Investigating bone health in cystic fibrosis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study involves up to 100 participants, including both cystic fibrosis (CF) patients and non-CF volunteers, who will undergo a single visit for assessments including DEXA scans, micro CT imaging, and blood collection to evaluate bone health. Additionally, a sub-study will treat approximately 10 adult CF patients with denosumab, a medication for osteoporosis, for up to 5 years, with annual follow-up visits for repeat assessments. The goal is to understand the markers of osteoporosis in CF and the effects of denosumab on bone health.

Why it matters

Who can join: the full rules

Cystic Fibrosis Main Study Inclusion Criteria:

* Must have CF diagnosis confirmed by sweat test or genotype analysis
* Subjects (and parents/legal guardians as applicable) must have the ability to read and write in English

Sub-study Exclusion Criteria:

* No CF diagnosis
* Men or women without osteoporosis
* Less than 18 years of age
* Unwilling to return annually for study visits for up to 5 years
* Unwilling and/or medically unable to take denosumab

Where it's running

• UT Southwestern Medical Center
  Dallas, Texas, United States Recruiting

Study contacts

• Study coordinator: Ashley Keller
• Email: ashley.keller@utsouthwestern.edu
• Phone: 2146482817

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.