Investigating vocal fold hyperadduction and phonotrauma risk

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify objective measures associated with hyperadduction of the vocal folds to better understand the risk of developing phonotrauma. It will analyze changes in cepstral peak prominence (CPP) and the difference between the first two harmonics of the voice spectrum (H1-H2) in response to different phonation patterns. The study will involve two main aims: first, to assess how CPP and H1-H2 vary with pressed voice production in individuals without laryngeal pathology, and second, to evaluate the sensitivity and responsiveness of these measures to detect changes in voice production conditions.

Why it matters

Who can join: the full rules

Control Group:

Inclusion Criteria:

1. 18-65 years of age (to avoid confounding physiological factors related to puberty or presbyphonia)
2. No history of or current voice disorder
3. Auditory perceptual presentation globally within functional limits (as determined by a voice specialized SLP).

Exclusion Criteria:

1. Atypical auditory-perceptual voice presentation
2. History of voice disorder or laryngeal surgery.

Patient Group:

Inclusion Criteria:

1. Diagnosed with phonotrauma (i.e., vocal fold nodules, vocal fold polyp, vocal fold pseudocyst, mid-fold edema) by a laryngologist.
2. 18-65 years of age

Exclusion Criteria:

1. Diagnosis of voice disorder not related to phonotrauma (e.g., vocal fold immobility, laryngeal dystonia, primary muscle tension dysphonia, etc.)
2. Previous history of laryngeal surgery or voice therapy (to avoid confounding effects of previous treatment).

Where it's running

• UT Southwestern Medical Center
  Dallas, Texas, United States Recruiting

Study contacts

• Study coordinator: Laura Toles, PhD
• Email: Laura.Toles@UTSouthwestern.edu
• Phone: 214-645-2943

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.