Examining Neutrophils in Sepsis Patients
Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis
This study looks at the white blood cells called neutrophils in the blood and breathing tubes of sepsis patients to see how they behave and if they might be causing lung problems, with the hope of finding better treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 2 Years to 50 Years |
| Sex | All |
| Sponsor | Boston Children's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT04103281 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the characteristics of neutrophils found in the blood and secretions from the breathing tubes of patients suffering from sepsis. Sepsis is a severe infection that can affect multiple body systems, and neutrophils play a crucial role in the immune response. By analyzing these white blood cells, researchers hope to understand their behavior and potential harmful effects in sepsis, which could lead to the development of targeted therapies to mitigate lung injury caused by these cells.
Who should consider this trial
Good fit: Ideal candidates include ICU patients diagnosed with sepsis who require a breathing tube.
Not a fit: Patients on chronic immunosuppressive drugs or with preexisting immunodeficiency diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved therapies that prevent neutrophils from causing harm in sepsis patients.
How similar studies have performed: While the specific approach of examining neutrophil profiles in sepsis is novel, similar studies have shown promise in understanding immune responses in critical conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Case Inclusion Criteria: * sepsis patient in the ICU with a breathing tube Control Inclusion Criteria: * scheduled for an elective surgical procedure and need preoperative blood draw or will have an intravenous catheter placed for the purpose of their surgical procedure * Plan to have endotracheal tube for planned procedures. Exclusion Criteria: * On chronic immunosuppressive drugs such as chronic corticosteroid use, or preexisting immunodeficiency diseases (oncology patients, patients with transplantation)
Where this trial is running
Boston, Massachusetts
- Boston Children's Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Koichi Yuki, MD — Boston Children's Hospital
- Study coordinator: Koichi Yuki, MD
- Email: koichi.yuki@childrens.harvard.edu
- Phone: 617-355-6225
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.