Comparing two mixtures of propofol and etomidate for anesthesia during endoscopic procedures
Official title: Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)
Run by University of Texas Southwestern Medical Center · NCT05358535 · Data updated 2026-11-12
This study is testing two different mixtures of anesthesia to see which one works better for keeping patients stable and minimizing side effects during endoscopic procedures.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Status | Recruiting |
| Started | September 19, 2022 |
| Main results expected | January 2027 |
| Study ends | March 2027 |
| Registry record updated | January 20, 2026 |
| Trial ID | NCT05358535 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adult patients aged 18 and older who are scheduled for an endoscopic procedure at Clements University Hospital and have an ASA classification of 3 or above.
✕Probably not a fit
Patients with known allergies to the study drugs, those who refuse participation, or individuals with cognitive impairments that prevent informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the hemodynamic stability and adverse event profiles of two different admixtures of propofol and etomidate for anesthesia during endoscopic procedures. The study compares a 25% propofol and 75% etomidate mixture (P2E7) against a 75% propofol and 25% etomidate mixture (P7E2) in a randomized controlled double-blind design. It aims to provide insights into which admixture ratio is more effective in minimizing side effects and ensuring stable hemodynamics in patients with compromised cardiopulmonary status. The trial is conducted at the Clements University Hospital endoscopy lab, focusing on adult patients undergoing gastrointestinal endoscopy.
Why it matters
Potential benefit: If successful, this study could lead to safer anesthesia practices for patients undergoing endoscopic procedures, particularly those with compromised health.
How similar studies have gone: While there is limited definitive literature on the optimal admixture ratios of propofol and etomidate, this study aims to fill a gap in understanding and may build on previous findings in anesthesia practices.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adult patients (age ≥18 years old) 2. Having endoscopic procedure at CUH with anesthesia 3. ASA 3 or above 4. Ejection Fraction test result available Exclusion Criteria: 1. Known allergies or adverse reactions to study drugs or study drug components or preservatives 2. Patient refusal 3. Clinician refusal 4. Documented cognitive impairments precluding subject ability to consent for themselves unless a surrogate documented legally acceptable decision maker consents for patient participation 5. Prisoner or incarcerated or patients held by law enforcement officials in custody 6. Pregnancy or patient refusal for pregnancy testing or screening (standard UTSW policy and protocol requires pregnancy testing for appropriate patients prior to anesthesia)
Where it's running
-
Clements University Hospital
Dallas, Texas, United States Recruiting
Study contacts
- Study coordinator: Christopher Choi
- Email: christopher.choi@utsouthwestern.edu
- Phone: 2146486400
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.