Maximizing laser therapy success for Port-Wine Birthmarks in kids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares five laser treatment modalities for Port-Wine Birthmarks in pediatric participants, using up to two sessions and selecting the most effective modality for follow-up until clearance or a plateau is reached. If no further improvement is seen, a second round with all modalities helps identify differences in efficacy between treatments and between primary and refractory cases. Outcomes will be analyzed to determine which modality or sequence provides the best results and whether refractory cases benefit differently. The study is interventional and seeks to optimize treatment efficiency and safety in the pediatric population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of Port Wine Stain.
* Age Range: 2mo to 18 years of age.
* Stable PWS: The port wine stain should be stable, meaning there is no active inflammation or infection present, and it should not be changing in size or color due to factors like injury or disease.
* signed Consent: For ethical reasons, participants must be able to provide informed consent. In the case of minors, consent would generally be required from a parent or legal guardian.

General Health: Participants should generally be in good health, with no contraindications for laser therapy, such as certain skin conditions, infections, or hypersensitivity to light.

Exclusion Criteria:

* severe allergies to anesthesia
* active skin infections or inflammation
* recent laser therapy
* use of Photosensitizing medications
* participation in other laser studies

Where it's running

• Children's Medical Center
  Dallas, Texas, United States Recruiting
• Children's Medical Center
  Plano, Texas, United States Recruiting

Study contacts

• Principal investigator: James Seaward, MD — University of Texas Southwestern Medical Center
• Study coordinator: James R Seaward, MD
• Email: james.seaward@utsouthwestern.edu
• Phone: 214 456 5250

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• ADVATx laser treatment for port-wine stains (vascular birthmarks)

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• Treatment of port wine birthmarks with a laser

  This study is testing a laser treatment for port wine birthmarks to see which method works better and is easier for patients to handle.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05841628

• Evaluating Light Dose for Treating Port-Wine Birthmarks with Hemoporfin PDT

  This study is testing how well a new light treatment using Hemoporfin can help people with port-wine birthmarks on their face and neck.

  Recruiting at 5 sites Phase 2 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. · Irvine, California and 4 other locations · NCT05171894

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.