Sponsor or institution
Clinical trials and research at Boston Children's Hospital
As of November 12, 2026, Find a Trial lists 104 clinical trials run by Boston Children's Hospital that are recruiting, at sites in 6 countries (most in United States (103), Canada (3), Spain (2)). By phase: Phase 1/2 (6), Phase 4 (4), Phase 1 (4), Phase 2 (2). There are also 858 NIH-funded research projects at this institution, with $541.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 104Clinical trials
- 858NIH research projects
- 6Countries
Newest trials
All recruiting trials (104)
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Outcomes of tone-management surgery in children with spastic/dystonic quadriplegia
This study tests how well intrathecal baclofen pumps and dorsal/ventral rhizotomy help improve movement, comfort, and daily life for kids with severe CP and high muscle tone.
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Hematopoietic stem cell editing to treat sickle cell disease
This study tests whether a patient’s own blood stem cells can be edited to remove the sickle cell triggering gene and then returned to the patient.
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Wireless ultrasound monitor for fetal health in a single pregnancy
A single-center study will test a wireless adhesive ultrasound device on pregnant people with a singleton pregnancy to see if it can be worn comfortably and reliably for 10–30 minutes while collecting fetal and uterine data.
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Monitoring leg pressure in teens with tibia fractures
A sensor is placed during surgery to see if measuring anterior leg pressure can help doctors spot acute compartment syndrome in teens with tibia fractures.
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Indocyanine green for diagnosing biliary atresia
This test tries to see if a harmless fluorescent dye (indocyanine green) can show whether infants under 3 months with cholestasis have blocked bile ducts (biliary atresia).
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Fetal embolization for vein of Galen malformation in late gestation
This study tests a one-time fetal embolization procedure for babies with vein of Galen malformations when the fetus is at least 34 weeks along.
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CRUSH curriculum for romance and sexual health for autistic young adults
This project will try the CRUSH program—a group course plus one-to-one coaching—to teach sexual health and dating skills to autistic adults ages 18 to 30.
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Virtual Reality and Biofeedback for Adolescents with Chronic Dizziness
This study tests a virtual reality and biofeedback approach to help adolescents with chronic dizziness from PPPD or vestibular migraine see if it can reduce symptoms and improve daily function.
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Propofol-only vs dexmedetomidine-propofol for sedation in children undergoing MRI
This study tests whether using dexmedetomidine with propofol works better or differently than propofol alone for sedating kids during MRI.
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High bile-binding foods to reduce bile acids in the upper digestive tract
This test will see if different gastrostomy tube feeds—a standard amino acid formula, a low bile‑binding blended feed, or a high bile‑binding blended feed—lower bile acid levels in the stomach and saliva of people who get most of their nutrition through a gastrostomy.
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Treatment comparison for Hoffa's fat pad impingement in teenage female athletes
This will test whether an ultrasound-guided corticosteroid injection plus physical therapy helps teenage female athletes with Hoffa's fat pad impingement more than a saline injection plus physical therapy.
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Valproate to Help Residual Amblyopia in Kids 8-17
This trial tests whether adding valproate to standard patching can improve vision in children and teens with residual amblyopia beyond the normal treatment window.
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Precision genetic therapy for Ataxia-Telangiectasia using ATM-targeted ASO
This trial tests a targeted genetic therapy called atipeksen to see if it is safe and helps slow neurologic decline in people with Ataxia-Telangiectasia who carry a specific ATM gene mutation.
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Microvascular circulation in kids after heart surgery
This study tests whether a handheld microcirculation camera can reveal microvascular status in children after heart surgery with Tetralogy of Fallot or VSD repair.
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Genetic causes of neonatal encephalopathy and related conditions
This project will see if DNA changes help explain neonatal encephalopathy in children under 6 who receive care at Boston Children's Hospital.
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Balloon inflation time for esophageal narrowing after atresia repair
This trial will try different balloon inflation times during endoscopic dilation to see which works best for children with narrowing after esophageal atresia repair.
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Striae Distensae Treatment with a Skin Abrasion Device
A device that abrades the skin under local anesthesia is tested to see if it can improve the appearance of stretch marks (striae distensae) and whether it is safe for patients.
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Breaking Silence Through Story: guided journaling for parents of children with urogenital conditions
This program tests whether guided journaling can lower stress and anxiety for parents of children with urogenital conditions such as differences of sex development or hypospadias.
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Registry and natural history of epilepsy-dyskinesia syndromes
This registry will collect health data and biological samples from people of all ages who have a genetic diagnosis of epilepsy-dyskinesia syndromes to see how their genes relate to their movement and seizure symptoms over time.
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Oral saliva testing to detect recent cannabis use in young adults.
This project will test whether at-home saliva tests can detect recent cannabis use in 18-to-30-year-olds who use cannabis at least once a week.
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Nucleoside treatment for telomere biology disorders
This will try whether taking two oral nucleosides (deoxycytidine and deoxythymidine) for 24 weeks is safe and may change blood, bone marrow, or lung problems in people aged 1–70 with telomere biology disorders.
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Treatment with CAR T cells for high-risk neuroblastoma in children
This study is testing a new CAR T cell treatment for children with hard-to-treat neuroblastoma to see if it is safe and how well it works.
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Predicting blood needs and hemolysis risk in children having heart surgery
This project will collect blood samples from children having heart surgery to try to build a mathematical model that predicts transfusion needs and hemolysis risk during surgery.
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Exploring genetic causes of infantile epilepsies and their effects
This study is trying to find new genetic causes of infantile epilepsies in babies to see how these discoveries can help improve care for them and their families.
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Restarting triple modulator therapy with close safety monitoring
This project tests whether people with cystic fibrosis aged 6 and up who stopped or changed elexacaftor/tezacaftor/ivacaftor (ETI) because of mental health or liver problems can start vanzacaftor/tezacaftor/deutivacaftor (VTD) safely with close monitoring.
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Normal intestinal development and disease in premature and full-term newborns
This project will collect intestinal tissue from newborns and infants up to age 2 who have GI surgery or biopsies to see how the human intestine develops and how conditions like NEC affect it.
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Gene editing of your own blood stem cells to boost fetal hemoglobin for severe sickle cell disease and beta-thalassemia
This trial will test whether editing a specific gene in patients' own blood stem cells can raise fetal hemoglobin and reduce symptoms in people aged 13–40 with severe sickle cell disease or transfusion-dependent beta-thalassemia.
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Bedtime Stories: tailored sleep-health messages for caregivers of school-aged children
This program tests whether mobile, tailored sleep-health messages help caregivers of 5–11 year-old children from low-income or historically marginalized Boston communities improve children's sleep routines and behaviors.
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Registry for Progressive Myoclonus Epilepsy Type 1
This study is trying to gather information and samples from people with Progressive Myoclonus Epilepsy Type 1 to better understand the disease and help develop future treatments.
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Registry for pediatric deep brain stimulation outcomes
This study is creating a database to collect information on how deep brain stimulation helps children with movement disorders like dystonia and Tourette syndrome, to see how safe and effective the treatment is.
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Understanding epilepsy-dyskinesia syndromes in children
This study is trying to learn more about epilepsy-dyskinesia syndromes in children by gathering information from different countries to see how these movement and seizure disorders are related.
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Resilience support for adolescents and young adults with sickle cell disease
This project will test a resilience-building program (PRISM) delivered through a collaborative care model for adolescents and young adults with sickle cell disease to see if it is feasible and acceptable.
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Research network for hereditary spastic paraplegia and primary lateral sclerosis
This study is trying to learn more about hereditary spastic paraplegia and primary lateral sclerosis by enrolling people with specific types of the condition to help find better treatments and understand how these diseases progress.
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Liposomal bupivacaine versus standard bupivacaine with epinephrine for pain after adolescent spinal fusion
This trial tests whether injecting liposomal bupivacaine instead of 0.25% bupivacaine with epinephrine during posterior spinal fusion reduces opioid use after surgery in adolescents aged 10 to 17 with idiopathic scoliosis.
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Profiling micro RNA in newborns with congenital heart disease
This study is trying to understand how certain molecules in the blood of newborns with severe congenital heart disease affect their risk of blood clots during surgery.
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Transplanting heart valves from donors into patients who need them
This study is testing if heart valves from donors can help kids and young adults who need valve replacements by providing a solution that grows with them and reduces the need for more surgeries later on.
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Nutritional education program for children with celiac disease
This study is testing a nutrition program for kids with celiac disease to see if teaching them about healthy, gluten-free foods can improve their health and reduce risks from certain gluten-free products.
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Examining opioid use in adolescents after surgery
This study looks at how surgery-related opioid use affects teenagers aged 12-17 and aims to find out what factors might lead to opioid use disorder after their surgery.
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Comparing language used during anesthesia induction in children
This study tests whether using positive language instead of standard language during anesthesia can help reduce anxiety and negative behaviors in children aged 5 to 10 years.
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TransHealthGUIDE: Digital support for gender-diverse young adults and their caregivers
This trial tests an interactive educational app to support transgender and gender-diverse young adults ages 18-29 and their caregivers and see if using it improves mental health outcomes.
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Registry for Shwachman-Diamond Syndrome and related conditions
This study is collecting health information and samples from people with Shwachman-Diamond Syndrome to learn more about the condition and improve treatment options.
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Evaluating new fetoscopes for in-utero surgery
This study is testing two new types of fetoscopes to see which one works better for performing safe surgeries on unborn babies with certain health issues.
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Effects of a ketogenic diet on type 1 diabetes in children
This study is testing if a ketogenic diet can help young children with newly diagnosed type 1 diabetes manage their condition better and stay healthy for longer.
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Postpyloric feedings to improve lung health in preterm infants
This study is testing if feeding preterm infants directly into their intestines can help improve their lung health better than regular feeding through the nose.
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Oral Microbiota Transplantation for Peanut Allergy Treatment
This study is testing if a new treatment using gut bacteria can help teenagers with peanut allergies tolerate peanuts better.
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Using a bedside decision-support tool to shorten ventilator time after pediatric heart surgery
This test will see if a computer decision-support tool can help clinicians shorten the time children under 12 spend on a ventilator after congenital heart surgery.
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Assessing gastric volume and emptying in pediatric surgery patients
This study tests if using ultrasound to measure stomach size and how quickly it empties is reliable for kids having surgery, compared to a standard test, to help keep them safe during anesthesia.
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Testing inhaled hydrogen gas for cardiac arrest treatment
This study is testing if breathing in hydrogen gas can help improve recovery for patients who have had a cardiac arrest and are receiving special life-saving treatment.
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Understanding Chopra-Amiel-Gordon Syndrome and its effects
This study is creating a registry to learn more about Chopra-Amiel-Gordon Syndrome by gathering information on symptoms, brain scans, and learning challenges from people with the condition.
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Effects of whole vs. nonfat milk on children's body composition
This study is testing whether kids aged 9 to 12 who drink whole milk instead of nonfat milk gain less weight and eat healthier foods.
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Esophagus and stomach movement problems and aspiration risk in children with neurologic impairment
This trial will test prucalopride versus famotidine to see which better reduces coughing, choking, and other aspiration-associated symptoms in tube-fed children ages 5–21 with neurologic impairment.
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Comparing thick and mildly thick blenderized tube feeds for children
This study is testing whether thicker or mildly thick blenderized tube feeds work better for kids with G-tubes who have stomach issues.
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Improving hospital safety by involving patients and families in reporting errors
This study is testing a new way to make hospitals safer by getting patients and their families involved in reporting mistakes and safety issues.
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Genetic analysis of hereditary spastic paraplegia
This study is trying to find out the genetic causes of hereditary spastic paraplegia to help improve diagnosis and treatment for people living with this condition.
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Improving discharge care for preterm infants with lung disease
This study is testing a new care plan for preterm infants with lung disease to see if it helps them transition better from the hospital to home and improves their health and parents' satisfaction.
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How transcatheter pulmonary valves interact with electrical pathways in repaired Tetralogy of Fallot
This project will test if detailed right-ventricular electrical mapping before transcatheter pulmonary valve replacement can find conduction isthmuses that might be 'jailed' and linked to ventricular tachycardia in people with repaired Tetralogy of Fallot.
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Registry for pediatric spine surgeries using robotics and navigation
This study is creating a registry to track pediatric spine surgeries that use robotics and navigation to see how these advanced techniques can improve treatment for kids with spine deformities.
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Blenderized diets for children with feeding intolerance
This study tests whether different types of blended diets can help children with feeding intolerance by seeing how they affect reflux symptoms.
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Genetic analysis of eye misalignment and related disorders
This study is trying to find out if there are specific genes that cause eye misalignment and related disorders by looking at families who have multiple members affected by these conditions.
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Registry for Early Onset Hereditary Spastic Paraplegia
This study is collecting information and samples from people under 30 with early onset hereditary spastic paraplegia to help understand the condition better and find new treatments.
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Understanding quality of life in children with intestinal failure
This study looks at how living with intestinal failure affects the quality of life for children and what factors might make it better or worse for them and their families.
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Examining health outcomes in children with congenital heart disease undergoing non-cardiac procedures
This study looks at how children with congenital heart disease do during and after non-heart surgeries to help doctors provide better care for them.
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Natural history study of Angelman Syndrome
This study is trying to learn more about how Angelman Syndrome affects children and adults over time to help improve care and future treatments.
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Effects of thickened feeds on swallowing in children with dysphagia
This study is testing if thickened liquids can help babies with swallowing problems do better when they eat.
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Effects of thickened feeds on infants with unexplained life-threatening events
This study is trying to see if giving thicker feeds to infants who have had scary unexplained events helps improve their health and reduces the need for medical care.
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Investigating the role of a genetic variant in worsening atopic dermatitis
This study is trying to see if a specific genetic change is connected to worse atopic dermatitis in people aged 6 to 65.
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Evaluating pain pathways and nerve regeneration in keratoconus patients after corneal crosslinking
This study is testing how corneal crosslinking affects pain and nerve healing in people with keratoconus to see how their pain changes over time.
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Extended versus short abatacept dosing to prevent graft-versus-host disease after mismatched unrelated donor transplant
This trial tests whether giving extra abatacept doses after a 7/8 matched unrelated donor stem cell transplant helps prevent severe acute and chronic graft-versus-host disease in patients already receiving standard calcineurin inhibitor plus methotrexate prophylaxis.
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High dose vitamin D for young patients with inflammatory bowel disease on biologic therapy
This study is testing if giving high doses of vitamin D to young people with inflammatory bowel disease who are on biologic treatments can improve their bone health and reduce inflammation.
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Evaluating immune cell activity in patients undergoing heart surgery
This study is trying to see how immune cell activity during heart surgery affects the risk of blood clots in patients.
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Understanding lung injury in young patients after heart surgery
This study looks at how heart surgery can cause lung injury in young patients by examining the role of certain immune cells to help improve their recovery.
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Low dose IL-2 treatment for Crohn's disease
This study is testing whether a low-dose treatment with a drug called IL-2 can help people with moderate-to-severe Crohn's disease feel better when other treatments haven't worked.
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Effects of a ketogenic diet on brain function in people with type 1 diabetes
This study is testing if a ketogenic diet can help young adults with type 1 diabetes better handle low blood sugar and improve their brain function.
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Exploring very low carbohydrate diets for managing Type 1 diabetes
This study is testing if a very low carbohydrate diet can help adults with Type 1 diabetes manage their blood sugar levels better and reduce the need for insulin.
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Monitoring brain health in children with Sickle Cell Disease
This study is trying to see how Sickle Cell Disease affects brain health in children aged 8-18 by using special imaging techniques to check blood flow and oxygen levels in the brain.
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Impact of early intervention on child development in foster care vs. institutional care
This study is testing whether young children in foster care develop better than those in enhanced institutional care to see which option helps them grow up healthier.
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Examining Neutrophils in Sepsis Patients
This study looks at the white blood cells called neutrophils in the blood and breathing tubes of sepsis patients to see how they behave and if they might be causing lung problems, with the hope of finding better treatments.
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Analyzing neutrophils in children with sepsis
This study looks at the white blood cells in children with sepsis to see how they differ from those in healthy kids, hoping to find clues for better treatments.
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Improving family counseling for extremely preterm deliveries
This study is trying to improve how doctors talk to families about extremely preterm deliveries to make sure they feel understood and supported during a tough time.
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Developing advanced MRI techniques for pediatric brain tumors
This study is testing new MRI techniques to see if they can help doctors get clearer images of brain tumors in children, making it easier to measure and understand the tumors.
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How SSADH deficiency affects people over time
This project will follow people with SSADH deficiency across ages to see how their symptoms, brain activity, and biochemical markers change over five years.
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Comparing how different amounts of clear fluids affect stomach contents in children before surgery
This study is testing how different amounts of clear fluids before surgery can affect the stomach contents of children aged 13 to 17 to find the best way to keep them hydrated and safe.
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Managing Type 1 Diabetes with Low Carbohydrate Diets
This study is testing if a very low carbohydrate diet can help people with type 1 diabetes manage their blood sugar better than a standard diet over 12 weeks.
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Measuring drug levels in children on ECMO support
This study is trying to see how well certain sedatives and pain medications work in children on ECMO support to improve their care.
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Measuring how bivalirudin works in children during heart procedures
This study is testing how the blood thinner bivalirudin works in children during heart procedures to help make sure they get the right amount for safety and effectiveness.
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Exploring a new way to help children with short bowel syndrome absorb nutrients
This study is testing a new device that helps children with short bowel syndrome absorb fats better from their feeding tube to see if it can reduce their need for intravenous nutrition.
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Using lung recruitment maneuvers to predict fluid needs in children under anesthesia
This study is testing if special breathing techniques can help doctors figure out if kids under anesthesia need extra fluids during surgery.
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Gene therapy for X-linked severe combined immunodeficiency using targeted busulfan conditioning
This study is testing a new gene therapy for patients with X-linked severe combined immunodeficiency to see if it can help their immune system work better after a special treatment to prepare their bodies.
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Genetic analysis of eye movement disorders and related conditions
This study is trying to find out if certain genes are linked to eye movement disorders like strabismus and other related conditions in people with and without these issues.
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Transplanting patients' own mitochondria to improve heart function after ischemia
This study is testing whether injecting children's own mitochondria into their heart can help improve heart function after a lack of blood flow during ECMO treatment.
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Improving fetal MRI imaging for pregnant women
This study is testing new ways to improve MRI scans for pregnant women to get clearer images of their babies while reducing movement during the scans.
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Monitoring brain health in newborns at risk of brain injuries
This study is testing a new device to monitor brain health in newborns at risk of brain injuries to see how oxygen levels affect their recovery during their hospital stay.
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Gene discovery for rare and undiagnosed genetic conditions
This study is trying to find the genetic causes of rare and undiagnosed conditions by collecting DNA and medical information from affected families to improve diagnosis and treatment options.
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Monitoring brain blood flow and oxygen in premature infants
This study is trying to see if monitoring blood flow and oxygen in the brains of premature infants with certain types of brain bleeding can help doctors understand how serious their condition is and how well treatments are working.
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Registry for patients with lymphatic anomalies
This study is collecting information from people with lymphatic anomalies to see how these conditions affect their health and treatment over time.
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Assessing placental health in pregnancies with growth restriction
This study is trying to find better ways to decide when to deliver babies at risk of stillbirth due to growth issues by looking at how well the placenta is working in pregnant women with these conditions.
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Identifying sources of bloodstream infections in children
This study is trying to find out where bloodstream infections in hospitalized children come from by looking at bacteria in different parts of their bodies and seeing if they match the bacteria in their blood.
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Comparing two surgical methods for fixing an undescended testicle in boys
This study is testing which of two surgical methods works better for fixing an undescended testicle in boys and how it affects their health and quality of life afterward.
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Understanding the genetics behind epilepsy and related disorders
This study is trying to find out how genes affect epilepsy and similar disorders in kids to help improve their diagnosis and treatment.
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Registry for patients with lung disease from premature birth
This study is collecting information from people who had lung problems after being born early to help improve care and understand their health better.
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Genetic analysis of chronic pelvic pain conditions
This study is trying to find out if certain genes are linked to chronic pelvic pain by collecting samples from people with the condition and their families.
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Identifying genes linked to neuromuscular diseases
This study is trying to find new genes linked to neuromuscular diseases by looking at muscle and skin samples from patients and their families to help improve diagnosis and treatment options.
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Identifying genetic causes of bladder pain syndrome
This study is trying to find out if there are genetic reasons behind bladder pain syndrome by collecting DNA and health information from people who have it and their families.
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Research on genetic causes of congenital myopathies
This study is trying to find out more about the genetic causes of congenital myopathies to help improve diagnosis and treatment for people born with these muscle diseases.
NIH-funded research (newest 40 of 858)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Targeting the brain’s fluid system to treat post-hemorrhagic hydrocephalus
This grant explores a new approach to treating post-hemorrhagic hydrocephalus by studying how the brain’s fluid system and immune cells manage CSF after a brain bleed.
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National Spina Bifida Patient Registry at Boston Children’s Hospital
A patient-focused registry project at Boston Children’s Hospital will collect and study information from people with spina bifida to improve care and outcomes.
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Severe Chronic Neutropenia Registry for Patients
A patient-facing registry that tracks severe chronic low neutrophil counts to improve understanding and care for people with this condition.
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Severe Chronic Neutropenia Registry to Improve Care
A patient-focused registry gathers information from adults with severe chronic neutropenia to better understand infections, treatments, and outcomes over time.
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Severe Chronic Neutropenia Registry: Finding Better Ways to Prevent Infections
A patient-focused registry at a leading hospital helps people with severe chronic neutropenia learn how the condition progresses and how treatments work over time.
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Exploring epilepsy genes in zebrafish to understand human brain seizures
A study in zebrafish will model human epilepsy genes to help explain how certain brain mutations contribute to seizures.
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Multicenter ECMO for Children: Cardiohelp System
A multicenter study tests whether the Cardiohelp ECMO circuit can safely support children with severe heart failure for up to 30 days.
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Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
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Targeting gut microbes to restore food-tolerance in adults
Aims to understand how gut bacteria and the lining of the gut interact to keep people with food allergies tolerant to what they eat.
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HIV-1 membrane fusion and its blockers in membranes and on virus surfaces
Aims to understand how HIV-1 fuses into human cells and how two kinds of blockers stop it, using advanced imaging on real virus-like membranes.
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Understanding brain signals in autism to identify biologically distinct subtypes
This study uses EEG to link how the brain processes sensory information with behavior in young children with autism and related concerns.
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IDDK Center at Boston Children’s/Harvard Medical School exploring genetic and cellular bases of developmental disorders with AI support
A center-funded program uses AI-enhanced methods to study genetic causes, cellular biology, and animal models of intellectual and developmental disabilities to speed new prevention and treatment ideas.
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Healthy Brain and Child Development across the first 10 years
This grant supports a large study following 7,200 mothers and their babies across 27 US sites to map how early life experiences shape brain development.
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IDEAL project helps predict vaccine response, infections, and asthma in early childhood
A Child-focused program will collect and share saliva, blood, and tissue samples from diverse infants to find biological patterns that predict how vaccines work, how respiratory infections occur, and who develops asthma.
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Understanding how early-life immune development affects vaccine responses and asthma risk in children
This project uses lab-grown human immune cells from infants and young children to explore why some kids respond poorly to vaccines and are more prone to respiratory infections and asthma.
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Multi-omic endotypes of vaccine response, respiratory infections, and asthma in children
A parent-friendly look at how early-life immune development shapes how kids respond to vaccines and stay free from lung infections and asthma, using advanced biological profiling.
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IDEAL: How early-life immune development shapes vaccine responses and asthma risk
A child-focused project that looks at how the developing immune system in early life affects vaccine responses, respiratory infections, and asthma.
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IDEAL: How the microbiome shapes vaccine response, infections, and asthma in kids
This project uses data from thousands of children to understand how the microbiome affects vaccines, respiratory infections, and asthma.
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IDEAL: How babies’ immune systems shape vaccines, infections and asthma
A large NIH project will build a cloud-based system to map how early-life immune development relates to vaccine responses, respiratory infections, and asthma in children.
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IDEAL: How immune systems develop in early life shape vaccines, infections, and asthma
A patient-friendly overview of a program at Boston Children’s Hospital exploring how early immune development affects vaccine responses, respiratory infections, and asthma in children.
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Natural history study of KIF1A-associated neurological disorder (KAND)
We’re studying how KAND progresses over time in people with different KIF1A mutations to find reliable ways to measure change.
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Accelerating Clinical Readiness for Shwachman-Diamond Syndrome
A study focused on speeding up how doctors prepare and enroll patients with Shwachman-Diamond Syndrome for clinical trials and treatment advancements.
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IDEAL: how immune development in infancy shapes vaccines, infections, and asthma
A multi-part NIH grant will study how babies’ immune systems develop to influence vaccine responses, respiratory infections, and asthma outcomes.
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Natural history of SSADH deficiency in adults and how it progresses
This project follows adults with SSADH deficiency over time to map how the condition changes and which biomarkers best predict progression.
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How flu antibodies attach to the virus
This project looks at how antibodies from people of different ages stick to flu virus proteins to help make better vaccines.
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Flu vaccine designs that target the HA and NA proteins
Developing vaccine pieces that teach the immune system to recognize shared parts of flu viruses so more people can get broader protection.
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How B cells learn to make stronger antibodies
Researchers are tracking how immune B cells change after flu exposure to help people get stronger, longer-lasting protection from vaccines and infections.
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How flu infection and vaccination shape B cell immune memory
This project compares how first flu infections versus first flu vaccines change antibody responses in children and adults to help make better vaccines.
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Memory B cell and antibody mapping
Maps memory B cells and the antibodies people make after flu vaccination or infection to understand immune protection.
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Pathways to arthritis flare persistence via resident memory T cells
A study to understand how memory T cells in joints keep rheumatoid arthritis and juvenile arthritis flares going, with the goal of new therapies.
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Understanding how multiple genetic changes drive cancer growth
A bold NIH project aims to map how many genetic changes work together to fuel cancer, with insights that could lead to new, less-drug-focused ways to treat many patients.
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How dopamine connections develop to control movement and motivation
A study at Boston Children’s Hospital looks at how dopamine brain circuits develop to influence movement, reward, and motivation, with potential relevance to ADHD.
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Genomic newborn screening: addressing big questions for babies and families
This project looks at how to responsibly use genome sequencing for newborn screening and what it means for babies, families, and care systems.
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Genetic and immune clues in pediatric paroxysmal nocturnal hemoglobinuria (PNH)
A multi-institution study in children with PNH looks for genetic and immune markers that explain how the disease presents and progresses.
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Clinical and multi-omic clues to pediatric bone marrow failure
A study at Boston Children’s Hospital will look at young people with unexplained bone marrow failure using clinical data and advanced molecular analysis to better classify the condition and guide future trials.
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Clinical and immunologic study of pediatric severe aplastic anemia to personalize care
A pediatric-focused research effort will collect and study immune and clinical data to tailor treatments for children with severe aplastic anemia.
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Pediatric Bone Marrow Failure Network Career Enhancement Core (pBMFN CEC)
A career-boosting program to mentor and train the next generation of pediatric bone marrow failure specialists.
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Pediatric Bone Marrow Failure Network: Pilot & Feasibility Governance Core
A program at Boston Children’s Hospital funds and mentors early-career researchers to pilot promising studies about pediatric bone marrow failure and to connect researchers with patients and families.
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Pediatric Bone Marrow Failure Network Administrative Core
A network-wide administrative core supports coordinated care, research, and future clinical trials for children with bone marrow failure.
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Pediatric Bone Marrow Failure Network (pBMFN) to improve care for children with aplastic anemia
A nationwide effort to understand and improve diagnosis, treatment, and long-term health for children with rare bone marrow failures like aplastic anemia.
Quick answers
How many clinical trials run by Boston Children's Hospital are recruiting right now?
104, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 6 countries. The most sites are in United States (103 trials), Canada (3 trials), Spain (2 trials), Germany (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1/2: 6, Phase 4: 4, Phase 1: 4, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.