Effects of dietary phosphate on exercise and body fat
Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity
NA · University of Texas Southwestern Medical Center · NCT05147909
This study is testing if eating less phosphate can help healthy adults exercise better and manage their body fat more effectively.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 124 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center (other) |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT05147909 on ClinicalTrials.gov |
What this trial studies
This study investigates how reducing dietary phosphate intake affects exercise capacity and fat distribution in healthy adults. Participants will undergo a randomized, crossover design where they will alternate between a high phosphate diet and a low phosphate diet over an 8-week period. The study will measure changes in skeletal muscle ATP synthesis and oxygen uptake during exercise testing, while also monitoring dietary phosphate intake through a dietary assessment tool. The goal is to determine if lowering phosphate intake can improve physical activity levels and metabolic health.
Who should consider this trial
Good fit: Ideal candidates are otherwise healthy adults without chronic diseases or conditions that affect exercise capacity.
Not a fit: Patients with chronic kidney disease, diabetes, or cardiovascular diseases are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to dietary recommendations that enhance exercise capacity and reduce visceral fat in the general population.
How similar studies have performed: While studies in animal models have shown promising results, the relevance of these findings in humans remains largely untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: The randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise. Exclusion Criteria: 1. history of cardiopulmonary disease or chronic kidney disease, 2. treatment with antihypertensive medications, 3. estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2, (4) diabetes mellitus or other systemic illness, (5) pregnancy, (6) hypersensitivity to sodium phosphate, (7) any history of substance abuse or current cigarette use, (8) any history of psychiatric illness, (9) history of active malignancy, (10) serum phosphorus \< 2.4 or \> 4.5 mg/dL.
Where this trial is running
Dallas, Texas
- University of Texas Southwestern — Dallas, Texas, United States (RECRUITING)
Study contacts
- Principal investigator: Wanpen Vongpatanasin, MD — Wanpen.Vongpatanasin@UTSouthwestern.edu
- Study coordinator: John Giacona, PA-C
- Email: john.giacona@utsouthwestern.edu
- Phone: 2146484403
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Physical Inactivity, Phosphate Overload, Visceral Obesity