How a large simulated burn affects cooling down after exercise in hot conditions
Official title: The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments
Run by University of Texas Southwestern Medical Center · NCT07050264 · Data updated 2026-11-12
This project will test whether covering 60% of the body to simulate a burn makes healthy adults take longer to cool down after exercising in the heat.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 28 (estimated) |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | August 1, 2028 |
| Study ends | August 1, 2028 |
| Registry record updated | May 26, 2026 |
| Trial ID | NCT07050264 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults 18–65 years old without major chronic illnesses, not pregnant, nonsmokers, with BMI under 31 kg/m2 and not taking medications that affect heat regulation.
✕Probably not a fit
People with cardiovascular disease, diabetes, neurological disorders, recent smokers, pregnant or breastfeeding individuals, those on thermoregulatory medications, or with BMI ≥ 31 kg/m2 are excluded and would not be expected to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Healthy adults aged 18–65 will perform a bout of exercise in a hot environment while investigators apply an absorbent, impermeable material over 60% of the body to simulate a burn injury. Core body temperature and other thermoregulatory markers will be measured during and after exercise to determine the rate of temperature recovery. The protocol compares post-exercise cooling with the simulated burn condition to previously observed responses in non-burned conditions. Participants with major medical problems, pregnancy, recent smoking history, certain medications, or BMI ≥ 31 kg/m2 are excluded to isolate the thermoregulatory effect of the simulated injury.
Why it matters
Potential benefit: If successful, the results could improve guidance on safe activity and cooling strategies for burn survivors and people with large-area skin grafts in hot environments.
How similar studies have gone: Previous work has shown that real and simulated large-area burns impair heat loss and lead to higher core temperatures during exercise, but post-exercise recovery rates have not been clearly defined.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 and 65 years of age * free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Exclusion Criteria: * Known heart disease * other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc. as well as serious abnormalities detected on routine screening. * Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test. * Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response. * Current smokers, as well as individuals who regularly smoked within the past 3 years. * body mass index is ≥ 31 kg/m2.
Where it's running
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Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States Recruiting
Study contacts
- Principal investigator: Craig G Crandall, PhD — University of Texas Southwestern Medical Center
- Study coordinator: Erin M Harper, B.S.
- Email: erin.harper2@utsouthwestern.edu
- Phone: 12143454737
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.