Using lung recruitment maneuvers to predict fluid needs in children under anesthesia
Official title: Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients
Run by Boston Children's Hospital · NCT03431064 · Data updated 2026-11-12
This study is testing if special breathing techniques can help doctors figure out if kids under anesthesia need extra fluids during surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 17 Years |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | Boston Children's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | June 21, 2018 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | November 12, 2025 |
| Trial ID | NCT03431064 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children aged 0 to under 18 years who are undergoing surgery under general anesthesia and are mechanically ventilated.
✕Probably not a fit
Patients with conditions such as congenital heart disease, pulmonary hypertension, or those requiring single lung ventilation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the effectiveness of non-invasive tools, specifically lung recruitment maneuvers, in predicting whether mechanically ventilated pediatric patients under general anesthesia will require fluid administration. By monitoring these patients, anesthesiologists can better determine the optimal intervention for managing low blood pressure and avoid unnecessary treatments. The study will involve children aged 0 to under 18 years who are undergoing surgery at Boston Children's Hospital and are monitored with an indwelling radial arterial catheter.
Why it matters
Potential benefit: If successful, this approach could lead to more tailored fluid management in pediatric patients, improving their surgical outcomes.
How similar studies have gone: While the use of non-invasive tools in fluid management is a growing area of interest, this specific approach has not been extensively tested in pediatric populations, making it a novel investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 0 to \< 18 years old * Undergoing surgery at Boston Children's Hospital under general anesthesia * mechanically ventilated with an endotracheal tube * Monitored with an indwelling radial arterial catheter as part of the anesthetic plan for the scheduled surgical procedure Exclusion Criteria: * Prematurity * Low birth weight * Congenital heart disease * Left or right ventricular dysfunction * Cardiac arrhythmia * Pulmonary hypertension * Preoperative parenchymal or interstitial lung disease * Intracranial hypertension * Poor transthoracic acoustic window * Obesity * Allergy to ultrasound transmission gel * Need for single lung ventilation * Systemic hypertension on antihypertensive medications
Where it's running
-
Boston Children's Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Viviane Nasr, MD — Boston Children's Hospital
- Study coordinator: Viviane Nasr, MD
- Email: viviane.nasr@childrens.harvard.edu
- Phone: 617-355-6225
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.