How people puff IQOS Iluma i vs IQOS 2.4 and how flavors feel

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized crossover study compares puff topography and sensory responses among 50 exclusive IQOS users. Participants use both IQOS Iluma i and IQOS 2.4 across two laboratory visits, with order randomized. Puffing behavior is recorded during ad-libitum use, and chemosensory ratings and subjective effects are collected after each session. The study also compares preferred versus standard flavor to see if flavor shifts influence throat hit, mouthfeel, and satisfaction. Findings will inform device-specific puffing regimens for future emissions assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Current IQOS user (at least 3 days per week in the past 30 days)
* Age 18 to 65 years
* Generally healthy
* Willing to provide informed written consent
* Willing to attend all laboratory visits
* Willing to abstain from all nicotine and tobacco products for at least 12 hours before each visit

Exclusion Criteria:

* Use of any tobacco products other than IQOS in the past 30 days
* Chronic cardiovascular conditions, seizures, or abnormal blood pressure
* Current psychiatric disorder requiring active treatment, including major depressive disorder
* Regular use of prescription medications that may influence cardiovascular function, respiratory function, or nicotine metabolism (excluding vitamins or birth control)
* Use of cocaine, opioids, benzodiazepines, or methamphetamines in the past month
* Marijuana use on more than 15 days per month
* Current pregnancy or breastfeeding
* Plans to quit nicotine or tobacco products within the next 30 days

Where it's running

• Clinical Aerosol Technology Laboratory (CATLAB), American University of Beirut
  Beirut, Beirut, Lebanon Recruiting
• Clinical Aerosol Technology Laboratory (CATLAB), American University of Beirut
  Beirut, Lebanon Recruiting

Study contacts

• Principal investigator: Soha Talih — American University of Beirut Medical Center
• Study coordinator: Soha Talih, PhD
• Email: st38@aub.edu.lb
• Phone: +961-1-350000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.