Using virtual reality to understand how attention affects tobacco addiction

Advancing VR-based attentional bias as a biomarker for tobacco use disorder

NIH-funded research University of California, San Diego · NIH-11164800

This study is looking at how daily tobacco users react to virtual reality situations that remind them of smoking, to see if their attention to these cues can help predict how well they might do with quitting smoking, especially when using a medication called varenicline compared to a placebo.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Diego NIH-funded
Lab location1 site (La Jolla, United States)
Project IDNIH-11164800 on NIH RePORTER

What this research studies

This research investigates how attentional bias, a behavioral indicator of addiction, can be measured using a virtual reality (VR) nicotine cue exposure paradigm. Participants who are daily tobacco users will engage with VR scenarios designed to trigger nicotine-related cues, allowing researchers to assess their attentional responses. The study aims to validate this attentional bias as a biomarker for tobacco use disorder and explore its potential in predicting treatment outcomes for smoking cessation. By comparing responses to a medication called varenicline versus a placebo, the research seeks to enhance the development of effective smoking cessation therapies.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who are daily cigarette smokers.

Not a fit: Patients who do not smoke or are not interested in quitting smoking may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment options for individuals struggling with tobacco addiction.

How similar studies have performed: Previous research has shown promising results using similar virtual reality approaches to assess attentional bias in addiction, indicating potential for success in this novel application.

Where this research is happening

La Jolla, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions addictive disorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.