Pediatric Epilepsy Brain Mapping and Memory Study
Official title: Pediatric Epilepsy
Run by University of Texas Southwestern Medical Center · NCT07350551 · Data updated 2026-11-12
This study tests how the pediatric brain supports memory and decision-making using intracranial electrodes in kids with drug-resistant epilepsy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 3 Years to 25 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | December 2031 |
| Study ends | December 2032 |
| Registry record updated | October 6, 2026 |
| Trial ID | NCT07350551 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pediatric patients with drug-intractable epilepsy undergoing invasive monitoring in an epilepsy monitoring unit who can participate in pre-operative cognitive tasks.
✕Probably not a fit
Patients who do not undergo epilepsy surgery planning or who cannot complete the behavioral tasks may not benefit from the study insights.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This investigation uses intracranial EEG and functional brain mapping to explore how memory encoding and retrieval relate to brain activity. It involves pediatric patients undergoing invasive monitoring as part of epilepsy care, with recordings from subdural and depth electrodes during cognitive tasks. The goal is to better understand brain networks involved in learning and memory and to reduce cognitive risks during epilepsy surgery by informing safer resections. Findings may also illuminate mechanisms of cognitive deficits and guide future therapies for seizure disorders. Electrical stimulation and electrophysiology systems are used to collect and analyze data during the protocol.
Why it matters
Potential benefit: If successful, findings could lead to improved surgical planning and cognitive outcomes for children with epilepsy by preserving critical memory and decision-making regions.
How similar studies have gone: Prior research using intracranial recordings has yielded meaningful insights into memory networks, though pediatric-specific data in this context remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Candidates will be those who are admitted to the Epilepsy Monitoring Unit and are able to participate in a pre-operative evaluation using depth intracranial electrodes. The candidacy is determined independently by the patient's treating physician as part of the patient's routine medical care. * Patients have drug-intractable epilepsy undergoing invasive monitoring in the EMU. Exclusion Criteria: * Determination by clinicians and investigators that a patient is unable to complete the behavioral tasks required for the protocol due to either cognitive limits, psychological limits, or pain.
Where it's running
-
Children's Medical Center Dallas
Dallas, Texas, United States Recruiting
Study contacts
- Principal investigator: Angela V Price, M.D. — UT Southwestern
- Study coordinator: Tashinga Mupambo
- Email: Tashinga.Mupambo@UTSouthwestern.edu
- Phone: 214-645-1355
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Spatial scene memory testing for people with temporal lobe epilepsy having surgery
This project tests whether a virtual tour memory task combined with brain recordings can show how adults with temporal lobe epilepsy recognize and recall places.
-
Sleep-friendly Seizure Risk with Wearable EEGs
This study tests whether a wearable EEG headband can help predict seizure risk related to sleep in adults with epilepsy whose seizures are not well controlled.
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Understanding how the brain processes spatial information in epilepsy patients
This study is testing how the brains of epilepsy patients process spatial information to better understand navigation problems they might face.
-
Mapping Epileptic Networks with MRI and iEEG
This study is testing a new way to use MRI and brain wave recordings to help people with hard-to-treat epilepsy understand their seizures better and improve their chances of successful surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.