Understanding habits and decision-making in alcohol use disorder
Official title: SFB TRR 265: Losing and Regaining Control Over Drug Intake Project B03: Role of Pavlovian Mechanisms for Control Over Substance Use Project B09: Maladaptive Context Inference As Key Mechanism Underlying Impaired Control
Run by Technische Universität Dresden · NCT06701500 · Data updated 2026-11-12
This study is trying to understand how habits and decision-making affect people with Alcohol Use Disorder compared to those without it.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 180 (estimated) |
| Sponsor | Technische Universität Dresden Academic / other |
| Locations | 1 site (Dresden) |
| Status | Recruiting |
| Started | March 2, 2024 |
| Main results expected | March 31, 2025 |
| Study ends | June 30, 2027 |
| Registry record updated | November 22, 2024 |
| Trial ID | NCT06701500 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18-65 who meet the criteria for moderate to severe alcohol use disorder.
✕Probably not a fit
Patients with severe mental health conditions such as bipolar disorder or schizophrenia, or those currently experiencing severe depression or acute drug intoxication, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the role of habitual behaviors and decision-making processes in individuals with Alcohol Use Disorder (AUD). Using a novel Action-Sequence-Task (AST) and a Pavlovian-to-Instrumental Transfer (PIT) paradigm, the study will compare the performance of 90 AUD patients with 90 matched controls. Participants will engage in tasks designed to assess the interference between habitual and goal-directed control, as well as the nature of the PIT process. The findings could provide insights into the cognitive mechanisms underlying addiction and inform future treatment strategies.
Why it matters
Potential benefit: If successful, this study could enhance understanding of addiction mechanisms, leading to improved interventions for patients with alcohol use disorder.
How similar studies have gone: While the specific methodologies may be novel, previous studies have indicated that understanding the interplay between habitual and goal-directed processes can yield valuable insights into substance use disorders.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-65 years of age * AUD subjects only: meet 4 or more criteria for DSM-5 alcohol use disorder * Sufficient motor skills and visual acuity to use PC * Ability to consent to the study and complete the questionnaires * Sufficient German skills Exclusion Criteria: * Lifetime diagnosis of DSM-5 bipolar disorder, schizophrenia or schizophrenia spectrum disorder * Current diagnosis of severe major depression according to DSM-5, or presence of suicidal intention * Pregnancy * Severe withdrawal symptoms * Acute drug intoxication at the appointments
Where it's running
-
Department of Psychiatry and Psychotherapy, Technische Universität Dresden
Dresden, Germany Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.