Impact of THC on E-Cigarette Use Behavior

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how tetrahydrocannabinol (THC) affects the use of electronic cigarettes among daily users. It employs a double-blind, placebo-controlled, within-subjects crossover design to assess the motivational, subjective, and physiological responses to varying doses of THC. Participants will be administered either smoked or vaporized THC while their e-cigarette use, cravings, heart rate, blood pressure, and cognitive performance are monitored. The goal is to understand the relationship between THC and e-cigarette behavior in a controlled laboratory setting.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Healthy non-treatment seeking adults aged 21 or older
2. Report daily use of e-cigarettes
3. Biological confirmation of e-cigarette use: have a positive urine cotinine test at screening
4. Report current use of cannabis (at least 1 occasion per week)
5. Have experience with the inhalation route of administration for cannabis
6. Biological confirmation of cannabis use: have a positive urinary THC drug test at screening.
7. For women of children bearing potential and men with female partners of child-bearing potential, must be willing to use an effective form of contraception during the study.

Exclusion criteria:

1. Report current intention to reduce or quit cannabis or tobacco use within the next 30 days
2. Meet Diagnostic and Statistical Manual (DSM-5) criteria for a substance use disorder other than alcohol, cannabis, or nicotine
3. Test positive for illicit drugs other than cannabis and tobacco
4. Positive breath alcohol test at study admission
5. Have a current physical or mental illness judged by the study team to negatively impact participant safety or scientific integrity
6. Have a lifetime history of suicidal behavior (i.e. past suicide attempt), or current suicidal behavior or ideation as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)
7. Are currently pregnant, planning to become pregnant in the next three months or are currently breastfeeding
8. Have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina)
9. Are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.

Where it's running

• Johns Hopkins University Behavioral Pharmacology Research Unit
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Dustin Lee, PhD — Johns Hopkins School of Medicine
• Study coordinator: Lauren Brogdon, MHS
• Email: lmorri20@jhmi.edu
• Phone: 410-550-6953

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.