Multi-omic endotypes of vaccine response, respiratory infections, and asthma in children
Official title: Project 1: Multi-omic endotyping of vaccine response, susceptibility to respiratory infectious disease and asthma
Funded at Boston Children's Hospital · NIH-11496691 · Data updated 2026-11-12
A parent-friendly look at how early-life immune development shapes how kids respond to vaccines and stay free from lung infections and asthma, using advanced biological profiling.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2026 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $322,112 |
| NIH project number | 5U19AI168643-05 |
| Project ID | NIH-11496691 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children in the early years, particularly those at risk for airway infections or asthma, who can undergo follow-up and provide biological samples.
✕Less likely to help
Children not falling within the IDEAL endotype spectrum or unable to participate in longitudinal follow-up may not benefit.
What this research studies
This project studies young children to understand why some kids respond differently to vaccines and why some develop asthma or frequent respiratory infections. Researchers will collect and analyze multiple types of biological data across time to identify distinct immune endotypes that underlie these outcomes. The goal is to use these insights to predict immune trajectories and guide personalized prevention strategies in pediatric care. The study emphasizes longitudinal follow-up and integration of clinical data with comprehensive biology to reveal actionable biomarkers.
Why it matters
Potential benefit: If successful, it could lead to personalized approaches that improve vaccine responses and reduce asthma risk in children.
How similar studies have gone: Prior research suggests multiomic profiling can reveal immune endotypes, but applying this to pediatric vaccine and asthma trajectories is an emerging area.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Levy, Ofer — Boston Children's Hospital
- Study coordinator: Levy, Ofer
Related research
Other NIH-funded projects on the same topics.
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IDEAL project helps predict vaccine response, infections, and asthma in early childhood
A Child-focused program will collect and share saliva, blood, and tissue samples from diverse infants to find biological patterns that predict how vaccines work, how respiratory infections occur, and who develops asthma.
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Understanding how early-life immune development affects vaccine responses and asthma risk in children
This project uses lab-grown human immune cells from infants and young children to explore why some kids respond poorly to vaccines and are more prone to respiratory infections and asthma.
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IDEAL: How early-life immune development shapes vaccine responses and asthma risk
A child-focused project that looks at how the developing immune system in early life affects vaccine responses, respiratory infections, and asthma.
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IDEAL: How the microbiome shapes vaccine response, infections, and asthma in kids
This project uses data from thousands of children to understand how the microbiome affects vaccines, respiratory infections, and asthma.
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IDEAL: How babies’ immune systems shape vaccines, infections and asthma
A large NIH project will build a cloud-based system to map how early-life immune development relates to vaccine responses, respiratory infections, and asthma in children.
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IDEAL: How immune systems develop in early life shape vaccines, infections, and asthma
A patient-friendly overview of a program at Boston Children’s Hospital exploring how early immune development affects vaccine responses, respiratory infections, and asthma in children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.