Investigating the effects of stellate ganglion block on retinal blood flow
Effect of the Stellate Ganglion Block on the Retinal Microcirculation: A Pilot Study
This study is testing if a special nerve block used for pain relief can improve blood flow in the eyes of patients with severe brain injuries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT06797752 on ClinicalTrials.gov |
What this trial studies
This observational study examines the impact of stellate ganglion nerve blocks on retinal microcirculation in patients with severe brain injuries, such as subarachnoid and intracerebral hemorrhages. The study aims to understand how this regional anesthesia technique, typically used for pain management, may influence cerebral sympathetic activity and potentially reduce vasospasm. Patients receiving the nerve block as part of their standard care will undergo OCTA scans to assess changes in their retinal microcirculation. The findings could provide insights into the broader implications of sympathetic nervous system modulation in critical neurological conditions.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are receiving stellate ganglion nerve blocks for approved indications.
Not a fit: Patients who are pregnant, non-English speaking, or have physical limitations preventing them from participating in the OCTA imaging will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with severe brain injuries by mitigating secondary brain damage.
How similar studies have performed: While the use of stellate ganglion blocks has shown promise in reducing sympathetic activity, this specific application in retinal microcirculation is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Patients receiving the stellate ganglion nerve block for an approved indication, e.g. complex regional pain syndrome Exclusion Criteria: * Pregnancy * Non-English speaking * Temporary or permanent physical limitation that renders the patient unable to sit up and look inside OCTA device
Where this trial is running
Dallas, Texas
- UT Southwestern Medical Center — Dallas, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Noah Jouett, DO, PhD — University of Texas Southwestern Medical Center
- Study coordinator: Noah Jouett, DO, PhD
- Email: noah.jouett@utsouthwestern.edu
- Phone: 214-645-7011
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.