Understanding lung injury in young patients after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the mechanisms behind acute lung injury (ALI) that can occur in pediatric patients following cardiopulmonary bypass (CPB) during cardiac surgery. It focuses on the role of neutrophils, which are immune cells that can contribute to lung damage when activated during CPB. By analyzing the behavior and characteristics of these neutrophils, the study seeks to provide insights into how CPB affects lung function and potentially leads to serious complications like acute respiratory distress syndrome. The findings could help improve postoperative care and outcomes for affected patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Are \< 12months of age
* Scheduled for cardiac surgical needing CPB
* Preoperative SpO2 \> 90%

Exclusion Criteria:

* Lack of parental (or legal guardian's) consent
* Preoperative SpO2 \< 90%
* Preoperative oxygen therapy

Where it's running

• Boston Children's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Sophia Koutsogiannaki, PhD
• Email: sophia.koutsogiannaki@childrens.harvard.edu
• Phone: 617-919-4725

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Optimized Flow for Obese Patients Undergoing Heart Surgery

  In this study, researchers will test whether using ideal body weight to set cardiopulmonary bypass flow during heart surgery helps obese adults see fewer transfusions and related complications.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07917494

• Integrated intraoperative hemodynamic monitoring during cardiac surgery with CPB

  This pilot study tests a single-dashboard monitoring system to see if it can capture heart and tissue perfusion data during elective cardiac surgery with bypass in adults without changing patient care.

  Recruiting Hernán Darío Castro Arias MD MSc · Medellín, Antioquia · NCT07683299

• Preventive Narrative Exposure for PTSD After Cardiac Surgery in the ICU

  In adults having cardiopulmonary bypass heart surgery, this trial tests whether an ICU-based narrative exposure intervention helps prevent posttraumatic stress symptoms compared with standard care.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT07632131

• Impact of cardiopulmonary bypass on platelet lipids and bleeding after cardiac surgery

  This study tests how CPB changes platelet lipid metabolism and procoagulant platelets to see if these changes relate to inflammation and bleeding after cardiac surgery.

  Recruiting Université Catholique de Louvain · Brussels · NCT07630987

• Transcutaneous auricular vagus nerve stimulation to prevent kidney injury after heart surgery

  This trial tests whether applying a non-invasive ear stimulation (taVNS) around the time of elective heart surgery can help prevent acute kidney injury in adults undergoing cardiopulmonary bypass.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT07549243

• Femorofemoral versus left‑heart bypass for open thoracoabdominal aortic aneurysm repair

  This will test whether femorofemoral bypass or left‑heart bypass works better for adults having open repair of a thoracoabdominal aortic aneurysm.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07518251

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.