Transplanting patients' own mitochondria to improve heart function after ischemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This intervention aims to reduce myocardial ischemia/reperfusion injury in pediatric patients on extracorporeal membrane oxygenation (ECMO) by injecting autologous mitochondria directly into the ischemic heart muscle. The mitochondria are extracted from the patient's own skeletal muscle during a surgical procedure or cardiac catheterization and then injected into the damaged area or the proximal aorta for distribution. This approach seeks to enhance heart recovery and minimize complications associated with ECMO. The study will evaluate the safety and efficacy of this innovative treatment method.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pediatric cardiology patients under the age of 18 on ECMO
* concerns for ischemic injury on the Cardiac Intensive Care Unit

Exclusion Criteria:

* Known mitochondria disorders

Where it's running

• Boston Children's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Sitaram M Emani, MD — Boston Children's Hospital
• Study coordinator: Breanna Piekarski, RN, BSN
• Email: breanna.piekarski@cardio.chboston.org
• Phone: 617-919-4457

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.