Measuring drug levels in children on ECMO support
Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support
This study is trying to see how well certain sedatives and pain medications work in children on ECMO support to improve their care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 0 Days to 17 Years |
| Sex | All |
| Sponsor | Boston Children's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT03593408 on ClinicalTrials.gov |
What this trial studies
This observational study aims to measure the plasma concentrations of sedatives and analgesics, specifically dexmedetomidine, fentanyl, morphine, and midazolam, in pediatric patients who are receiving extracorporeal membrane oxygenation (ECMO) support. By understanding the pharmacokinetics of these medications in this unique clinical setting, the study seeks to optimize sedation management for these critically ill patients. The research will involve monitoring drug levels to assess how ECMO affects the metabolism and effectiveness of these drugs.
Who should consider this trial
Good fit: Ideal candidates for this study are pediatric patients who are currently supported on ECMO and receiving one or more of the specified sedative or analgesic medications.
Not a fit: Patients not on ECMO or not receiving the specified medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved sedation management and better outcomes for pediatric patients on ECMO.
How similar studies have performed: While this study focuses on a specific patient population, similar pharmacokinetic studies in critically ill patients have shown promising results in optimizing drug dosing.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * supported on ECMO * receiving one or a combination of the following drugs dexmedetomidine, fentanyl, midazolam or morphine as part of sedation management Exclusion Criteria: -none
Where this trial is running
Boston, Massachusetts
- Boston Children's Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Viviane Nasr, MD — Boston Children's Hospital
- Study coordinator: Viviane Nasr, MD
- Email: viviane.nasr@childrens.harvard.edu
- Phone: 617-355-6225
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.