Condition

Cigarette Smoking clinical trials and research

• 19Clinical trials
• 14NIH research projects
• 3Countries

Newest Cigarette Smoking clinical trials

All recruiting trials (19)

• Choice-based harm-reduction sampling to help people not ready to quit smoking

  This project will test whether letting smokers who aren't ready to quit choose and try a harm-reduction product (an e-cigarette or a nicotine pouch) leads to less cigarette use over six months than giving a nicotine patch plus lozenge.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07199517

• How a very-low-nicotine cigarette standard and product prices affect illegal cigarette buying

  This study will test whether requiring very-low-nicotine cigarettes and changing e-cigarette or illegal cigarette prices changes illegal cigarette buying and use of alternatives among adult smokers and dual users.

  Recruiting Virginia Polytechnic Institute and State University · Roanoke, Virginia · NCT07161050

• How different tobacco tax plans and availability of regular versus low-nicotine cigarettes affect what smokers buy in a virtual marketplace

  This project tests whether four different tobacco tax proposals and the presence or absence of regular (normal-nicotine) cigarettes change purchasing choices among adult daily smokers in a simulated marketplace.

  Recruiting at 2 sites Virginia Polytechnic Institute and State University · Buffalo, New York and 1 other locations · NCT07142668

• Quit-smoking support for fathers of sick children

  This project will try a proactive program of brief advice, free nicotine replacement sampling, and smartphone counselling to help fathers of sick children stop smoking.

  Recruiting The University of Hong Kong · Hong Kong, Pokfulam · NCT07014124

• Varenicline-based approach to help Veterans who smoke see if they can reduce smoking and try to quit

  This study tests whether varenicline, plus motivational support, helps Veterans who aren’t ready to quit reduce smoking and make quit attempts.

  Recruiting at 3 sites Phase 4 VA Office of Research and Development · San Diego, California and 3 other locations · NCT06966362

• Evaluating nicotine pouches for quitting smoking

  This study is testing if tobacco-free nicotine pouches can help smokers switch from cigarettes by trying out different nicotine levels over 28 days.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06678789

• Impact of THC on Cigarette Smoking Behavior

  This study is testing how different amounts of THC affect smoking habits and cravings in healthy adults who smoke cigarettes and use cannabis.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT06609083

• Mobile program to help young adults stop or cut down e-cigarette use

  This project will try a smartphone program to help 18-26-year-olds who use e-cigarettes or both e-cigarettes and regular cigarettes quit or cut down.

  Recruiting University of Chicago · Chicago, Illinois · NCT06395415

• Evaluating e-cigarettes versus traditional quit methods for smoking cessation

  This study is testing whether e-cigarettes can help smokers quit better than traditional methods like nicotine patches or medication.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06373679

• Evaluating e-cigarettes and nicotine pouches for smokers

  This study is testing whether e-cigarettes or nicotine pouches can help long-term smokers quit regular cigarettes and reduce their smoking habits over six weeks.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06372899

• Evaluating how flavor affects smokers switching to e-cigarettes

  This study tests whether different e-cigarette flavors can help smokers switch from regular cigarettes to e-cigarettes more easily.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06264154

• Impact of switching from menthol to non-menthol cigarettes on inflammation and smoking behavior

  This study is testing how switching from menthol to non-menthol cigarettes affects inflammation and smoking habits in people who usually smoke menthols.

  Recruiting Rosalind Franklin University of Medicine and Science · North Chicago, Illinois · NCT06232447

• Using semaglutide to help manage weight after quitting smoking

  This study is testing if a weight loss medication called semaglutide can help people who have recently quit smoking manage their weight better.

  Recruiting at 2 sites Phase 2 The University of Texas Health Science Center, Houston · Austin, Texas and 1 other locations · NCT06173778

• Adaptive treatment for smokers struggling to quit

  This study is testing different ways to help smokers in Alabama and South Carolina quit by giving them free medications and adjusting their treatment based on how they're doing over 12 weeks.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06118502

• Using e-cigarettes to help smokers with serious mental illness reduce smoking

  This study is testing if e-cigarettes can help people with serious mental illness cut down on smoking compared to traditional nicotine replacement therapies.

  Recruiting NYU Langone Health · New York, New York · NCT05815199

• Using e-cigarettes to help smokers with opioid use disorder reduce smoking

  This study is testing if using e-cigarettes can help people with opioid use disorder who smoke to cut down on their cigarette use more effectively than just getting counseling and nicotine replacement therapy.

  Recruiting Phase 2 NYU Langone Health · New York, New York and 1 other locations · NCT05722561

• Investigating the effects of propranolol and nicotine patches on smoking cues

  This study is testing whether taking propranolol and using nicotine patches can help daily smokers resist the urge to smoke when they see things that remind them of smoking.

  Recruiting Phase 4 University of Oklahoma · Tulsa, Oklahoma · NCT05587361

• Mobile health technology to help people quit smoking in Laos

  This study is testing a mobile app designed to help people in Laos quit smoking by providing personalized support and resources.

  Recruiting at 2 sites Phase 2 University of Oklahoma · Champasak and 1 other locations · NCT05233228

• Using brain stimulation to help people quit smoking

  This study is testing if a special brain treatment can help people quit smoking by focusing on specific areas of the brain that are linked to tobacco addiction.

  Recruiting at 2 sites Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT04903028

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding why lung cancer risk from smoking differs among populations

  This grant looks at why people from different groups have different lung cancer risks from cigarette smoking and what genetic and biochemistry clues explain those differences.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11411158

• Multi-omic insights into alcohol use disorder with and without smoking

  A scientist team will study how DNA methylation and RNA patterns in brain tissue differ in people with alcohol use disorder, comparing those who smoke to those who don’t, to understand biology and potential drug targets.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11402206

• Harm-reduction sampling to help people not ready to quit smoking

  A practical approach tests whether giving people who aren’t ready to quit access to harm-reduction smoking aids can help them move toward quitting.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11397774

• Effects of e-cigarettes, nicotine pouches, menthol and nicotine on adults’ smoking and addiction

  This grant tests how different non-cigarette products and their ingredients affect smoking behavior in adults who currently smoke.

  NIH research Yale University · New Haven, United States · NIH-11394369

• Social and psychological factors behind Black adults’ smoking gaps

  This project looks at why Black adults who smoke have more trouble quitting and what social and psychological factors influence quitting, with the goal of creating tailored cessation support.

  NIH research City College of New York · New York, United States · NIH-11285697

• PTSD therapy combined with intensive smoking-cessation support for veterans who smoke

  This project combines proven PTSD therapy with extra smoking-cessation counseling, nicotine support, and rewards-based coaching to help Veterans with PTSD quit cigarettes.

  NIH research Durham VA Medical Center · Durham, United States · NIH-11188950

• Why smoking raises lung cancer risk differently across racial and ethnic groups

  This project looks for genetic, biochemical, and epigenetic reasons why cigarette smoking leads to different lung cancer risks in people from several racial and ethnic groups.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11180249

• Helping new mothers avoid smoking after childbirth

  This project looks at whether adjusting hormone levels can help new mothers stay smoke-free after their baby is born, protecting both mom and child.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11116923

• Investigating how PUMA contributes to lung damage from smoking

  This study is looking at how a protein called PUMA affects lung damage and inflammation in people with COPD caused by cigarette smoke, with the goal of finding new ways to help prevent or treat the disease.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10930186

• Understanding gene networks related to cigarette smoking and opioid addiction.

  This study is looking at how our genes might influence addiction to smoking and opioids, using advanced technology to analyze genetic information from both living people and brain samples, with the hope of finding better ways to treat these addictions.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-10873140

• Understanding how emotional distress affects cigarette smoking behavior

  This study is looking at how feelings like anxiety and depression can affect smoking habits in adults, especially how struggling to handle tough emotions might make it harder to quit smoking, so we can find better ways to help those who are trying to stop.

  NIH research Rutgers, the State Univ of N.j. · Piscataway, United States · NIH-10864701

• Using hormone therapy to help new mothers avoid smoking relapse

  This study is looking at how giving new moms a hormone called progesterone might help them avoid smoking again after having a baby, making it easier for them to stay smoke-free and protect their little ones from secondhand smoke.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10861712

• Investigating how menthol cigarette smoking affects blood metabolites and lung cancer risk

  This study is looking at how smoking menthol cigarettes might affect the risk of lung cancer, especially in African Americans, by analyzing blood samples to find out what changes in the body could be linked to this type of smoking and cancer.

  NIH research University of Florida · Gainesville, United States · NIH-10833699

• How cigarette smoke affects cell responses through tRNA modifications

  This study is looking at how cigarette smoke affects tiny molecules in our cells that help control how genes work, which could help us understand how smoking impacts our health.

  NIH research State University of New York at Albany · Albany, United States · NIH-10823293

Related topics

Quick answers

How many Cigarette Smoking clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (17 trials), Laos (1 trial), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 4: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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