Measuring drug levels in children on ECMO support

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to measure the plasma concentrations of sedatives and analgesics, specifically dexmedetomidine, fentanyl, morphine, and midazolam, in pediatric patients who are receiving extracorporeal membrane oxygenation (ECMO) support. By understanding the pharmacokinetics of these medications in this unique clinical setting, the study seeks to optimize sedation management for these critically ill patients. The research will involve monitoring drug levels to assess how ECMO affects the metabolism and effectiveness of these drugs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* supported on ECMO
* receiving one or a combination of the following drugs dexmedetomidine, fentanyl, midazolam or morphine as part of sedation management

Exclusion Criteria:

-none

Where it's running

• Boston Children's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Viviane Nasr, MD — Boston Children's Hospital
• Study coordinator: Viviane Nasr, MD
• Email: viviane.nasr@childrens.harvard.edu
• Phone: 617-355-6225

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.