Clinical and multi-omic clues to pediatric bone marrow failure
Official title: Project 2: Clinical and multi-omic deconvolution of idiopathic bone marrow failure in children
Funded at Boston Children's Hospital · NIH-11453342 · Data updated 2026-11-12
A study at Boston Children’s Hospital will look at young people with unexplained bone marrow failure using clinical data and advanced molecular analysis to better classify the condition and guide future trials.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 21, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $427,842 |
| NIH project number | 1U54HD123051-01 |
| Project ID | NIH-11453342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are children with unexplained bone marrow failure where other causes have been ruled out.
✕Less likely to help
Patients whose bone marrow failure is clearly due to another identifiable cause or who are not eligible due to age or health conditions may not directly benefit.
What this research studies
This project aims to clarify why idiopathic bone marrow failure occurs in children by combining clinical information with multiple types of biological data. Researchers will deconvolute complex molecular signals to distinguish subtypes that may have different causes and outcomes. The goal is to improve diagnosis, readiness for future trials, and targeted care for affected kids. The study is designed to inform how to enroll patients in future therapies and understand how pediatric biology differs from adults in this condition.
Why it matters
Potential benefit: If successful, the research could lead to more precise diagnoses and pave the way for targeted treatments for children with idiopathic bone marrow failure.
How similar studies have gone: Prior work in pediatric bone marrow disorders has shown value in multi-omics classification, but pediatric-specific deconvolution remains an emerging area.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Shimamura, Akiko — Boston Children's Hospital
- Study coordinator: Shimamura, Akiko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.