Exploring the link between mild cognitive impairment and mild traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether biological changes in individuals with amnestic mild cognitive impairment (aMCI) are associated with a history of mild traumatic brain injury (mTBI). Participants will undergo ten study visits, starting with a blood draw and memory evaluation, followed by randomization into one of three conditions of high definition transcranial direct current stimulation (HD-tDCS). Each participant will experience active or sham stimulation over three consecutive days, with memory assessments conducted after each condition. The study aims to understand the effects of HD-tDCS on memory in relation to mTBI history.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Active diagnosis of amnestic mild cognitive impairment
2. Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample
3. Female and male subjects
4. All races/ethnicities
5. Age 55 years and older
6. Fluent in English

Exclusion Criteria:

1. Mild traumatic brain injury within past year
2. Lifetime history of moderate or severe brain injury
3. Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor)
4. Lifetime major cardiovascular conditions (e.g., heart attack, heart failure)
5. Current substance use disorder
6. Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder)
7. Current vision or hearing impairment that interferes with testing
8. Any electronic and or metallic implants in the skull or brain
9. Current medication use known to alter HD-tDCS reactivity

Where it's running

• University of Texas Southwestern Medical Center
  Dallas, Texas, United States Recruiting

Study contacts

• Study coordinator: Hannah Cabrera, MCRC
• Email: Hannah.Cabrera@utsw.edu
• Phone: 214-865-9508

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.