Genetic analysis of chronic pelvic pain conditions
Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
This study is trying to find out if certain genes are linked to chronic pelvic pain by collecting samples from people with the condition and their families.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Sex | Male |
| Sponsor | Boston Children's Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT00499317 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the potential genetic factors associated with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) by collecting DNA, urine, and bladder tissue samples from affected individuals and their family members. Participants will undergo genetic testing, including linkage analysis and whole exome sequencing, to explore correlations between symptoms and genetic changes. The study seeks to enhance understanding of the condition's etiology and may lead to improved diagnostic and therapeutic strategies.
Who should consider this trial
Good fit: Ideal candidates include individuals experiencing symptoms of CP/CPPS for at least three months, as well as family members of affected individuals.
Not a fit: Patients with major structural urinary tract abnormalities or those with bacterial causes of CP/CPPS may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the genetic basis of CP/CPPS, potentially leading to better-targeted treatments for patients.
How similar studies have performed: While genetic studies in similar conditions have shown promise, this specific approach to CP/CPPS is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Have symptoms for at least 3 months within the preceding 6 months: * Pain in the pelvic area * Urinary frequency and/or * Urinary urgency and/or * Sexual dysfunction (erectile dysfunction) * Have CP/CPPS, Interstitial Cystitis (IC), Bladder Pain Syndrome BPS, or Bladder Fasciculation Syndrome (BFS) * Be willing to provide a blood/saliva, bladder tissue (from previous biopsy) and urine sample * Agree to complete several brief questionnaires * Family member of someone with CP/CPPS, BPS, IC or BFS * Live in the USA or Canada Exclusion Criteria: * Major structural/anatomical urinary tract abnormalities * Underlying inborn or congenital conditions which affect the urinary tract * Surgery/chemotherapy in the pelvic area * Bacterial cause to CP/CPPS or recurrent Urinary tract infections (UTI) * Traumatic cause to CP/CPPS
Where this trial is running
Boston, Massachusetts
- Boston Children's Hospital (BCH) — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Catherine Brownstein, PhD — Boston Children's Hospital
- Study coordinator: Elicia Estrella, MS, LCGC
- Email: elicia.estrella@childrens.harvard.edu
- Phone: 617-919-4552
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.