Hydroxycitrate for preventing calcium phosphate kidney stones

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of hydroxycitrate, a compound similar to citrate, in reducing the recurrence of calcium phosphate kidney stones. It employs a double-blind, placebo-controlled, randomized, crossover design, where participants will experience four different treatment phases: placebo, low-dose hydroxycitrate, standard-dose hydroxycitrate, and potassium citrate. Each phase lasts one week, with a washout period in between, and participants will follow a controlled metabolic diet to ensure consistent dietary intake. Urine and blood samples will be collected to analyze the biochemical effects of the treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Calcium Phosphate stone formers

Exclusion Criteria:

* History of recurrent urinary tract infections
* Chronic diarrhea
* Estimated Glomerular Filtration Rate (eGFR) \< 45 ml/min/1.73 m2
* History of primary hyperparathyroidism
* Hypokalemia
* Hyperkalemia
* Pregnancy

Where it's running

• UT Southwestern Medical Center
  Dallas, Texas, United States Recruiting

Study contacts

• Principal investigator: Naim M Maalouf — University of Texas Southwestern Medical Center
• Study coordinator: Naim M Maalouf, Md
• Email: naim.maalouf@utsouthwestern.edu
• Phone: 214/648-2954

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.