Severe Chronic Neutropenia Registry: Finding Better Ways to Prevent Infections
Official title: Severe Chronic Neutropenia International Registry
Funded at Boston Children's Hospital · NIH-11614270 · Data updated 2026-11-12
A patient-focused registry at a leading hospital helps people with severe chronic neutropenia learn how the condition progresses and how treatments work over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 25, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $8,276 |
| NIH project number | 3R24AI162637-05S1 |
| Project ID | NIH-11614270 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with severe chronic neutropenia who are or have been treated with G-CSF or who have related neutropenia conditions.
✕Less likely to help
Patients not involved in data sharing or those without SCN-related issues may see no direct benefit.
What this research studies
This project continues a long-running international registry that collects data from adults with severe chronic neutropenia to understand infection risks and outcomes. It uses modern data tools, patient-reported outcomes, and advances in biology to improve how we manage neutropenia and prevent serious infections. The registry collaborates with researchers to identify new treatment options and optimize medical care based on real-world experiences. Patients benefit from evidence that guides safer, more effective management of their condition.
Why it matters
Potential benefit: If successful, the registry could lead to better treatments and clearer guidance for preventing infections in people with SCN.
How similar studies have gone: The SCNIR has a history of productive research and many publications guiding care for neutropenia.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Shimamura, Akiko — Boston Children's Hospital
- Study coordinator: Shimamura, Akiko
Related research
Other NIH-funded projects on the same topics.
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Severe Chronic Neutropenia Registry for Patients
A patient-facing registry that tracks severe chronic low neutrophil counts to improve understanding and care for people with this condition.
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Severe Chronic Neutropenia Registry to Improve Care
A patient-focused registry gathers information from adults with severe chronic neutropenia to better understand infections, treatments, and outcomes over time.
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Stimulant that grows donor stem cells in the body to speed neutropenia recovery after chemotherapy and stem cell transplant
A drug given during or right before stem cell transplant helps donor stem cells multiply quickly inside the patient to shorten neutropenia after treatment.
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A new drug given briefly before transplant aims to help patients recover their blood and immune system faster after chemotherapy or stem cell transplant.
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PointCheck: a home-based, non-invasive neutropenia monitor for chemotherapy patients
A portable, non-invasive device helps cancer patients on chemotherapy monitor neutropenia from home so doctors can prevent serious infections.
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Understanding how DARC/ACKR1 genetic differences affect white blood cell counts in African Americans
A study explores how a common genetic variant tied to DARC/ACKR1 affects white blood cell and neutrophil counts in African American people, to help clinicians interpret these tests more accurately.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.