Developing advanced MRI techniques for pediatric brain tumors
Developing Fast Pediatric Imaging
This study is testing new MRI techniques to see if they can help doctors get clearer images of brain tumors in children, making it easier to measure and understand the tumors.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 0 Years and up |
| Sex | All |
| Sponsor | Boston Children's Hospital Academic / other |
| Locations | 3 sites (Boston, Massachusetts and 2 other locations) |
| Trial ID | NCT03761121 on ClinicalTrials.gov |
What this trial studies
This research focuses on creating new software and techniques to enhance magnetic resonance imaging (MRI) for better evaluation of pediatric low-grade gliomas. The study aims to improve the sensitivity, specificity, and efficiency of MRI systems, allowing for more accurate measurements of brain tumor tissues. By testing investigational software, the researchers will collect and analyze MR images to refine image quality and reconstruction methods, ultimately leading to improved assessment of tumor volume.
Who should consider this trial
Good fit: Ideal candidates include infants and children diagnosed with low-grade gliomas, as well as healthy volunteers of all ages.
Not a fit: Patients with electrical or ferromagnetic implants, certain medical conditions, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this could lead to more accurate diagnoses and treatment plans for children with low-grade gliomas.
How similar studies have performed: Other studies have shown promise in improving MRI techniques, but this specific approach is novel in its focus on pediatric low-grade gliomas.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Infants, children and adults who have been diagnosed with Low Grade Glioma * Healthy volunteers - Children from age 0 to adults with no upper age limit or; * Diagnosed with LGG and being treated at DFCI; Exclusion Criteria: * Electrical implants such as cardiac pacemakers or perfusion pumps; * Ferromagnetic implants such as aneurysm clips, surgical clips, prosthesis, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants; * Ferromagnetic objects such as jewelry or metal clips; * Women of childbearing age who are seeking to become pregnant, who are breastfeeding, or who suspect they may be pregnant; * Pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions; * Any greater than normal potential for cardiac arrest
Where this trial is running
Boston, Massachusetts and 2 other locations
- Massachusetts General Hospital — Boston, Massachusetts, United States (Recruiting)
- Boston Children Hospital — Boston, Massachusetts, United States (Recruiting)
- Dana Farber Cancer Institute — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Kawin Setsompop, PhD — Boston Children Hospital/ Massachusetts General Hospital
- Study coordinator: Kawin Setsompop, PhD
- Email: kawin@nmr.mgh.harvard.edu
- Phone: 617-669-6640
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.