Research on genetic causes of congenital myopathies

Molecular Analysis of Neuromuscular Disease

Boston Children's Hospital · NCT00272883

This study is trying to find out more about the genetic causes of congenital myopathies to help improve diagnosis and treatment for people born with these muscle diseases.

Quick facts

Study typeObservational
Enrollment4000 (estimated)
SexAll
SponsorBoston Children's Hospital (other)
Locations1 site (Boston, Massachusetts)
Trial IDNCT00272883 on ClinicalTrials.gov

What this trial studies

The Congenital Myopathy Research Program at Boston Children's Hospital and Harvard Medical School focuses on understanding congenital myopathies, which are neuromuscular diseases present from birth. Researchers are identifying new genes and proteins involved in muscle function and studying genetic mutations that lead to these conditions. The program encourages participation from individuals with congenital myopathies and their families, who contribute medical records and biological samples for analysis. This research aims to improve diagnosis and treatment options for affected individuals in the future.

Who should consider this trial

Good fit: Ideal candidates include individuals with a clinical or suspected diagnosis of congenital myopathy and their first-degree relatives.

Not a fit: Patients with myotonia congenita or related conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for patients with congenital myopathies.

How similar studies have performed: Other studies have shown success in identifying genetic causes of neuromuscular diseases, making this approach promising.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Individuals with a clinical or suspected diagnosis of a congenital myopathy and their family members

Exclusion Criteria:

* No specific exclusion criteria. Our studies do not include myotonia congenita or related conditions.

Where this trial is running

Boston, Massachusetts

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Central Core Disease, Centronuclear Myopathy, Congenital Fiber Type Disproportion, Multiminicore Disease, Myotubular Myopathy, Nemaline Myopathy, Rigid Spine Muscular Dystrophy, Undefined Congenital Myopathy

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.