Cryotherapy treatment for chronic cough

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety and efficacy of laryngeal cryotherapy for patients suffering from refractory neurogenic cough, a chronic condition characterized by persistent coughing. Participants will undergo a laryngoscopy to identify hypersensitive areas in the throat, followed by the cryotherapy procedure to numb overactive sensory nerves. The study will track patient outcomes through validated cough surveys and standard follow-up visits to assess symptom improvement. The approach aims to provide a new therapeutic option for individuals who have not responded to conventional treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients 18 years or older with diagnosis of neurogenic cough
* Neurogenic cough is a diagnosis of exclusion applied to persistent cough (8 weeks or longer)
* Negative workup for other causes, including sinonasal allergies/chronic sinusitis, cough-variant asthma, and GERD
* Patient willing to participate in a clinical trial

Exclusion Criteria:

* Uncontrolled reflux (scoring on Reflux Symptom index of 13 or higher)
* Vocal fold abnormalities or impairment
* History of asthma or other underlying lung condition not adequately treated or controlled
* Uncontrolled Allergic Rhinitis (Total Nasal Symptom Score \>6, which would indicate moderate disease32)
* Reported symptom of postnasal drip
* Current smoker
* Current neuromodulator medication use
* Patient unwilling to participate in clinical trial or sign an informed consent
* End stage medical disease with poor life expectancy
* Medical instability deemed by the investigators as a contraindication for enrollment
* Abnormal Chest X-ray
* Abnormal pulmonary function testing (PFTs)
* Positive local allergy panel (combined RAST testing)

Where it's running

• UT Southwestern Medical Center
  Dallas, Texas, United States Recruiting

Study contacts

• Principal investigator: Shumon Dhar, MD — University of Texas Southwestern Medical Center
• Study coordinator: Shumon Dhar, MD
• Email: Shumon.Dhar@UTSouthwestern.edu
• Phone: 214-645-7034

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.