to reduce body fat and insulin resistance

  This program will try a 9-week dietitian-led version of the Diabetes Prevention Program to see if it lowers body fat and insulin resistance in adults with chronic spinal cord injury.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06924177

• Evaluating a PrEP implementation strategy for incarcerated individuals

  This study is testing a new way to help people in jail get access to PrEP and learn about HIV prevention to see if it can improve their health outcomes.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06919419

• Daily nitrofurantoin versus bladder electrofulguration plus daily nitrofurantoin for women with recurrent UTIs

  This trial will test whether adding bladder electrofulguration to six months of daily nitrofurantoin helps women with recurrent cystitis have fewer infections than six months of nitrofurantoin alone.

  Recruiting Phase 1 University of Texas Southwestern Medical Center · Kansas City, Kansas and 1 other locations · NCT06907199

• Combining advanced MRI and PET imaging for heart disease prognosis

  This study is testing a new way of using advanced MRI and PET scans together to see if it can give better information about heart health for people with heart disease and those who are healthy.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06814587

• Investigating the effects of stellate ganglion block on retinal blood flow

  This study is testing if a special nerve block used for pain relief can improve blood flow in the eyes of patients with severe brain injuries.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06797752

• Combining Ligufalimab and Cadonilimab for Advanced Liver Cancers

  This study is testing if combining two treatments, Ligufalimab and Cadonilimab, can help people with advanced liver cancers that haven't improved with other therapies.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06789848

• Treatment for relapsed or refractory diffuse large B-cell lymphoma using IOMAB-ACT and CAR-T cell therapy

  This study is testing a new treatment combining a special radioactive drug and CAR-T cell therapy to see if it helps people with relapsed or hard-to-treat diffuse large B-cell lymphoma.

  Recruiting Phase 1/2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06768905

• mTOR medicines for healthier aging in older adults

  This trial will test two mTOR drugs, sirolimus and everolimus, in people 65 and older to measure drug levels and see if they improve biomarkers of aging.

  Recruiting Phase 1/2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06727305

• Personalized PULSAR MRI-guided radiation for central lung tumors

  This will test whether personalized, MRI-guided PULSAR radiation given as five widely spaced high-precision doses can safely treat small central primary or metastatic lung tumors.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06712745

• Deep brain stimulation for severe, treatment-resistant OCD

  This trial will try deep brain stimulation of the anteromedial subthalamic nucleus to see if it reduces symptoms in adults with severe, treatment-resistant OCD.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06660225

• Heart transplants from HIV-positive donors for HIV-positive recipients

  This study is testing if heart transplants from both HIV-positive and HIV-negative donors are safe and effective for people living with HIV.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06659952

• Effects of female hormones on spinal cord function

  This study is testing how changes in female hormones affect the spinal cord's ability to adapt and function in healthy young women and comparing it with men.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06656819

• Testing ION283 for Lafora Disease

  This study is testing a new treatment called ION283 to see if it is safe and effective for young people with Lafora Disease.

  Recruiting Phase 1/2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06609889

• Combining radiotherapy with checkpoint inhibition for metastatic kidney cancer

  This study is testing if combining a new type of radiotherapy with an injectable treatment can help patients with advanced kidney cancer whose disease has continued to progress after previous therapies.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06601296

• Heart failure prevention for patients with type 2 diabetes

  This study tests a new way to help people with type 2 diabetes avoid heart failure by using risk scores and alerts for their doctors to provide better care.

  Recruiting at 3 sites University of Texas Southwestern Medical Center · Dallas, Texas and 2 other locations · NCT06593327

• EchoGo-guided alerts to identify and prevent heart failure in people with type 2 diabetes

  This project will test if giving doctors EchoGo algorithm results and EHR alerts leads to more guideline-recommended heart-failure prevention treatment for people with type 2 diabetes who show signs of HFpEF on a recent echocardiogram.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06593314

• Effects of beta blockers on body temperature in older adults during heat exposure

  This study is testing how two common heart medications, propranolol and metoprolol, affect body temperature in older adults when they are exposed to extreme heat.

  Recruiting Phase 4 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06582680

• Using electrical stimulation to help stroke patients with leg movement

  This study tests if using electrical stimulation can help stroke patients improve their leg movement and mobility.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06541015

• Understanding action regulation in Parkinson's disease

  This study is trying to understand how people with Parkinson's disease can better control their movements when they are taking their medication.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06489483

• Understanding brain function and cognitive outcomes after traumatic brain injury

  This study is trying to see how blood flow and brain health after a serious head injury affect thinking and memory recovery one year later for those who have had a moderate to severe traumatic brain injury.

  Recruiting at 3 sites University of Texas Southwestern Medical Center · Dallas, Texas and 2 other locations · NCT06480838

• Comparing two types of radiation therapy for head and neck cancer

  This study is testing whether a new type of radiation therapy that focuses on specific cancerous areas can help people with head and neck cancer while causing fewer side effects than the standard treatment.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06477692

• Noninvasive ear-surface nerve stimulation for adults with traumatic brain injury in the ICU

  This pilot tests whether brief, noninvasive ear-surface nerve stimulation is safe and changes inflammation markers in adults with moderate-to-severe traumatic brain injury in the ICU.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT06467708

• Preoperative treatment for early-stage ER+ breast cancer using advanced imaging techniques

  This study is testing if a new way of using radiation therapy with advanced imaging can help people with early-stage ER+ breast cancer and see if it might replace the need for a certain type of surgery.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06444269

• Accelerated rTMS treatment for stimulant use disorder and depression

  This study is testing if a fast treatment using brain stimulation can help people with stimulant use disorder and depression feel better.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06424184

• Identifying metabolic features linked to melanoma spread

  This study is trying to see if the metabolic features of melanoma tumors can help predict how the cancer spreads and affects survival in patients undergoing surgery.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06400550

• Evaluating the effects of ravulizumab in patients with neuromyelitis optica spectrum disorder

  This study is testing if the medication ravulizumab can help people with neuromyelitis optica spectrum disorder feel better and improve their MRI results.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06398158

• Combining enfortumab vedotin with radiation for bladder cancer treatment

  This study is testing if combining a new drug called enfortumab vedotin with radiation can help patients with muscle invasive bladder cancer who can’t take standard chemotherapy before their surgery.

  Recruiting Phase 1/2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06394570

• Evaluating imaging performance of a new PET-CT system for prostate cancer

  This study is testing a new PET-CT imaging system to see if it works better than traditional scanners for men with prostate cancer.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06353321

• Home-based cardiac rehabilitation for people with heart failure

  This 12-week mobile app cardiac rehab program tests whether home-based rehab can improve outcomes for people with heart failure (EF ≥35%) who cannot attend center-based programs.

  Recruiting at 2 sites Phase 3 University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT06349941

• Deep phenotyping of Postural Orthostatic Tachycardia Syndrome

  This study is trying to better understand Postural Orthostatic Tachycardia Syndrome (POTS) by looking at different tests and samples from patients to improve diagnosis and treatment options.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06292104

• Cerebellar brain stimulation for women with anorexia nervosa

  This study is testing whether a type of brain stimulation can improve social skills and thinking flexibility in young women with anorexia nervosa.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06286930

• Combining Pembrolizumab and Lenvatinib for Cervical Cancer Treatment

  This study is testing if a combination of two drugs, pembrolizumab and lenvatinib, can help slow down tumor growth in people with advanced cervical cancer.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06266338

• Deep Brain Stimulation for treating severe schizophrenia

  This study is testing whether a new brain stimulation technique can help people with severe schizophrenia who haven't found relief from other treatments.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06257056

• Improving postpartum care access through telemedicine

  This study is testing two different ways to provide postpartum care—one with in-person education and virtual support, and the other through telehealth—to see which helps new mothers from underserved communities stay healthier after childbirth.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Atlanta, Georgia and 1 other locations · NCT06218355

• Escitalopram for adults with asthma and frequent exacerbations

  This trial will test whether the antidepressant escitalopram can reduce asthma flare-ups in adults with moderate-to-severe asthma who continue to have frequent exacerbations despite inhaled steroid and long-acting bronchodilator therapy.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06216535

• Comparing ultrasound and MRI for liver cancer detection

  This study is trying to see if a special ultrasound or a quicker MRI is better at finding early liver cancer in people with uncertain liver nodules.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Ann Arbor, Michigan and 1 other locations · NCT06184152

• Using intra-nasal ketorolac to relieve pain from ureteral stents after ureteroscopy

  This study is testing whether a nasal spray of ketorolac can help relieve pain better than oral diclofenac for patients with ureteral stents after surgery.

  Recruiting Phase 1/2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06158620

• Polypill to prevent heart failure in patients with diabetes

  This study tests if a combination pill can help people with type 2 diabetes who are at high risk for heart failure by improving their heart health and making it easier to stick to their medication.

  Recruiting Phase 1/2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06143566

• Using low dose colchicine to improve exercise capacity in heart failure patients with inflammation

  This study is testing if a low dose of colchicine can help people with heart failure feel better and exercise more easily.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06130059

• Non-invasive pain management after lumbar fusion surgery

  This study is testing if a new non-opioid pain relief method called transcutaneous auricular neurostimulation can help people feel less pain after lumbar fusion surgery.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06100172

• Comparing ultrasound and biomarker screening for liver cancer in patients with cirrhosis or hepatitis B

  This study is testing whether ultrasound or a blood test is better at finding liver cancer early in people with cirrhosis or chronic hepatitis B.

  Recruiting at 18 sites Phase 4 University of Texas Southwestern Medical Center · Los Angeles, California and 18 other locations · NCT06084234

• Comparing hypofractionated and conventional radiotherapy for laryngeal cancer

  This study is testing whether a new type of shorter radiation treatment is easier for people with laryngeal cancer to handle than the standard longer treatment.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06080503

• Using PET/MR to identify types of kidney tumors

  This study is testing if a new type of imaging can help doctors tell the difference between aggressive and harmless kidney tumors in people with certain kidney masses.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT06076538

• Evaluating heart tissue viability using advanced MRI techniques

  This study is testing a new MRI technique to see if it can help doctors find healthy heart tissue in patients with ischemic cardiomyopathy so they can better decide who needs heart surgery.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06047028

• Using PSMA PET imaging to guide targeted radiation therapy for high-risk prostate cancer

  This study tests if using PSMA PET imaging to time radiation therapy better can help improve treatment for people with high-risk prostate cancer.

  Recruiting Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT06044857

• Transcutaneous tibial nerve stimulation for urinary leakage in children with spina bifida

  This study will try mild electrical stimulation at the ankle (TTNS) to reduce urinary leakage in children aged 8–18 with spina bifida and neurogenic bladder.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06025734

• Using EGCG to prevent liver cancer in patients with cirrhosis

  This study is testing if a supplement called EGCG can help prevent liver cancer in people who have cirrhosis.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06015022

• Hydroxycitrate for preventing calcium phosphate kidney stones

  This study is testing if hydroxycitrate can help prevent calcium phosphate kidney stones from coming back in people who have had them before.

  Recruiting Phase 4 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06003348

• Using Segway for sensory training to improve motor and cognitive function in Parkinson's disease

  This study is testing if using a Segway for sensory training can help people with Parkinson's disease improve their balance and brain function.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05982730

• MindEx multifocal cognitive brain‑machine interface for people with severe paralysis

  This trial will test the MindEx system, which uses four tiny implanted brain chips to let people with severe paralysis control a computer or tablet with their thoughts.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05936619

• Higher dose of cabozantinib for advanced kidney cancer

  This study is testing whether a higher dose of cabozantinib can help people with advanced kidney cancer who didn’t respond to previous treatment with the same drug.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05931393

• Effect of repositioning and helmet therapy on infant head shape

  This study is testing if changing how caregivers position their babies and using special helmets can help improve head shape in infants with conditions like flat head syndrome.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05917678

• Optimizing oxygen levels for premature infants during resuscitation

  This study is testing which oxygen level is best for helping premature babies during resuscitation at birth to improve their chances of survival and long-term health.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05849077

• AI tool to predict treatment response in bladder cancer

  This study is testing a new AI tool that helps doctors predict how well bladder cancer patients will respond to certain treatments, so they can make better choices for those at risk of their cancer coming back.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT05825950

• Long-term treatment with Orlistat for high triglycerides in Type 1 Hyperlipoproteinemia

  This study is testing if the weight loss medication Orlistat can help people with Type 1 Hyperlipoproteinemia lower their high triglyceride levels safely over a long period.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05816343

• Improving breathing and exercise capacity in heart failure patients with obesity

  This study is testing if breathing a special helium-oxygen gas mixture can help people with heart failure and obesity breathe better and exercise more easily.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05723679

• Improving cholesterol treatment for blood donors with high cholesterol

  This study is testing a new way to help blood donors with high cholesterol manage their condition better than the usual care.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05693701

• Using brain stimulation to help children with autism

  This study is testing whether a type of brain stimulation can help children with autism improve their thinking skills and other challenges they face.

  Recruiting University of Texas Southwestern Medical Center · Dalls, Texas · NCT05691283

• Cryotherapy treatment for chronic cough

  This study tests if a freezing treatment for the throat can help people with a stubborn chronic cough that hasn't improved with other treatments.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05665244

• Screening for bladder cancer using urine tests

  This study is testing if regular urine tests every six months can help catch bladder cancer earlier in people over 50 who are at high risk.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05646485

• Investigating vocal fold hyperadduction and phonotrauma risk

  This study is trying to see if certain voice measurements can help identify the risk of vocal damage in people who use their voices in different ways.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05625191

• Effects of scopolamine on brain activity related to memory in epilepsy patients

  This study is testing if the drug scopolamine can change how well people with epilepsy remember things by looking at their brain activity while they do memory tasks.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05594017

• Evaluating a new imaging agent for detecting head and neck cancer

  This study is testing a new imaging agent to see if it can help doctors find head and neck cancers more easily during surgery, especially in patients with known or unknown cancer.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05576974

• Investigating early signs of heart disease in specific genetic carriers

  This study is trying to find early signs of heart disease in people with a specific genetic mutation linked to a heart condition called amyloidosis to help catch the disease sooner.

  Recruiting at 3 sites University of Texas Southwestern Medical Center · New York, New York and 2 other locations · NCT05489549

• Cooling methods to help elderly during heat waves

  This study is testing different cooling methods to see which one helps older adults stay safe and healthy during heat waves.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05484739

• Evaluating focal ablation treatments for prostate cancer

  This study is testing different types of heat and cold treatments for men with localized prostate cancer to see how well they work and how they affect quality of life.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05478694

• Exploring the link between mild cognitive impairment and mild traumatic brain injury

  This study is testing if a new brain stimulation treatment can improve memory in people with mild cognitive impairment who have also had a mild traumatic brain injury.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05446584

• Financial support program for cancer clinical trial participants

  This study is testing a financial support program for people in cancer clinical trials to see if it helps more patients join and improves their experiences.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05402033

• Registry of South Asians with Coronary Plaque Assessment

  This study is trying to understand why South Asians are at a higher risk for heart disease by looking at their coronary plaque and collecting health information from them and others.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05367297

• Comparing two mixtures of propofol and etomidate for anesthesia during endoscopic procedures

  This study is testing two different mixtures of anesthesia to see which one works better for keeping patients stable and minimizing side effects during endoscopic procedures.

  Recruiting Phase 3 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05358535

• Combining lenvatinib and pembrolizumab before surgery for advanced kidney cancer with IVC tumor thrombus

  This study is testing if combining two medications, lenvatinib and pembrolizumab, before surgery can help shrink advanced kidney cancer that has spread to a major vein and improve surgery results.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05319015

• Robotic nipple sparing mastectomy for breast cancer patients

  This study is testing if a robotic surgery method for nipple-sparing mastectomy can safely help breast cancer patients and those at high risk, while also checking how well it works compared to traditional surgery.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05245812

• Using Sirolimus to Prevent Functional Decline in Older Adults

  This study is testing if the drug sirolimus can help older adults aged 65 to 80 stay healthier and maintain their daily activities as they age.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05237687

• Evaluating home visits for managing chronic conditions like hypertension and diabetes

  This study is testing if home visits from doctors can help people with high blood pressure and diabetes manage their health better than regular clinic visits.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05168605

• Effects of dietary phosphate on exercise and body fat

  This study is testing if eating less phosphate can help healthy adults exercise better and manage their body fat more effectively.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05147909

• Testing Belantamab Mafodotin for AL Amyloidosis

  This study is testing a new drug called Belantamab Mafodotin to see if it can safely help people with relapsed or hard-to-treat AL Amyloidosis feel better.

  Recruiting at 2 sites Phase 1/2 University of Texas Southwestern Medical Center · Nashville, Tennessee and 2 other locations · NCT05145816

• Reducing blood pressure to prevent cognitive decline in older adults

  This study is testing if better blood pressure management can help older adults with high blood pressure avoid memory problems and dementia.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05106036

• Combination of immunotherapy and chemotherapy for HER2-negative breast cancer

  This study is testing if combining two immunotherapy drugs with standard chemotherapy can help people with advanced HER2-negative breast cancer feel better and live longer.

  Recruiting at 5 sites Phase 1 University of Texas Southwestern Medical Center · Chicago, Illinois and 6 other locations · NCT05029999

• Investigating how obesity affects lung function in older adults

  This study is testing how obesity affects breathing and exercise ability in older adults aged 65-75 to see if it causes more trouble with physical activity.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05028309

• Imaging study using [18F]PT2385 for renal cell carcinoma

  This study is testing a new imaging method using [18F]PT2385 to see if it can help understand tumor characteristics in people with renal cell carcinoma.

  Recruiting Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT04989959

• Understanding brain networks in movement disorders

  This study tests how deep brain stimulation and medication affect brain networks in people with Parkinson's disease and essential tremor to better understand their movement problems.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT04957095

• Comparing gemcitabine and water irrigation for bladder cancer recurrence prevention

  This study is testing whether using gemcitabine or sterile water after surgery can help prevent bladder cancer from coming back in patients who had their kidney and ureter removed.

  Recruiting Phase 3 University of Texas Southwestern Medical Center · Dallas, Texas · NCT04865939

• Understanding how the nervous system affects blood pressure in obesity-related hypertension

  This study is trying to see how the nervous system affects blood pressure during stress in people with obesity and high blood pressure.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT04838678

• Mobile app to manage swelling in kidney patients

  This study tests a mobile app that helps kidney patients manage swelling by adjusting their diuretic medication and tracking their daily health data.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT04759274

• Understanding how kidney tumors use nutrients for growth

  This study tests how kidney tumors use certain nutrients to grow by giving participants a special nutrient infusion during surgery and checking their blood and tissue samples.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT04623502

• Comparing therapies for infants with mild brain injury

  This study is testing whether cooling therapy can help infants with mild brain injury do better in their development compared to regular body temperature treatment.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT04621279

• Understanding immune responses in breast cancer treatment

  This study is testing if combining two cancer treatments can boost the immune system's ability to fight hormone receptor-positive breast cancer in patients who are eligible for surgery.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT04614194

• Evaluating clozapine's effectiveness in specific psychosis patients

  This study is testing if clozapine works better than risperidone for people with schizophrenia, schizoaffective disorder, and bipolar I disorder who have a specific brain activity pattern.

  Recruiting at 5 sites Phase 4 University of Texas Southwestern Medical Center · Hartford, Connecticut and 4 other locations · NCT04580134

• Using brain stimulation to help children with autism

  This study is testing if a type of brain stimulation can help children and young adults with autism feel better by reducing symptoms like repetitive behaviors and hyperactivity.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT04446442

• Evaluating lung therapies for patients after heart surgery

  This study tests three different breathing therapies to see which one helps patients recover their lung function best after heart surgery.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT04164173

• Deep brain stimulation for treatment-resistant depression using advanced imaging techniques

  This study is testing whether deep brain stimulation can help people with treatment-resistant depression by using advanced imaging to better target the areas of the brain involved in their symptoms.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03952962

• Investigating bone health in cystic fibrosis patients

  This study is testing how bone health is affected in people with cystic fibrosis and whether a medication called denosumab can help improve it.

  Recruiting Phase 4 University of Texas Southwestern Medical Center · Dallas, Texas · NCT03921060

• Using cognitive behavioral therapy to help parents of premature infants in the NICU

  This study is testing whether cognitive behavioral therapy can help parents of premature infants in the NICU feel less anxious and depressed, which may improve their relationship with their child and the child's development.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03906435

• Using neuroimaging to improve diagnosis and prognosis of Parkinson's disease and related conditions

  This study is trying to find brain imaging markers that can help doctors better diagnose and predict how Parkinson's disease and similar conditions will progress in patients.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03872102

• Imaging oxidative metabolism and neurotransmitter synthesis in the brain

  This project tests whether two types of hyperpolarized 13C‑pyruvate MRI scans can reliably measure brain energy use and neurotransmitter-related metabolism in healthy adults.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03849963

• Multidisciplinary care for patients with Multiple System Atrophy

  This study looks at how well specialized care helps people with Multiple System Atrophy feel and live better, while also checking how it affects their caregivers over five years.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03811808

• Using curcumin to prevent progression of low-risk prostate cancer

  This study is testing if curcumin, a natural supplement from turmeric, can help slow down low-risk prostate cancer in patients who are being closely monitored.

  Recruiting Phase 3 University of Texas Southwestern Medical Center · Dallas, Texas · NCT03769766

• Evaluating vitamin D's role in sarcoidosis

  This study is testing if giving vitamin D to people with sarcoidosis who have low levels of it can help reduce their symptoms compared to those who get a placebo.

  Recruiting Phase 4 University of Texas Southwestern Medical Center · Dallas, Texas · NCT03621553

• Evaluating outcomes of cancer and benign disease patients treated with radiation

  This study is trying to gather information from patients who have received radiation treatment for cancer or non-cancer conditions to see how well it worked and how it affected their quality of life.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03617237

• CT image analysis to predict biopsy results and outcomes in early lung cancer

  This project will test whether detailed features taken from screening CT scans can help predict which lung nodules are cancer on biopsy and how early-stage lung cancer patients will do.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03563976

• Investigating the relationship between genetic mutations and brain changes in dystonia

  This study is trying to see how genetic changes linked to dystonia affect the brain in people with the condition compared to healthy individuals.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03428009

• Assessing metabolic changes in brain tumors using advanced imaging techniques

  This study is testing a new imaging technique to see how brain tumors change metabolism in patients with different types of brain cancer.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03067467

• Improving hand control for amputees using advanced electrodes

  This study is testing if special electrodes can improve hand control for people with different types of upper limb amputations.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT02994160

• Collecting data on pupillometer assessments in neuro-intensive care

  This study is gathering information on how pupils react in critically ill patients to help doctors better understand and interpret these assessments in intensive care.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT02804438

• Identifying genetic and metabolic diseases in children

  This study is trying to find new genetic causes of rare diseases in children by looking closely at their genes and metabolism.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT02650622

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

Quick answers

How many clinical trials run by University of Texas Southwestern Medical Center are recruiting right now?

160, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (160 trials), Australia (1 trial), Canada (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 20, Phase 1/2: 8, Phase 4: 7, Phase 1: 7. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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