Developing advanced MRI techniques for pediatric brain tumors
Official title: Developing Fast Pediatric Imaging
Run by Boston Children's Hospital · NCT03761121 · Data updated 2026-11-12
This study is testing new MRI techniques to see if they can help doctors get clearer images of brain tumors in children, making it easier to measure and understand the tumors.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 0 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Boston Children's Hospital Academic / other |
| Locations | 3 sites (Boston, Massachusetts and 2 other locations) |
| Status | Recruiting |
| Started | April 15, 2019 |
| Main results expected | September 1, 2027 |
| Study ends | March 1, 2028 |
| Registry record updated | December 12, 2025 |
| Trial ID | NCT03761121 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include infants and children diagnosed with low-grade gliomas, as well as healthy volunteers of all ages.
✕Probably not a fit
Patients with electrical or ferromagnetic implants, certain medical conditions, or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research focuses on creating new software and techniques to enhance magnetic resonance imaging (MRI) for better evaluation of pediatric low-grade gliomas. The study aims to improve the sensitivity, specificity, and efficiency of MRI systems, allowing for more accurate measurements of brain tumor tissues. By testing investigational software, the researchers will collect and analyze MR images to refine image quality and reconstruction methods, ultimately leading to improved assessment of tumor volume.
Why it matters
Potential benefit: If successful, this could lead to more accurate diagnoses and treatment plans for children with low-grade gliomas.
How similar studies have gone: Other studies have shown promise in improving MRI techniques, but this specific approach is novel in its focus on pediatric low-grade gliomas.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Infants, children and adults who have been diagnosed with Low Grade Glioma * Healthy volunteers - Children from age 0 to adults with no upper age limit or; * Diagnosed with LGG and being treated at DFCI; Exclusion Criteria: * Electrical implants such as cardiac pacemakers or perfusion pumps; * Ferromagnetic implants such as aneurysm clips, surgical clips, prosthesis, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants; * Ferromagnetic objects such as jewelry or metal clips; * Women of childbearing age who are seeking to become pregnant, who are breastfeeding, or who suspect they may be pregnant; * Pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions; * Any greater than normal potential for cardiac arrest
Where it's running
-
Massachusetts General Hospital
Boston, Massachusetts, United States Recruiting -
Boston Children Hospital
Boston, Massachusetts, United States Recruiting -
Dana Farber Cancer Institute
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Kawin Setsompop, PhD — Boston Children Hospital/ Massachusetts General Hospital
- Study coordinator: Kawin Setsompop, PhD
- Email: kawin@nmr.mgh.harvard.edu
- Phone: 617-669-6640
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.