Understanding action regulation in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the mechanisms of action regulation in patients with Parkinson's disease (PD) and how these can be improved through dopaminergic treatment. It focuses on the cognitive control aspects of behavior, particularly in relation to motor functions affected by PD. Participants will engage in behavioral experiments designed to assess their action regulation capabilities, specifically during 'on' periods when they respond positively to Levodopa medication. The study seeks to provide insights into the cognitive deficits associated with PD and their impact on daily life.

Why it matters

Who can join: the full rules

For Parkinson's Disease Patients:

Inclusion Criteria:

* Diagnosis of Parkinson's Disease by a movement disorder neurologist
* Levodopa responsive with clearly defined "on" periods, with at least 30% improvement in UPDRS III scores on vs off
* Willingness and ability to complete the behavioral experiments for up 3.5 hours
* No vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators

Exclusion Criteria:

* Patients with history of secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's Disease
* Patients with a disease or condition that prevents understanding or communication of informed consent, study demands, and testing protocol including cognitive decline, diagnosed forms of dementia, significant memory impairment (MoCA\<23), or hearing loss that prevents adequate communication with researcher

For Healthy subjects:

Inclusion Criteria:

* No history any diagnosed neurological disease(s), including movement disorders or cognitive decline
* No vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators

Where it's running

• University of Texas Southwestern Medical Center
  Dallas, Texas, United States Recruiting

Study contacts

• Study coordinator: Nader Pouratian, MD, Phd
• Email: nader.pouratian@utsouthwestern.edu
• Phone: (214) 645-5465

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.