Registry of South Asians with Coronary Plaque Assessment
South Asians and Coronary Plaque Registry
This study is trying to understand why South Asians are at a higher risk for heart disease by looking at their coronary plaque and collecting health information from them and others.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT05367297 on ClinicalTrials.gov |
What this trial studies
This registry aims to recruit South Asian individuals and non-South Asian controls to assess coronary plaque characteristics and understand the increased risk of coronary artery disease in South Asians. Participants will complete surveys on demographics and medical history, undergo blood collection, and have a coronary CT angiogram (CCTA) performed. The collected data will be combined with clinical information from electronic health records to generate insights and preliminary data for future studies focused on cardiovascular health in this high-risk population.
Who should consider this trial
Good fit: Ideal candidates include South Asian adults aged 18 and older who can self-identify their ethnicity and provide informed consent.
Not a fit: Patients under 18, those with impaired renal function, or individuals who cannot undergo CCTA will not benefit from this study.
Why it matters
Potential benefit: If successful, this registry could lead to improved understanding and management of coronary artery disease in South Asian individuals.
How similar studies have performed: While this approach is focused on a specific ethnic group, similar studies have shown success in understanding cardiovascular risks in diverse populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males and Females: Age 18 years or above * South Asian (SA) adults through self-identification (South Asians to have both biological parents with ancestry from India, Pakistan, Sri Lanka, Nepal and Bangladesh) * We also propose to enroll an equivalent number of individuals of other descent as a comparator group (Non SA Adult Volunteers) * Sampling Method: Probability Sample Exclusion Criteria: * Under the age of 18 years * Unable to give informed consent * Impaired renal function: estimated glomerular filtration rate ≤ 45ml/min * Baseline heart rate≥70 bpm or ≥66 bpm after beta blocker * Body mass index (BMI) of 35 or greater * Prior anaphylactic/non-anaphylactic reaction or other contraindication to iodinated contrast * Anyone who cannot do CCTA for any reason * Pregnancy
Where this trial is running
Dallas, Texas
- University of Texas Southwestern Medical Center — Dallas, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Anand Rohatgi, MD — University of Texas Southwestern Medical Center
- Study coordinator: Destiny Jones
- Email: SAHealth@UTSouthwestern.edu
- Phone: 214.645.2049
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.