TransHealthGUIDE: Digital support for gender-diverse young adults and their caregivers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial assigns transgender and gender-diverse young adults (ages 18-29) and their caregivers to immediate access to an interactive educational app plus usual care or to a deferred-access usual care arm. The digital platform delivers educational modules and supportive resources and is available to participants for six months with continued observation through 12 months. The primary outcome is reduction in suicidal ideation; secondary outcomes include psychological distress, anxiety, and measures of caregiver support and communication, with assessments at baseline, 3, 6, and 12 months. Analyses follow intention-to-treat and the investigators plan for at least 80% retention to detect a clinically meaningful change in suicidal ideation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Gender diverse individuals aged 18-29 years residing in California, Oregon, Illinois, Maryland, District of Columbia, Vermont, Connecticut, Massachusetts, Michigan, New Jersey, or New York
* Caregivers of gender diverse individuals aged 18-29 years residing in California, Oregon, Illinois, Maryland, District of Columbia, Vermont, Connecticut, Massachusetts, Michigan, New Jersey, or New York

Exclusion Criteria:

* Inability to speak, read, and write English
* Lack of device with Internet access
* Current residence in location other than California, Oregon, Illinois, Maryland, District of Columbia, Vermont, Connecticut, Massachusetts, Michigan, New Jersey, or New York

Where it's running

• Boston Children's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Rena Xu — Boston Children's Hospital
• Study coordinator: Cassandra Program Manager
• Email: theguide@childrens.harvard.edu
• Phone: 617-919-1369

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.