Effects of dietary phosphate on exercise and body fat

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how reducing dietary phosphate intake affects exercise capacity and fat distribution in healthy adults. Participants will undergo a randomized, crossover design where they will alternate between a high phosphate diet and a low phosphate diet over an 8-week period. The study will measure changes in skeletal muscle ATP synthesis and oxygen uptake during exercise testing, while also monitoring dietary phosphate intake through a dietary assessment tool. The goal is to determine if lowering phosphate intake can improve physical activity levels and metabolic health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

The randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise.

Exclusion Criteria:

1. history of cardiopulmonary disease or chronic kidney disease,
2. treatment with antihypertensive medications,
3. estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2, (4) diabetes mellitus or other systemic illness,

(5) pregnancy, (6) hypersensitivity to sodium phosphate, (7) any history of substance abuse or current cigarette use, (8) any history of psychiatric illness, (9) history of active malignancy, (10) serum phosphorus \< 2.4 or \> 4.5 mg/dL.

Where it's running

• University of Texas Southwestern
  Dallas, Texas, United States Recruiting

Study contacts

• Principal investigator: Wanpen Vongpatanasin, MD — Wanpen.Vongpatanasin@UTSouthwestern.edu
• Study coordinator: John Giacona, PA-C
• Email: john.giacona@utsouthwestern.edu
• Phone: 2146484403

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.