Genetic analysis of chronic pelvic pain conditions
Official title: Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
Run by Boston Children's Hospital · NCT00499317 · Data updated 2026-11-12
This study is trying to find out if certain genes are linked to chronic pelvic pain by collecting samples from people with the condition and their families.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Boston Children's Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | January 15, 2007 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2028 |
| Registry record updated | June 11, 2026 |
| Trial ID | NCT00499317 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals experiencing symptoms of CP/CPPS for at least three months, as well as family members of affected individuals.
✕Probably not a fit
Patients with major structural urinary tract abnormalities or those with bacterial causes of CP/CPPS may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the potential genetic factors associated with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) by collecting DNA, urine, and bladder tissue samples from affected individuals and their family members. Participants will undergo genetic testing, including linkage analysis and whole exome sequencing, to explore correlations between symptoms and genetic changes. The study seeks to enhance understanding of the condition's etiology and may lead to improved diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this study could provide insights into the genetic basis of CP/CPPS, potentially leading to better-targeted treatments for patients.
How similar studies have gone: While genetic studies in similar conditions have shown promise, this specific approach to CP/CPPS is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Have symptoms for at least 3 months within the preceding 6 months: * Pain in the pelvic area * Urinary frequency and/or * Urinary urgency and/or * Sexual dysfunction (erectile dysfunction) * Have CP/CPPS, Interstitial Cystitis (IC), Bladder Pain Syndrome BPS, or Bladder Fasciculation Syndrome (BFS) * Be willing to provide a blood/saliva, bladder tissue (from previous biopsy) and urine sample * Agree to complete several brief questionnaires * Family member of someone with CP/CPPS, BPS, IC or BFS * Live in the USA or Canada Exclusion Criteria: * Major structural/anatomical urinary tract abnormalities * Underlying inborn or congenital conditions which affect the urinary tract * Surgery/chemotherapy in the pelvic area * Bacterial cause to CP/CPPS or recurrent Urinary tract infections (UTI) * Traumatic cause to CP/CPPS
Where it's running
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Boston Children's Hospital (BCH)
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Catherine Brownstein, PhD — Boston Children's Hospital
- Study coordinator: Elicia Estrella, MS, LCGC
- Email: elicia.estrella@childrens.harvard.edu
- Phone: 617-919-4552
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using amniotic membrane therapy to treat interstitial cystitis and painful bladder syndrome
This study is testing whether injections of amniotic membrane therapy can help people with interstitial cystitis and painful bladder syndrome feel less pain and improve their urinary symptoms.
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Aerobic Exercise and Massage for Painful Bladder Syndrome in Women
This study tests whether adding aerobic exercise and connective tissue massage to patient education helps reduce bladder pain and improve symptoms for women with bladder pain syndrome.
-
Kinesiophobia, Activity, Sleep, and Quality of Life in Women With Chronic Pelvic Pain
This study tests how fear of movement relates to activity, sleep, and overall quality of life in women with chronic pelvic pain compared to healthy women.
-
Oxiblume:CoQ10 Therapy for Chronic Prostatitis and Pelvic Pain
A double-blind, placebo-controlled test to see if Oxiblume:CoQ10 helps people aged 18–50 with Chronic Prostatitis/Chronic Pelvic Pain Syndrome.
-
Exploring ozone therapy for chronic pelvic pain in women with gynecological cancers
This study is testing whether ozone therapy can help relieve chronic pelvic pain in women with gynecological cancers after their cancer treatments.
-
Remote pelvic floor yoga program for chronic pelvic pain
This study tests whether a remote yoga program can help women with chronic pelvic pain feel better compared to a regular physical conditioning program.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.